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Does everyone else on Reta Piss alot like me ?

13 replies12 peopleNov 1, 2026☆ Follow
Summary

Does retatrutide cause frequent nighttime urination and rapid overnight weight drops?

Users on reta report waking multiple times at night to urinate, sometimes seeing a 2 lb scale difference by morning. Some link it to dosage increases or fat metabolism, while others note it happens on any cut. Suggestions include watching fluid timing and electrolytes, though one person points out most fat loss exits as CO2 rather than urine.

What this discussion establishesWhere people disagree

Whether the urination is mainly from reta, general calorie deficit, or simply drinking habits

Still open

How much of the effect is directly caused by the medication versus other factors

Nothing here is advice.

13 replies · 12 people
NorthFenwick56archiveopening postNov 1

I'm taking 8 mg reta plus half a milligram of elora each week and the scale keeps moving down. I wake up at least twice, sometimes three or four times, to pee during the night, plus a big one first thing in the morning. That can mean a two-pound difference between bedtime and morning weigh-in. At almost sixty my bladder doesn't hold what it used to, so the trips are shorter, but the urge is still strong. Blood sugar stays between 5.4 and 5.8 and both glucose and blood pressure are better than before I started. I don't drink much right before bed. I'm wondering if the medication is making the liver convert fat into liquid that then has to come out as urine.

KeenSparrow66archiveNov 1

Same thing happens to me whenever the dose goes up, including one really long pee.

BrightCompass57archiveNov 1

I included electrolytes in my own batch as well.

GreyLantern71archiveNov 1

Roughly how many ounces of fluid do you take in daily? When I used to push extra water I felt like I was in the bathroom nonstop. These days I stay aware of intake but don't force it.

NorthFenwick56archiveNov 1
↳ replying to @BrightCompass57

Yep, I drink water with electrolytes during the day, though probably not enough of it.

SteadySparrow75archiveNov 1

I saw the thread title and figured it was a poll. I was ready to pick the standing-up option, or standing-up-like-a-boss if that was listed.

BrightCompass36archiveNov 1

Nighttime bathroom trips show up the same way whether you're cutting on reta or just dieting without any fat-loss drug. Stopping fluids four or five hours before bed can reduce it a little.

LevelThistle44archiveNov 1

Most of the lost weight leaves as carbon dioxide when you breathe, about five parts CO2 to one part water. Overnight, water vapor in your breath also adds up, and skin loses moisture through sweat too.

GreyLedger42archiveNov 2

Yeah I go often, but that's because I force down a lot of fluids. Each morning I stir protein powder, fiber and creatine into 72 ounces of water and knock it out by around 10am, which leaves me running to the bathroom nonstop all day. Those 72 ounces still only add up to roughly half my total daily intake.

WarmBramble71archiveNov 2

Honestly I haven't seen any shift in how often I need to go. The frequent trips come simply from drinking heavily. I've been cutting back on fluids in the hours right before bed like others suggested, even though it's tough because I'm genuinely thirsty most of the time. Still worth it to keep sleep uninterrupted.

PlainAlder11archiveNov 2

Has your prostate been checked? Mine was enlarged so I wasn't fully emptying my bladder and ended up waking three to six times every night. Taking some Tamsulosin (Flow Max) changed things a lot. I'm 67.

PlainAlder11archiveNov 2

Right, the problem began before I ever started Reta back in early January. I've dropped 60 pounds and am now on maintenance. I still avoid drinking much water after dinner, but that made little difference until I began the Flow Max.

GreenPebble13archiveNov 2

I sip water steadily all day and watch the color of my urine, keeping it very light yellow or nearly clear. With my evening supplements I take in about 8 ounces and stay up for one final bathroom visit. Even then the urge to get up is still there in the morning and the urine comes out more yellow by then.

SteadyCinder74archiveNov 2

Starting that treatment barely shifted how often it happened for me. Those two alternatives though really changed things up. My prostate is such a hassle.

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