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3rd attempt with PT-141: The Adventures of the Perpetual Erection

14 replies7 peopleMar 16, 2026☆ Follow
Summary

What side effects and risks come with higher doses of PT-141, and how serious is a prolonged erection?

One user reported a 6+ hour erection, appetite loss, and next-day full-body aches after 2.5 mg. Others stressed the four-hour priapism threshold for seeking ER care and noted that PT-141 differs from melanotan. Some distinguished ischemic priapism from typical PT-141 effects and mentioned exercise or avoiding certain drug combinations as factors.

What this discussion establishesWhere people disagree

Whether a six-hour erection after PT-141 constitutes a true medical emergency or is usually benign compared with ischemic priapism

Still open

How common or dose-dependent the flu-like aches actually are

Nothing here is advice.

14 replies · 7 people
NorthLantern91archiveopening postMar 16

I had a tough time with PT-141 the other day and figured I'd share so others can adjust their dose more carefully. The first two tries at 0.5 mg and then 1 mg did nothing, so I went up to 2.5 mg. About 45 minutes later it kicked in hard. After taking care of things the erection just stayed around for roughly six hours, maybe longer because I eventually fell asleep. Appetite disappeared completely too, and the next morning I felt like I'd run back-to-back marathons with aches everywhere. Next time I'll stick to half-gram steps.

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GreenThistle75archiveMar 16

You should check the linked post and article I mentioned below. The titles leave out the key warning about it possibly being the last erection you ever have. Hope you dodged that, even though it's not exactly the same substance the mechanism might overlap. Be careful going forward.

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SteadyQuill55archiveMar 16

Is everyone here really experimenting with PT-141 without first looking into priapism and the rule that four hours means heading to the ER?

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NorthLantern91archiveMar 16
↳ replying to @SteadyQuill55

I did read about it and knew the four-hour ER guideline. This isn't my first time with something in this category, so the long-lasting effect wasn't a surprise. Everything is back to normal today.

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SteadyQuill55archiveMar 16
↳ replying to @NorthLantern91

I don't mind if folks handle things their own way, but it bothers me that more cautious men might come across accounts of an erection lasting hours, then nodding off, and treating the whole thing as amusing without realizing it could signal a serious health problem.

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NorthLantern91archiveMar 16
↳ replying to @SteadyQuill55

LMAO fair enough.

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SharpCinder28archiveMar 16

Overnight erections from PT-141 usually aren't the same problem as true ischemic priapism. The real risk comes from combining it with other drugs like trazodone or antipsychotics. The number of hours matters less for diagnosis than other symptoms.

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NorthLantern91archiveMar 16
↳ replying to @SharpCinder28

Yeah, when I tried Viagra years ago that erection actually hurt. This one was more just annoying than painful.

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SharpCinder28archiveMar 16

Lower-body exercise such as squats or using an elliptical might help relieve priapism.

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CopperMeadow64archiveMar 16
↳ replying to @GreenThistle75

Huberman was talking about melanotan. PT-141 is the FDA-approved version.

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SharpCinder28archiveMar 16

This compound got the okay from regulators for just one issue affecting certain females.

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SteadyKettle31archiveMar 16

I shot it into my partner the following time.

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NorthLantern91archiveMar 16
↳ replying to @SteadyKettle31

Since I was my own partner yesterday that tip wouldn't have helped. I basically held an orgy for one.

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SlowLedger42archiveMar 16
↳ replying to @NorthLantern91

Trying to square those two details. Are the full-body aches a direct side effect of the substance itself? I always figured they came from overexertion, but maybe that's wrong. Or maybe your solo session was that intense of a workout.

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NorthLantern91archiveMar 16

This started as a general warning to help others dose more safely but turned into oversharing. I wasn't expecting the extreme muscle soreness the next day, so I looked into it and found it's a known though uncommon side effect. One source even called it flu-like muscle aches, which matches exactly. All the soreness and the urge to stretch faded after a few hours.

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3rd attempt with PT-141: The Adventures of the Perpetual Erection · ZyraTrack Community