Sema to Reta dose help please

Because reta works on three receptors instead of one like sema, begin at the 2 mg dose used in the studies. Appetite control will probably feel weaker at first since you're back at the lowest amount. After four weeks go up to 4 mg if you need more, then to 6 mg after another four weeks, and continue that pattern for 9 mg and 12 mg.

I agree with starting at 2 mg per week. I would split it into 1 mg twice a week, especially with a new kit. I didn't want to stay at the same dose for a full month unless I was near maintenance. If weight starts coming back after the switch, adding some leftover sema is another option.

I would also start at 2 mg of reta, but if you expect to raise the dose faster than every four weeks, split it as 1 mg twice a week. Smaller doses more often tend to cause fewer problems than larger ones less often. A quicker increase is probably safe given you had no issues on 2.4 mg sema. Reta generally has somewhat lower side-effect rates than sema, especially stomach-related ones, though it can raise heart rate and sometimes cause anxiety or insomnia. If you plan to adjust doses or skip the standard four-week steps, a GLP plotter helps show how the drug levels change over time.

I wouldn't stop the sema all at once. Lower the sema dose while you raise the reta dose.

Maybe you're holding steady on weight yet still feel that pull to experiment? Or hoping to shed a few more? Getting great rest these days? When starting a combo after switching those meds, the part that stands out for me is deciding the initial dose of the newer one. I'd likely stay at or below a milligram early on, whether split across days or not, before increasing down the line. Unsure how far to drop the previous med though.

If food noise was an issue before sema, it could return with reta alone. You might want to keep a little sema along with the reta if food noise matters to you.