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Exercise triggered gallbladder pain stones management options

76 replies27 peopleMay 8, 2026☆ Follow
Summary

how to handle confirmed or suspected gallstones causing pain during activity while deciding on surgery or alternatives

Participants report exercise-induced attacks often linked to rapid weight loss or skipped meals, with milder cases managed via bile-flow supplements while awaiting insurance approval for imaging or procedures. Many stress ultrasound to exclude pancreatitis and share self-experiments adjusting fat timing and refeeds. Accounts include pain on walking or running, cost barriers, and occasional discovery of unrelated issues during attacks.

What this discussion establishesWhere people disagree

whether to pursue surgical removal, preservation procedures, or continue monitoring with supplements

Still open

optimal testing schedule and whether to slow exercise intensity

Nothing here is advice.

76 replies · 27 people · page 1 of 2
QuietSignal61archiveopening postMay 8

Dropped roughly eighteen pounds across five weeks on Reta and now running brings on gallbladder discomfort. Quick shedding is known to trigger stones. Searched the board for gallbladder and it looks like most people who slimmed down on a GLP ended up getting the organ removed. Should I just hold off until the ache forces an ER trip and hope the operation comes at no cost? Update with numbers: started at 236 now 216, week seven on reta, began at 2.33 mg weekly and went up to 4.66 mg by week five. Male, six foot, twenty-seven. Pain hit during a run yesterday. Might tie to a calcium pill I probably didn't need. Last night in bed I felt what seemed like stones moving right under the ribs at the two o'clock spot. This morning the run got cut short from the same ache. Breakfast was only a protein shake with skim milk, zero fat, yet the spot hurt again just like other mornings after a shake plus some heavy brownies I baked.

LevelThistle44archiveMay 8

No problems here and I had lipase plus amylase checked last month just in case. Bloodwork might give you some peace of mind too. Easing the calorie gap a bit could ease what you're feeling.

IronAlder42archiveMay 8

My daughter has been dealing with gallbladder trouble after she dropped weight fast. I haven't run into it myself because I took two years to lose at about a pound a week. Big weight drops of any kind raise the odds of gallbladder trouble.

CopperAlder51archiveMay 8
↳ replying to @QuietSignal61 (opening post)

That pace is pretty fast. Two pounds a week is the usual safe limit. Maybe drop the dose or eat a little more? I've been averaging 2.2 pounds weekly over nine months with no trouble.

SlowSignal40archiveMay 8

Jeez that thing left me shaking from pure fright.

QuietSignal61archiveMay 8
↳ replying to @CopperAlder51

Hoping it's just that calcium pill from the other day. Trouble shows up mostly on big deficit days. Happened on a walk yesterday and pops up now and then with mostly liquid meals, but it hit again today so I switched to a rich meal loaded with healthy fats. Skipping the calcium from now on and will check back if anything gallbladder-related shows up. On your question, I'll watch the deficit more but I'm not lowering the dose. Not doing this for health reasons, just want the weight off. Aiming for three pounds a week. For the record, six foot, started at 236, week seven on reta, 2.33 mg weekly at first then up to 4.66 mg after week four.

QuietSignal61archiveMay 8
↳ replying to @IronAlder42

Can't be totally sure but I think I've had that same gallbladder ache off and on for years, just way less often than lately. Might be mixing it up with precordial catch or liver pain, but the feeling isn't new.

GreenMeadow54archiveMay 8

Never heard of this so I looked it up quick. A JAMA paper on GLP-1 receptor agonists and gallbladder or biliary disease risk from a meta-analysis of randomized trials. First part of the discussion says the review of seventy-six trials found GLP-1 RAs linked to higher odds of gallbladder or biliary problems including stones, inflammation, and other biliary issues compared with placebo or controls. Risk went up in both diabetes and weight-loss trials and was higher in the weight-loss ones. Bigger doses and longer use also raised risk though not always reaching statistical significance. Sounds rough, but the absolute extra risk was about twenty-seven events per ten thousand patients per

CopperAlder51archiveMay 8
↳ replying to @QuietSignal61

Three pounds a week is a lot over time. Anything past about two pounds steadily seems to invite gallbladder trouble. Biggest drop came early for me then it leveled out.

IronAlder42archiveMay 8
↳ replying to @QuietSignal61

Sorry to hear that, and it can be tough to pin down with the history you described. My daughter has been dodging surgery, using malic acid and staying on top of hydration since she's in nursing school and they'd hold her back if she had the operation. She also started a food journal to link pain with what she ate. The ache didn't really change after stopping the shots so she restarted. She thinks the pain got worse off the meds because the food noise returned and she ate more of the wrong stuff.

QuietSignal61archiveMay 8
↳ replying to @IronAlder42

Solid info. Might add magnesium malate. Thanks for the sympathy but it's not needed. My body is a temple, just one of those Thai ones where monkeys leave messes everywhere. This is probably the healthiest I've been since seventeen, and I'm twenty-seven now.

IronAlder42archiveMay 8
↳ replying to @GreenMeadow54

My kiddo says it felt worse without the meds.

LevelThistle44archiveMay 8
↳ replying to @CopperAlder51

Starting at 336 probably helps. I'm on week twenty-one dropping 2.7 pounds a week from 282.

ClearWillow59archiveMay 8
↳ replying to @QuietSignal61

We all want fast results but dropping too quick can cause real harm. My sister had hers removed. I'm fine after fifty-two weeks and fifty-two pounds off. Look after yourself, you still need those organs.

IronAlder42archiveMay 8
↳ replying to @QuietSignal61

From that reply I can tell you'll be okay. Reminded me of something. About six months back I apologized to my body for not loving it as it was, for not appreciating what it had been through, all the stuff I'd put it through trying to measure up. Another upside of the food noise quieting is I'm actually here in the moment more than before. Like to think I'm the personality she should have had years ago.

QuietSignal61archiveMay 8
↳ replying to @LevelThistle44

Holy shit LOL, typo. Started at 236. Highest was probably 260 and hovered around 240 for a couple years. Nice work on the loss, must feel good to be where you are. Already feel better myself but I'll be happier looks-wise once I'm under 200.

QuietSignal61archiveMay 8
↳ replying to @IronAlder42

I know my options are limited to what's feasible at any point. It wasn't possible before, but now it is. I got the most out of the situation back then, and I'm going to do the same again, only with better results this time.

LevelThistle44archiveMay 8
↳ replying to @QuietSignal61

Progress is good but still three or four months from target. Not very emotional about it, kind of surprised it's going this smoothly. Three pounds at 240 is 1.25 percent, more aggressive than the one percent plan I set for myself give or take a tenth.

KeenCinder23archiveMay 8
↳ replying to @QuietSignal61 (opening post)

If folks aren't having gallbladder pain they aren't posting about it so your search only shows the bad cases. Had mine out years ago just from being heavy. Still get liver pain on Reta unless I stay on top of hydration and electrolytes. Fast loss stresses organs so maybe back the dose down to two pounds a week.

SlowSparrow78archiveMay 8
↳ replying to @QuietSignal61 (opening post)

Had mine removed but that was long before Mounjaro or Reta. Tried Saxenda for a year earlier and didn't lose much. Since losing the gallbladder I've had a rough time and would tell anyone to try hard to keep theirs. Watch fatty foods, even some healthy ones. Four years later still can't handle red meat and only recently tolerate chicken without getting sick for days. Dairy only in tiny amounts. Miss steak badly.

QuietSignal61archiveMay 8
↳ replying to @KeenCinder23

True but what stood out was seeing no posts about ongoing pain, just stories of pain one day then removal. Hoping to be the exception people find in this thread later. Probably nutrition plus the fast drop. Also got pain on days with junk like brownies plus liquid protein while holding a seven-hundred-plus deficit.

LevelThistle44archiveMay 8
↳ replying to @QuietSignal61

If you're dropping 3.6 pounds weekly after the first water weight, the daily deficit is probably closer to seventeen hundred calories than seven hundred.

QuietSignal61archiveMay 9
↳ replying to @LevelThistle44

Could be. I tend to overcount what I eat, aim for fifteen hundred and rarely go past two thousand. TDEE should be around three thousand. Heaviest day on reta was about twenty-six hundred but probably closer to twenty-four hundred the way I log.

WarmQuill45archiveMay 9

Can you lay out the exact symptoms and how you decided it's the gallbladder? Plenty of other things cause right upper quadrant pain. Also, people feeling gallstones move isn't something I've come across.

QuietSignal61archiveMay 9
↳ replying to @WarmQuill45

Pain sits about five inches below the right nipple and an inch lower when sitting upright, right at the bottom of the lowest rib. Almost only during effort and mostly on tight deficits or after lopsided meals like brownies and fat-free milk protein shakes. While running a sharp pain builds in that spot and grows with more effort, like precordial catch but shifted. If it lasts too long breathing starts to hurt too. Stopping exercise keeps it from worsening and it fades in fifteen to thirty minutes. Feeling movement there isn't unheard of. Only noticed it those two times, both while still, and it was right where the pain hits, far from gas, stomach, heartburn or palpitations.

WarmQuill45archiveMay 9
↳ replying to @QuietSignal61

Interesting. At minimum get liver function tests and a right upper quadrant ultrasound if you haven't. Both are low impact and useful. One of my friends had something similar for years and ended up diagnosed with slipping rib syndrome that needed surgery.

LevelThistle44archiveMay 9
↳ replying to @QuietSignal61

As long as you're clear-eyed about it, go for it. Hope you keep the gallbladder, zero out of ten on wanting to lose mine.

QuietSignal61archiveMay 9
↳ replying to @WarmQuill45

I'm in America. Walking into a doctor's office means money out of pocket I don't have. Private labs exist but cost a hundred bucks I can use elsewhere. Joking aside, thanks for the info. Slipped rib doesn't match what I'm feeling. The two movement sensations were almost pleasant, no pain, happened while sitting still. Spot feels too high for liver anyway.

KeenKettle50archiveMay 10

Oh yeah, three years back while visiting a friend in Australia on compounded Wegovy I took a sip of chocolate milk and got the worst midsection pain ever. Thought it was bad milk but kept vomiting, broke out in sweat, couldn't eat all day. Virtual urgent care said it might be a GLP-1 gallbladder attack. Glad that's not happening on reta.

RustMarble22archiveMay 10

Your gallbladder can't tell healthy fats from regular ones. Cut overall fat intake and check if that changes anything.

AmberFenwick97archiveMay 10
↳ replying to @QuietSignal61 (opening post)

See a doctor. Don't brush off stones and pain, it can turn serious fast. Almost lost someone close when a stone blocked the bile duct. Get it looked at.

QuietSignal61archiveMay 10
↳ replying to @RustMarble22

Not quite. Omega-3s are actually used to help gallbladder problems. Some fat is needed for the organ to work and pork fat is likely rougher than salmon. Oddly the opposite approach seems to help. After an episode I ate a fatty meal, took vitamin D, waited, then could exercise hard with no issue. Same today after a decent fatty meal beforehand. Whey shakes look like the trigger. Testing that tomorrow. Attacks only hit when the day starts with whey or whey plus browned-butter brownies. Might be wrong but that's what I'm sensing. Should know for sure this week.

PatientHarbour23archiveMay 12

Mine came out about five years ago during the sleeve. Fast loss can spark trouble but other things matter too, especially for women. The four F's: female, fat, forty or older, fertile.

QuietSignal61archiveMay 24
↳ replying to @IronAlder42

Problem seems handled or at least pushed down the road. Maybe this helps your daughter too. Did a refeed week eating near maintenance, skipped hard workouts, dropped the calcium, took K2 with D3, added three milligrams boron daily, increased psyllium. Taurine probably helped most. Started it for evening support but even normal doses made me run to the bathroom within five minutes on a full stomach, rumbling and loose for an hour. Not typical for taurine in healthy people. Turns out it pushes the gallbladder to release bile acids and that hits hard when the gallbladder is off. So I kept

PlainTimber26archiveMay 24

Had mine out in my forties. My brother-in-law the surgeon always said gallbladder disease follows the three F's: fat, female, forty. So if you're any of those and still have yours, count yourself lucky.

AmberCompass48archiveMay 24

Surprised I didn't jump in sooner. Gallbladder gave out after losing forty pounds in a few months, led to doctor visits and ER. Removed in February and feel way better now. Still get occasional pain where it used to be but it's fading.

SlowSignal40archiveMay 24
↳ replying to @PlainTimber26

Crap, I'm two out of three on that list, three if you count foolish. Scary given how many times I've lost twenty to twenty-five kilos in a month.

ClearBramble68archiveMay 24

In the club too, this was before any GLP-1, just from quick loss and fasting. Had several attacks before the big one. One hit on a cruise after months of strict eating then a week of overdoing it. Funny part, the final trip to hospital came after eating only some six-sided tortilla chips and salsa. Crippling pain, sweats, everything. Tried to sleep it off but had to give in. Huge relief once it was gone. Haven't missed it at all. Still hit the insurance deductible that year though.

WarmAnchor46archiveMay 24

Didn’t a famous person die from GLP gallbladder complications. Worth knowing if your gallbladder is already iffy before starting a GLP-1 plan.

QuietSignal61archiveMay 24
↳ replying to @WarmAnchor46

That was actually bowel obstruction from scar tissue after weight loss surgery. Ozempic can make one in a thousand people go blind, which is pretty funny.

LevelThistle44archiveMay 24

Already on taurine but wondered about any protective effects for the gallbladder. The AI brought up ursodiol as stronger but said taurine could work too. Glad I still haven't run into any gallbladder trouble.

WarmAnchor46archiveMay 24
↳ replying to @QuietSignal61

Interesting point. Thanks for setting that straight.

SlowSignal40archiveMay 24

Guess I have no choice but to go through with it now.

ClearBramble68archiveMay 24
↳ replying to @SlowSignal40

Pretty useless organ anyway. Maybe the surgeon would knock something off the bill if they took the appendix while they were in there.

QuietSignal61archiveMay 24
↳ replying to @ClearBeacon24

Guess you heard it here first then. You're welcome.

CopperSignal27archiveMay 25

Getting a real diagnosis matters. An upper abdominal ultrasound would settle whether stones are there, since they can block things and lead to serious inflammation or pancreatitis. The timing during a run makes me wonder if it's just a side stitch instead. Stone pain is usually intense, comes with vomiting, and hits after fatty meals, especially in people over forty who carry extra weight. Significant weight loss raises the odds quite a bit, so the scan is worth it even if the symptoms aren't textbook.

QuietSignal61archiveMay 25
↳ replying to @CopperSignal27

Not my style. I get those too and this feels different. It could definitely get worse if I kept going. Who knows for sure though. The pain lines up with what others describe on very low calorie days, so while waiting on a doctor I might try taurine, psyllium husk, and dropping extra calcium. After checking side stitches more, the kind of pain I'm having usually sends people in for a gallbladder check anyway. I'll sort it out once insurance kicks in and stick with taurine until then.

ClearAnchor21archiveMay 25
↳ replying to @QuietSignal61

You started this thread right when my own gallbladder flared again. I already knew I had a stone from an ultrasound years ago, before any weight loss meds. Occasional flare ups were manageable by skipping high fat foods, so removal never seemed urgent. On sema then tirz and now reta I stayed fine because I avoided the trigger foods. Then a two week trip walking everywhere in Europe brought the pain back after a couple hours on my feet. It eased once I lay down and didn't wreck my sleep the way food triggers used to. Next day it returned after more walking, so it really seemed tied to the movement. My own guess after searching was that gravity might be shifting the stone around.

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Exercise triggered gallbladder pain stones management options · ZyraTrack Community