Dosing titration strategies side effects and results for weight loss medication

Hey folks. I've been experimenting with this for seven months now. Started at three hundred thirty five pounds and now I'm forty three pounds lighter. As a guy who's five foot eleven, I do heavy lifting sessions no less than three days each week. Right now I'm in week five of twelve milligrams. Instead of weekly, I take it every six days since otherwise the day prior feels overwhelming with hunger signals. Both my scale and fitness tracker confirm I've gained roughly five pounds of muscle over this period, which makes the gradual fat reduction acceptable to me. Soon I'll begin another cycle of that other compound. My initial one was five months back, and I think doing a few rounds while shedding weight might benefit the skin aspect.

Right now my dosage sits at one milligram. I handle the shot on Friday nights. It's been three and a half weeks total. So far I've dropped around five pounds along with an inch and a half from my waist. This coming Friday I intend to raise it to two milligrams. The hunger control felt weaker this week than the prior two, yet the scale keeps moving lower.

Right now my weekly reta amount sits at 2mg. I began with 1mg and kept that up for a couple of weeks. Week ten is where I am at present. Everything feels really good! The side effects stay pretty low except for occasional skin troubles.

I kicked things off with half a milligram and kept that going for fourteen days, then bumped it to a full milligram which lasted another fourteen days, and just reached one and a half. Down the line I figure on settling somewhere in the three to four milligram zone.

I started out on half a milligram then moved up to one before reaching two. Each strength gets a full thirty days from me. Now I'm getting ready to step up further to three.

It's curious seeing so many individuals administer Tirz or Reta twice or three times throughout the week. I personally handle Sema each Monday and Reta each Thursday.

I began with ten milligrams per week not long ago. My dose increases have been ongoing from June onward. A month back I commenced lowering the amount of one to test whether the remaining one by itself can manage my urges around eating. Truthfully though I have no issue continuing with both of them indefinitely. This is the initial occasion in my existence where I feel calm regarding eating.

During the first three weeks I stayed at one milligram then moved up to one and a half in the fourth week. Right now the weight has been coming off at a steady one and a half to two pounds every seven days.

I've completed three weeks at the two milligram amount and now entering the fourth. Dropped eleven pounds during the initial pair of weeks followed by two more in the third. Thinking about moving to four milligrams on my next dosing day which is Saturday. Cravings for food have quieted down though I'm also sticking closely to proper meals. Hunger is present yet I could easily skip a meal without issue. The third phase study maintained the amount for four weeks prior to any increase. From what I've seen by the fourth week the full impact or stable level of two milligrams should be reached. Is it better to finish the entire four weeks here? Curious what others think. Really looking forward to stronger results on the scale but willing to wait as well.

Started using a glp1 for the first time and chose to ramp up slowly in order to minimize possible reactions. So far nothing negative has appeared. Doses went like this: half a milligram during the opening fortnight, three quarters during the next pair of weeks, one milligram at the five week mark, one and a half at six weeks, reaching two at seven weeks. Keeping the amount there now that pounds are dropping and everything feels fine.

I've noticed from various accounts that this compound often produces results at amounts below what the studies used. Perhaps the difference comes from many participants here beginning at lower body weights than those in the research groups. A heavier starter around three hundred fifty pounds might need nine to twelve milligrams to see changes due to overall size while someone near two hundred could get comparable outcomes from just two to four. At even lower starting weights like one hundred fifty the larger quantities probably wouldn't be necessary. This thought struck me after reading several reports and since I'm fairly new I could easily have the wrong idea.

About a year and a half back I used this medication once every seven days across roughly five months. That helped me drop around fourteen kilograms overall. I increased the amount bit by bit beginning at half a milligram until I reached two point five, which stayed my regular level for most of the period. Every so often I tried three milligrams yet that left me miserable so the next time I returned to the lower level. I tested dividing the amount into two separate doses across the week and also kept everything in one dose. One weekly injection suited me better overall. A single dose each week seemed to produce stronger effects.

I'm thirty three weeks in and just raised my weekly dose to 10 mg. Pairing it with 1 mg of another agent helps cut down on hunger pangs and food thoughts even more. I do the primary dose midweek and the add-on late in the week to get through the weekend easier. Weight comes off slowly for me, about half a pound a week typically, and I've got 45-50 more to drop. The add-on looks harder to find from nearby storage these days, making me eye the substitute instead.

Started with 2 milligrams each week, divided between Monday and Thursday in the morning, and kept that up for two weeks. Then went up to 4 milligrams weekly with the same division. Planning to stick with that for four weeks because that's the point where the leftover levels even out. Still undecided between moving to 6 or 8 milligrams next. Definitely feeling less hunger and no more constant thoughts about eating. Losing around two pounds weekly so far, though I could probably consume enough to stop that if I chose to or skipped exercise. Hoping the upcoming increase brings additional pounds off without needing to adjust anything else.

Got going with this today at one milligram. Another dose of the same size is lined up for next Thursday. That works out to one milligram each week across the first two weeks. After those it moves up to two milligrams weekly for four weeks to finish off the starting trial bottle. From there things stay open.

I began my weight loss path with those GLP medications back in January 2025 on a mixed version since I hadn't heard about the other option yet. I weighed 215 pounds at the start as a guy who's 5 foot 9 and 58 years old. After a full year I hit my goal at 165 pounds. Along the way I picked up knowledge about the alternative sources and ended up stocking quite a bit of the original med. The downside though is that plenty of what came off turned out to be muscle instead of fat. Not long ago I picked up some of the newer compound to test it out and now I wonder how things might have turned out if I'd started using that one earlier instead.

10mg weekly, no splitting.

I've recently begun a 1mg intake twice each week. Updates on any effects will follow.

My current schedule has me using 5.5 milligrams of reta on a repeating three-day pattern along with 1.25 milligrams of cagri at the same spacing. This approach produces a steady daily reduction near 0.23 pounds, which adds up to 80 pounds lost since July and leaves me at a BMI of 27.5. From the highest point back in 2020 the total drop now stands at 147 pounds. Working out the weekly reta figure starts with dividing 5.5 by three then multiplying by seven to reach 12.8 milligrams, yet adjusting for vials that probably hold 30 milligrams rather than 24 pushes the real weekly intake to 16 milligrams. I note the numbers each day and raise the amounts only when cravings for sweets reappear and the downward trend on the scale flattens. Now that both substances sit at their upper limits I plan to ease the doses lower across one month until reaching the lowest level I can tolerate without noticeable rebound, hold there for another month, then slowly raise them again to the smallest amount that still delivers results.

First two months I began with 2mg once weekly. Months three to six I raised it to 4mg. Then months seven to nine I dropped back to 2mg. Right now I'm using 1mg as my maintenance dose. I've lost 40 pounds and hit my target weight.

I switched from my previous 15mg dose of Tirz by slowly lowering it across four weeks: 12.5 then 10, followed by 6 and 3 before stopping entirely. With Reta I began at 1mg and stepped up through 2mg, 3mg to reach 4mg. For the current week I intend to hold at that 4mg level of Reta while adding half a milligram of Cargi around the middle and observe the results. Up to now I have dropped five pounds during the month once the plateau from Tirz ended. I will raise the amount only should progress stop again. Just to note, my starting weight was 295 back in November 2024 at the beginning with Tirz and I am at 216 pounds now with a target of 190, which feels within reach.

This marks week two for me with reta. I gave myself the 2mg shot earlier. Appetite dropped within two days of the first 1mg, so meals satisfied me quicker, though the effect began fading by day five. After today's dose, half a tiny pasta serving already left me stuffed. I even had to push myself to finish some bread and deli meat. Aside from that, everything feels fine. My partner received his second shot today as well. He noticed nothing different and reports no nausea. His appetite stays the same, so he could easily handle portions for two. I appear to be reacting strongly to reta and CU. CU produces no irritation whatsoever for me.

I've reached month three at this point and I'm administering three milligrams with three days between each dose.

My dose comes in at half a milligram once every five days. That works out near point seven milligrams across a week though half life factors keep it from lining up exactly. Thirty six year old guy here I dropped from two hundred eighteen pounds to two hundred three after a month. Body fat went from twenty six percent down to twenty three.

I started with a couple of weeks at two milligrams each week. Right now I'm taking four milligrams weekly, divided into two milligrams every Monday and Thursday. I intend to keep this schedule going for a total of four weeks before moving up to six milligrams for another four weeks and eventually eight.

Im in my 1st month, 2.5mg

I've reached month four using Reta, and right now my weekly amount sits at 3.5. Something closer to 4 or 4.5 feels like it might work better. The current vial is nearly empty, so my final injection from it will be 4. If that falls short I'll step up to 4.5. A couple weeks back I tried 5 and found it excessive. Adjusting to this takes time and trial. Over roughly two weeks I switched from every other day to a single weekly dose, which forced me to change my entire routine.

I'm at 3 mg.

I've started at five milligrams and plan to bump it up to six this coming week. I do my shots once every six days while hitting the gym four or five times weekly. So far I've shed sixty three pounds from my initial two hundred seventy down to two hundred seven now. My target is one hundred ninety to hit a normal body mass index range. On top of that I'm taking one point five milligrams of cagrilintide each week to help with the hunger signals.

Got going with this back on the twenty ninth of December twenty twenty five. My size isn't heavy yet the aim is bettering metabolic function across the board. At five foot ten and one forty pounds that one point five milligram weekly portion suits me fine.

I'm taking 2.5 milligrams each week right now. I increased the amount gradually starting from half a milligram, then three quarters, then one, adding more every seven days. Not many others follow this pattern and I don't claim it's superior or anything, it just happened to be my approach. So far I've dropped fifteen pounds which feels fantastic! Aiming for two hundred pounds total. Began around two hundred thirty two and this morning I weighed two hundred seventeen upon waking. Side effects only hit me one time, right after that initial two point five milligram injection, and they went away after twenty four hours.

Began treatment back on the twentieth of January dosing one milligram on a five-day cycle. Dropped four pounds up to now and intend to remain at this amount since only a little remains to shed. Each day I move from feeling hungry then satisfied quickly followed by dislikes toward foods which shows the compound is active yet this differs from my spouse on the other medication who hardly consumes anything and mostly rests. I enjoy keeping regular routines far more with this one.

My dose sits at four milligrams right now though I could possibly raise it a bit to four point five.

I'm remaining at the lower dose of point five milligrams and plan to raise it to one milligram after roughly two weeks.

I've been on this for six weeks and dropped seventeen pounds already. I took the one milligram amount the first month and switched to two milligrams the past couple weeks. Planning to stay at two for another fortnight before going up to three. Only problem so far is lousy rest, and that worries me if the amount increases.

Messed up my injection earlier this week after losing focus during the process so I probably ended up with five milligrams instead of three and now feel terrible.

I'm taking 5 milligrams of Tirz every five days right now, which works out to roughly seven milligrams each week. I'm planning to move across to Reta instead. My idea is to lower the Tirz amount down to four milligrams while starting with half a milligram of the new one. Then, in about two weeks, I'll reduce Tirz further to three milligrams and increase the Reta to one milligram. After that I'll check how things are going and adjust accordingly. Does anyone notice any issues with how I'm approaching this switch?