Keep going back and forth on which to add….

I'm also not looking to stop Tirz. The appetite benefits have been strong, so switching entirely to Reta isn't appealing.

From what I've seen, inserting Cagri between the Tirz injections makes a noticeable difference.

I chose Cagri for the same reason, wanting to remain on Tirz and possibly test Reta later during maintenance. Adding it a month and a half ago led to another 12 lbs lost. Current schedule is 6 mg Tirz on Tuesdays and 700 mcg Cagri on Saturdays.

Not a doctor, so treat this like advice from any random person online. Instead of raising my Tirz dose I added Reta a few days later. Tirz on Friday mornings, Reta Monday evenings. Started at 0.5 mg for a couple weeks with no issues, moved to 1 mg, then recently to 1.5 mg. Reta isn't the strongest appetite suppressor on its own, but together they work well. No weight loss yet because I had already plateaued, which is why I added it. On 7.5 mg Tirz, the return of food noise prompted the cautious Reta start between doses so the effect doesn't fade. Appetite remains but without the mental noise, which is pleasant. I can still enjoy meals unlike with sema.

Is the fluctuating suppression happening before the next shot or something different? If you can increase the Tirz dose, that might buy time to choose what to add. Splitting the dose or moving shots to every five or six days would also raise the weekly amount. I haven't tried Reta, Cagri, or survo because I'm cautious, so no personal experiences there. Shortening to six days helped until I decide.

I've been on 2.5 mg Tirz for four weeks and also wanted to try the Tirz plus Reta stack. On Tirz alone the suppression was similar to what you described, present but inconsistent. After adding 1 mg Reta three days after the fourth Tirz shot, suppression became very strong the next day. Physical hunger is still there but mental food noise is gone. Eating changes the most: I have to go slow, get full after a few bites, and finish the rest just for nutrition. Might drop Reta to 0.5 mg next week depending on how things go. Also noticing better energy, clearer thinking, and less fog, so it seems worth it.

I'm desperate for your help because it looks like you're the last chance I've got.

A lot of reports mention combining Reta with Tirz, and one video points out dosage as a key factor often missed. Using two peptides at full strength on the same receptors probably isn't ideal, but keeping one at a lower supplemental dose while the other stays higher seems more reasonable. The video covers whether stacking Tirzepatide and Retatrutide is safe. Always keep learning.