User experiences dosing timing and effects of mitochondrial peptides SS-31 NAD+ with GLP-1 agonists

The person mentioned knows the topic, yet I always pick up a pushy sales feeling from the presentation. That does not mean the information is worthless, and I have picked up a few useful points from listening before.

Once my ss-31 and nad+ arrive I plan to test the protocol on myself first before using it for my mom.

I began the same protocol last week. Most of me suspects it is probably not going to do much and until recently all I knew about mitochondria was the basic description, but the idea looked interesting and I was bored. I am still only on the nad+ portion. I tried 25 mg first, then 50 mg, checking for side effects, and had none. Last night I went to the full 100 mg. I noticed a clear difference that time and felt wide awake for the first time in weeks, then took a nice three-mile walk. It is probably just placebo, so from now on I will follow the directions exactly.

I am planning a modified version of the cycle using the vials I already have on hand: ss-31 at 10 mg, mots-c at 10 mg, and nad+ at 500 mg. I am short on ss-31 and may need another kit. I will begin early next year. At 45 I could use the mitochondrial support and an energy lift, especially since reta and the calorie deficit are affecting me even though trt helps overall. I will follow the thread for reports from others who have tried something similar. The schedule I have in mind is ss-31 3.57 mg daily, mots-c 3.33 mg or 5 mg on Monday Wednesday Friday, and a gradual nad+ ramp over several weeks up to 200 mg twice weekly.

The glucagon action from reta is said to stimulate new mitochondria formation and improve performance, though I do not recall the exact source.

The reference I found explains that glucagon activates pathways such as PGC-1α which regulates creation of new mitochondria, leading to higher oxidative capacity, better fat burning and thermogenesis.

I tried some ss-31 and mots-c and noticed a slight energy lift from the mots-c. I take a nad precursor capsule every day but cannot tell any difference. The practical way to check would be finding a lab that offers a mitochondria function test and comparing results before and after a course.

I am the same age. I am on week four of the protocol that was posted and I ran a cycle earlier this year. Mitochondria decline with age so a cycle is likely to help, though noticeable effects are not guaranteed. Ss-31 gives me a clear increase in alertness. Nad+ produces only an initial rush when dosing. I was not training during the mots-c portion so I could not check for better endurance that others have reported. Not everyone feels a physical response from each item, yet benefit may still occur. Older users tend to notice more. This time I will time the mots-c doses with my workouts to test for performance gains.

This thread is turning out well. I was trying to stay diplomatic earlier and I like the direction it is taking. Another presenter in the same space also comes across poorly to me.

Does anyone have experience or confidence in nad+ patches?

What leads you to that conclusion?

I began by following the basic guide during my micro-dosing phase and also watched several physicians discuss the approach, which has worked well for me at low doses. Some statements from the two main voices have raised concerns though. One explains topics clearly in videos, which is helpful, while the other seems less grounded. Both have made comments that come across as dismissive toward people who are not in top physical shape.

One of the two is mainly a marketer with a medical degree rather than a researcher publishing data, so the material leans heavily on hype. The other is a real physician but the peptide assertions often outpace available evidence. Credentials alone do not convert speculation into fact. The choice comes down to whether you prefer curiosity-driven claims or sticking with what is actually proven. I prefer to follow the science where possible and always ask who is making the claim and how they know it. Plenty of people profit from hope and bias, and chasing optimization when no clear problem exists often leads to someone selling you a solution. Uncertainty plus fear of missing out is a risky starting point.

It is difficult to trust someone whose main goal appears to be selling products. A family member has known one of the promoters for decades and praises the business success yet criticizes peptide use and never acknowledges visible changes after major weight loss.

A physician assistant I know who works in surgery has repeatedly seen specialists assume expertise outside their field and make unsupported claims during procedures. Expertise in one area does not automatically extend to others. The same principle applies to anyone whose training is unrelated to the topic at hand.

Sorry for taking the thread off topic.

Mots-c makes me feel good, whether it is actually repairing mitochondria or something else. My mother felt unwell for two weeks on it before improving, which some descriptions link to a metabolic adjustment period. At 35 I may already be in decent metabolic condition. The main drawback is having to reconstitute fresh vials frequently when protocols call for higher single doses, and larger vial sizes are uncommon.

Are you happy with the quality?

Your progress really motivates me since you've come so much farther along than where I stand now.

NR or NMN is cheap if you know where to find them and are precursors to NAD, no need to inject, just pills. On them currently before my SS-31 arrives, which I plan to run a good month or two then take time off. Don’t feel the need for MOTS-C and will take NR indefinitely.

Curious how running that peptide stack turned out. Does it serve as a workable substitute for growth hormone or does it make more sense to just go with the actual version? I'm planning to stick with minimal therapeutic amounts around two or three units.

Swimmer, people in their sixties might benefit from extra mitochondrial support. Being 69, I found Mots-NAD+ and SS-31 produced visible gains in my energy and exercise results. The problem remains the absence of firm studies on how much to take with these peptides. Personal testing was necessary to determine suitable quantities for myself. Being costly, and with suggestions to use tiny amounts, that method yielded no effects for me. What succeeded was SS-31 at ten milligrams every day over twenty days. After, I did Mots-C daily at ten milligrams plus NAD+ at one hundred milligrams three times each week. Additionally 5-Amino 1MQ went into the mix at fifty milligrams three times daily. Doses were raised step by step to the point where changes showed up, leading to these amounts. The combination of Mots-C and NAD+ continued for thirty days and I have done the whole thing two more times. Individuals vary so each must customize their own process to achieve wanted effects. Report back on experiences once a cycle finishes to inform others. Best wishes.

My supplies for the cell energy study are still on the way. Earlier I finished a month-long run with one specific peptide and everything felt fantastic. Two milligrams every other day left me with plenty of stamina and drive. I have no idea how poor my cell condition might be, yet at forty-one after years of self-neglect I figure it is fairly poor. Getting older feels tough once you spent so long acting like you wanted an early end. I am eager to test this method because I want to stabilize my basic body chemistry before looking into other topics such as additional workout-related substances.

Nothing stood out to me while increasing the first compound. I began with a smaller amount and raised it during week two instead of holding off. On a whim I started the next one ahead of schedule. I plan to finish the entire six weeks of it without beginning the last one sooner. Tiredness has dropped in a clear way, yet I won't judge anything for at least another couple of weeks since I pick up on suggestion effects so easily.

My order of that supplement finally arrived. The containers came in a bigger size and with a brownish tint. The other compound I requested weeks back hasn't shown up yet. Since I placed the request quite some time ago, arrival should happen shortly. Waiting any longer feels impossible. Still feeling uneasy trying this fresh peptide. Should something go wrong, my flatmate would discover the situation, preventing my pets from needing to consume parts of my dead body for food. Appreciate the person who shared that idea.

Last Monday evening marked my initial try with a tiny amount of NAD+. The spot where I injected didn't cause any real issues, though I struggled a little to drift off at night. Is it common for folks to do these in the morning instead? I've got some SS31 coming in soon too, and I'm curious about the ideal hour for taking peptides like these that target mitochondria.

For several years I've used Epitalon because it lengthens how often normal cells can copy themselves. Humanin has helped me cut back free radical damage, support energy production inside cells, and handle sugar levels better during that time. This targets aging right at the cellular scale. I started Sema and Reta since they combine with Humanin to counter brain decline and metabolic shifts through separate routes, with one working inside cell power plants and the other via gut hormone signals across the body. Those two don't touch chromosome ends directly, yet they ease body strain from weak insulin response and persistent swelling, which helps keep the chromosome ends working longer. I once relied on SS31 and Mots-c to ease swelling too, but with all the other overlapping compounds in my routine now I don't depend on those two nearly as much.

A delivery of NAD+ should reach me shortly. This marks my initial attempt with the substance and I feel eager to begin the injections. I intend to open at a bigger amount like fifty or one hundred milligrams three times each week.

About half a year back I tried one compound followed by another and noticed a modest lift in stamina the first was aimed at restoring cellular power plants these days I take a few different ones three or four times weekly and moving through the hours feels straightforward lately entering that stage my stamina had dropped sharply and nightly rest stayed under six hours without my choosing I used to crave a daytime break yet job tasks always blocked it with the present routine I no longer sense constant strain I get weary but not wiped out I keep adjusting rest little by little incidentally during one earlier cycle my rest turned out excellent when taken before lying down also using another medication