Making Switch from Tirz to Reta

My doses were lower so maybe not as useful, but I skipped any weaning schedule. One week I used Tirz and the next week Reta. Found what looked like an equipotent dose and switched to it. Kept the same Sunday morning schedule even though Reta's half-life is a bit longer. That was back in August and it worked fine; no going back since.

I don't think there's a precise way to match up the amounts of these two substances based on their effects. From what I've seen with weight reduction, the higher dose of the first one lines up roughly with a medium amount of the second. However, the second one brings along some extra reactions tied to overactive nervous system stuff, such as faster pulse, trouble sleeping, and weird skin sensations. The first one skips the glucagon part entirely while the second one hits it, and that's behind most of those differences. Also the first one hits the GIP part a little harder, which helps offset some stomach upset from the GLP-1 action, meaning the second one might cause more of that too. Jumping straight to that medium amount seems like it could cause trouble for several days at least, and I've read about folks running into issues even with lower starting points. It might be better to begin with a small amount of the second one and monitor how it goes, though stepping up the amount more quickly than usual doesn't seem too dangerous if you watch for any growing discomfort and adjust accordingly.