Forum › Dosing & Titration

HGH Usage- How much does your BS spike ?

23 replies11 peopleAug 30, 2026☆ Follow
Summary

How much does HGH raise blood sugar and what cancer risks come with long-term use?

Users report minimal or transient blood glucose increases at 2-3 IU doses, often returning to baseline within weeks, especially when already using GLP-1 agonists. Morning dosing can capture a short post-injection bump while bedtime dosing avoids it. Several participants cite strong correlations between elevated IGF-1 and higher cancer incidence or progression, while others argue GH is safe absent preexisting cancer and emphasize recovery benefits.

What this discussion establishesWhere people disagree

Whether elevated IGF-1 from HGH meaningfully raises cancer risk in healthy users versus whether benefits outweigh concerns when cancer is absent

Still open

Long-term cancer incidence and optimal monitoring protocols for sustained HGH use

Nothing here is advice.

23 replies · 11 people
NorthFenwick56archiveopening postAug 30

Nearly 60 and on 191aa for five weeks. Started at 1 IU around 7 a.m. and noticed it wiped out years of fatigue. Testosterone was already solid for my age. Suspect adult growth hormone deficiency but skipped the test since the peptide seemed low-risk. Worked well so I raised it gradually to 2.5 IU each morning. Recently started tracking glucose with a meter before the shot. Readings sit between 4.9 and 5.6 mmol/L. One Sunday it read 5.6 right after waking, took the 2.5 IU dose plus a couple other peptides, went back to sleep for two and a half hours, and the number was still 5.6 with no food.

SharpCinder28archiveAug 30

Lab work for glucose and fasting insulin looked unchanged, though we were already using GLP-1s. Main worry for ongoing use is prostate cancer and similar issues, so I quit HGH.

BrightCompass57archiveAug 30
↳ replying to @SharpCinder28

Growth hormone does not cause cancer. Without existing cancer there is nothing to worry about. Staying on it while watching health markers seems preferable.

SharpCinder28archiveAug 30
↳ replying to @BrightCompass57

A large study of nearly 400,000 people found higher circulating IGF-1 levels increase risk for several cancers.

NorthFenwick56archiveAug 30
↳ replying to @SharpCinder28

Appreciate the input. Read the linked study; 5.9 percent developed malignant cancer, which does not seem unusually high compared with general population rates. Background in statistics makes me cautious about outliers. Will keep researching the topic. Better to avoid turning this thread into a full cancer discussion. Were your glucose numbers unaffected while also on the GLP-1 and what HGH dose was in use?

SharpCinder28archiveAug 30
↳ replying to @NorthFenwick56

Yes, using tirzepatide above 5 mg along with 2 IU of HGH, though only for weeks at a stretch rather than months. Occasionally added Jardiance on top to limit fluid retention and support glucose control, but that combination felt like overkill.

CopperPebble16archiveAug 30
↳ replying to @BrightCompass57

Hard to know about undetected early cancer. Higher IGF-1 clearly speeds progression and raises death rates for many cancers. Levels seen in acromegaly or heavy recombinant use increase colorectal cancer risk by 2.5 to 4.5 times. IGF-1 pathway blockers are already main targets in oncology. The dismissal of the issue is widespread. Public announcements of diagnoses are rare and causation is seldom proven. One clinician who sees many bodybuilders notes unusual cancers in that group.

BrightCompass57archiveAug 30
↳ replying to @CopperPebble16

With that outlook it might be best to step away from peptides entirely. Vaccines caused far more issues than growth hormone or steroids. Regular blood work and check-ups are still done. No cancer means no problem.

NorthFenwick56archiveAug 30
↳ replying to @CopperPebble16

Anabolics sit in their own category even though they run alongside HGH. Plenty of knowledgeable users here, so I will leave that to them. Keep this thread focused on the original topic and move the IGF-1 cancer questions elsewhere.

WarmSparrow60archiveAug 30

Sixty days at 3 IU. Labs after two weeks showed normal insulin and blood glucose. Planning another set this week. Feeling good overall, with remaining midsection fat reduced. Less demanding than earlier tesamorelin runs. Will continue if blood work stays clean.

NorthFenwick56archiveAug 30
↳ replying to @WarmSparrow60

Good to hear. Three IU counts as modest. Let us know the follow-up numbers. Any sides noticed and what time of day is the dose taken?

ClearBeacon24archiveAug 30
↳ replying to @NorthFenwick56 (opening post)

Only saw an initial rise that returned to normal by week six.

NorthFenwick56archiveAug 30
↳ replying to @ClearBeacon24

Thanks. Was the increase small? Interesting that it normalized again. Is that typical? What dose was being used?

BlueAnchor59archiveAug 30

From what appears in discussions, the talked-about rise is usually a brief two-hour bump after the injection rather than an all-day elevation, and it scales with dose in the 2-3 IU range. Morning shots can make a fasting reading look higher because the timing overlaps that window. Moving the dose to bedtime often improves the morning number. Already being on reta helps keep glucose steadier, so holding at 5.6 with 2.5 IU is not surprising.

SharpCinder28archiveAug 30
↳ replying to @BrightCompass57

Possibly. Correlation does not prove causation yet the link to prostate, breast, colon and thyroid cancers is strong. No blood test can guarantee future cancer safety with ongoing HGH. The growth-promoting nature of the hormone makes the risk obvious to some. Benefits remain debatable when most users are already on GLP-1s or steroids that likely drive most recovery gains. HGH looks more like an add-on. Peptides mainly benefit testing labs that run IGF-1, insulin, A1C and glucose panels.

WarmSparrow60archiveAug 30
↳ replying to @NorthFenwick56

Dose taken fasted at 5 a.m., gym two hours later. Mild carpal tunnel appears but disappears once lifting starts. Managing water retention is necessary.

PatientHarbour28archiveAug 30

If fatigue has clearly improved, why increase the dose? It is already working. Raising it just to test glucose impact seems unnecessary risk. Stop second-guessing. Feeling better means it is doing its job. Get blood work for safety and keep enjoying the improvement.

BrightCompass57archiveAug 30
↳ replying to @SharpCinder28

Plenty of documentation exists. Years of use produced major recovery gains that support bigger muscle and strength progress over time. Effects show most clearly in dedicated trainees who can train harder and longer. Seventy-five consecutive days of two-to-three-hour sessions would not happen without it. Claims otherwise lack supporting evidence.

SharpCinder28archive3d
↳ replying to @BrightCompass57

Colon cancer rates are rising sharply even in people in their forties with no family history. Unknowns remain, but the connection between higher IGF-1 and these cancers is a legitimate worry. Recovery claims are still argued about on other forums because most HGH users stack other compounds. Clear benefits appear only at higher doses, yet the longer-term costs, especially heart and organ enlargement alongside high-dose testosterone, seem the larger issue.

AI summary: anabolic steroids and growth hormone carry risks of severe long-term organ damage while COVID vaccines show only rare acute events with very low overall incidence.

ClearAnchor21archive3d
↳ replying to @PatientPebble79

Thanks. Calling HGH safer than the COVID vaccine is one of the stranger claims seen here. Over twelve billion doses have been given worldwide with only a tiny fraction linked to injury, though that still equals many individuals. No comparable global count exists for HGH doses, so direct comparison is not useful.

ClearAnchor21archive3d
↳ replying to @AmberSignal47

Correct, changed to doses instead of people.

SharpCinder28archive3d

Forum reports mention colon polyps with HGH use. Separate data shows 38 percent of young adults who have polyps carry high-risk ones. Projections indicate colon and rectal cancer rates will rise sharply in the 20-34 age group by 2030.

Related discussions

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.