ForumDosing & Titration

Titration suggestions?

5 replies5 peopleOct 22, 2025☆ Follow
Summary

What titration schedules work for this medication when side effects are minimal?

Users describe personal schedules starting at 2 mg and moving to 4 mg then 8 mg, with some staying at 8 mg long-term. Several followed study-like steps but shortened intervals when no sides appeared, and one reached 6 mg after shorter holds at lower doses while reporting steady weight loss. Most see 8 mg as the practical maintenance point because the added benefit at 12 mg does not justify extra sides for them.

What this discussion establishesWhere people disagree

How quickly to move through the lower doses when sides are absent

Nothing here is advice.

5 replies · 5 people
KeenLantern39archiveopening postOct 22, 2025

Studies I've looked at used steps of 2 mg for four weeks, then 4 mg for four, then 8 mg for four. Some participants began at 4 mg while others started at 8 mg, and the main difference was how many sides showed up. My first shot was 2 mg and I barely noticed anything. With no sides so far I'm considering moving faster: 2 mg, then three rounds at 4 mg, then two at 8 mg and staying there. Any ideas on going quicker than the usual 2x4, 4x4, 8x8 pattern?

NorthAnchor41archiveOct 22, 2025
↳ replying to @KeenLantern39 (opening post)

Increase only when it suits how you're feeling. If the amount you're on now is getting results, there's no need to go higher right away.

GreenWillow55archiveOct 22, 2025
↳ replying to @KeenLantern39 (opening post)

I basically followed the same path, beginning at 2 mg, spending a few weeks at 4 mg, then stepping up to 8 mg. I chose to remain at 8 mg because the studies showed a smaller gain moving from 8 mg to 12 mg compared with the gain from 4 mg to 8 mg.

IronWillow10archiveOct 22, 2025

I followed the same approach.

KeenLantern39archiveOct 23, 2025
↳ replying to @GreenWillow55

From the published studies I've seen, the extra sides at 12 mg don't seem worth the small extra weight-loss difference. The glucagon effect appears to become active once you reach 8 mg.

KeenPebble77archiveOct 29, 2025

I used a different schedule. I stayed at 2 mg for two weeks, moved to 4 mg for three weeks, and started 6 mg this week. So far I've lost about 20 lb, I can still eat but don't feel any urge to do so.

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