The area under the curve stays the same either way. Splitting might let someone go higher with smaller peaks and fewer sides. It could also keep appetite control steadier by raising the low points without needing a bigger total dose. There's no real advantage either way in practice. I did weekly for three weeks then switched to split for the next eighteen. I've lost 55 lb overall with no real side issues and things are going fine.
I'm hoping to hear from people whose RS has used reta for a long time and has tried both weekly and split schedules on how well each works. Studies or other data are welcome but I'm mainly after personal reports. Did splitting change your fat loss results or not?