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5 months on tirz compound with success. Lowered tirz and adding reta. Im joining the reta craze. Big belly no more....maybe. fingers crossed.

9 replies6 peopleMay 26, 2026☆ Follow
Summary

experiences switching from tirzepatide to retatrutide or stacking both for weight loss while managing joint pain and side effects

Users report steady weight loss on tirz then adding or switching to reta, with mixed results on joint pain relief and new side effects like night sweats or skin sensitivity. Some regain knee pain after dropping tirz and plan to reintroduce it, while others note reta helps with visceral fat but may raise resting heart rate. Stacking or alternating doses is common as people experiment with what works for inflammation versus scale movement.

What this discussion establishesWhere people disagree

whether reta alone can maintain joint pain relief or if tirz must be kept for that benefit

Still open

optimal long-term dosing or stacking schedule for sustained results without returning inflammation

Nothing here is advice.

9 replies · 6 people
PatientMeadow16archiveopening postMay 26

Maybe it's foolish, but I'm trying anyway. I dropped 35 pounds in about four and a half months using compounded tirzepatide, reaching 8.5 mg before it didn't agree with me. Dropped back to 6.5 mg and started retatrutide at 1 mg weekly for three weeks alongside the tirz. Nothing much happened. Bumped reta to 1.5 mg while keeping tirz at 6 mg, and put on 3 pounds. Been using reta for six weeks total now. Noticing night sweats, waking early, and feeling warmer overall, which seems normal I suppose. The scale started moving the right way after four weeks. Planning to phase out tirz over the next couple months to switch fully to reta. Worried my knee and wrist pain might come back. Hoping to see the visceral fat reduction from reta since I have a big gut, but the knee relief has been the best part. I'd rather deal with extra weight than bad knees. Sticking with reta heavily for another four weeks and will check back then.

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GreyPebble98archiveMay 26

I've been on reta for three months and lost around 25 pounds. Food noise returned and weight has held steady for three weeks. Skin sensitivity is constant and bothersome. I ordered tirz and plan to try it, though I haven't decided if I'll combine them or switch completely. Need a sensible starting dose.

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PatientMeadow16archiveMay 26
↳ replying to @GreyPebble98

I'm still figuring this out and trying to choose wisely for myself. Everyone's learning as they go. If I had to share anything so far, tirz gave the biggest improvement with my knee pain, and the weight came off too.

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PatientBeacon15archiveMay 26
↳ replying to @GreyPebble98

If you find anything that helps the skin sensitivity let me know, because that's what made me stop reta. Suggestions I've seen include antihistamines, electrolytes with plenty of water, guaifenesin, or zinc. Tirz worked great for me and I lost a lot on it by itself. Still want to try reta again later for maintenance and other benefits.

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BrightSparrow36archiveMay 26

I added reta after about two months on tirz and I'm now finishing month four of GLP use with 39.9 pounds down on 7.5 mg tirz plus 1 mg reta. Progress has been good the whole time. Resting heart rate has even started dropping since the recent reta increase.

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PatientMeadow16archiveJun 27
↳ replying to @PatientMeadow16 (opening post)

Update after three weeks with no tirz, just reta. I've done ten injections and raised the dose gradually to what feels comfortable. Last one went from 3 mg to 4 mg. Wish I had begun at 2 mg since I'm a bigger guy, though everyone varies. Resting heart rate sits about seven beats higher than usual. Sleep feels odd but the watch data looks fine except total hours, around five to five and a half nightly, yet I wake up rested. Knees are starting to bother me again after months without pain, though not severely. Wrist pain remains gone. If the knee issue keeps worsening I'll probably add a bit of tirz back. Some other supplies are on the way but not here yet.

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SteadySparrow75archiveJun 27
↳ replying to @PatientMeadow16

Nice work. You probably already know about BPC-157 and TB500. They took a while to build up for me but are helping my chronic back pain quite a bit now. Good job and good luck going forward.

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PatientMeadow16archiveJun 27
↳ replying to @SteadySparrow75

Thanks. I've read so much my eyes hurt. I know about that combo but haven't tried it. Still pretty new to all this but picking it up fast. Would take more risks if I were twenty years younger. Keeping things slow for now. Weight is also coming off slowly, which is fine with me.

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PatientMeadow16archiveJul 7

I'm not messing around. My knees hurt and wrist pain returned. Forget the scale, even though it's moving the right direction. Inflammation is back and hitting hard. Knees are the main problem. After reading the whole thread history, I'm adding 4 mg tirz today. Will share more once I'm in a better mood. Reta isn't enough for me.

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IronKettle95archiveJul 8

I use 7.5 mg tirz and 3 mg reta on Friday and Tuesday. As I near goal weight I don't plan to drop either one since they offer different advantages. Twice-weekly shots seem to smooth out the tirz half-life. What made you decide to stop tirz entirely? Congrats on the progress.

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