Users report sudden energy crashes resembling a workout bonk several hours after increasing retatrutide, often fixed quickly by carbs. Most trace it to blood-sugar drops or electrolyte and fluid imbalance rather than the dose jump itself. Similar episodes occurred on tirzepatide too when meals or drinks were skipped. People with low blood pressure or suspected hypoglycemia seem more affected and some pause the drug during intense training.
What this discussion establishesSome see the 1 mg increase as the trigger while others say the same episodes happen even on stable low doses and are just from forgetting to eat or drink.
Still openWhether certain people with low blood pressure or hypoglycemia are inherently more prone and should avoid reta during heavy training.
Nothing here is advice.
After raising my dose from 2 to 3 mg I hit a wall about six hours later that felt exactly like a long bike ride with no fuel left. Shakiness, dizziness, and nausea hit hard until I ate a big slice of pie plus some ice cream and felt normal again in thirty minutes. Has anyone else run into this after a dose increase, or did I just go up too fast?
Might be electrolytes if carbs fixed it that quickly. How much water had you taken in?
I opened the thread expecting something else entirely after the shot. Never had that exact crash right after dosing, though I have bonked at other times. The allodynia made it feel a bit different. Dehydration or low blood sugar seems likely, and those have hit me at random points during the week.
I agree it is probably blood sugar or not drinking enough. I have to force myself to stay on a drinking schedule because reta makes me forget, and then the dizziness shows up.
A glucose meter is useful to keep around. Protein drinks supply sodium, potassium, magnesium, and calcium, though they are not as good for hydration as dedicated electrolyte drinks or coconut water. I drink one or the other first thing in the morning. I never had dehydration problems until starting these meds. If the nausea returns, some people ask their doctor for something to settle the stomach.
An online search suggests low blood sugar is more likely than dehydration as the main cause.
I think the blood-sugar idea fits what I felt. It really did seem like my levels crashed. Probably went up too fast and also injected the two weekly shots too close together. I have also noticed I need to keep carbs in my diet on this medication because low-carb eating leaves me feeling off.
I actually paused reta while training for a half marathon because I kept hitting the wall on long runs even at a very low dose. Once the race was over I started again. I already deal with low blood pressure and sometimes feel faint when standing up fast, and I wonder if I also run low on blood sugar. A monitor might be worth getting. Some people with those tendencies could be more likely to bonk on this drug.
Interesting. Sounds like you may need to stop it again if you do any serious training.
Looks like a blood-sugar or hydration problem. Make sure you add electrolytes to your water and eat some fruit for natural sugars.
I have not heard bonk used for those symptoms before. I always thought it meant hitting your head. Early on tirz I had similar short episodes that almost always came from skipping food or water or eating something that did not sit well. Once I got better about routines and added electrolytes and protein shakes on days I had not eaten much, the episodes became rare. A one-milligram jump probably would not cause such a strong reaction beyond normal side effects.
Because reta boosts the incretin response, eating some carbs ahead of the dose to lift blood sugar might prevent the crash.
I agree that keeping carbs in the diet is necessary for reta to work well. After switching from tirz I went back to normal carb intake and have held my weight steady since.
If you do not have diabetes and are not on other blood-sugar-lowering drugs, these medications do not cause true hypoglycemia on their own. The symptoms are common during weight loss and usually come from fluid and electrolyte shifts plus lower blood volume leading to dizziness when standing. Most electrolytes come from food, so eating less can drop levels of potassium and sodium. The meds also cut fluid intake. The practical fix is to sit or lie down when dizzy and then eat something while drinking water.
I would be worried about blood sugar. Any recent alcohol?
My brother was just told he has type 2 diabetes. We checked our levels with his meter after a few drinks and his was high while mine was low. I am on 8 mg split into two shots but have not noticed low-sugar symptoms myself, though it is something to watch.
If you have tried it, this topic is still open. Sign in to reply — it takes a minute.