Users report sustained low readings such as 100/50 or 90/45 after starting these GLP medications, often tied to rapid weight loss. Several who were previously on BP drugs reduced or stopped them while monitoring readings multiple times daily and sometimes increasing salt intake. Dizziness on standing is common at first but can lessen over months; others view the drop as beneficial. A medical check is suggested if symptoms like fainting occur.
What this discussion establishesWhether the hypotension fully resolves long-term or requires ongoing medical attention
Nothing here is advice.
Low blood pressure at 100/50 while using tirzepatide and retatrutide. It started six months ago when I began the GLP medication. Has anyone else run into this side effect?
I notice it somewhat on plain Tirz alone, probably because I dropped a lot of weight and my doctor has not yet lowered my blood pressure prescriptions enough.
I stopped my blood pressure pills about a year ago yet readings keep falling. Average now sits near 90/45. I do resistance and cardio six days a week while taking tirz 10 mg and reta 2 mg each week.
I started tirz while taking four different blood pressure drugs. I did not want to wait for my doctor so I tracked my numbers three or four times daily and tapered everything myself to stay around 110-120 over 60-70 as weight came off. I only checked in with the doctor every six months. Six months later I am off all meds and stable near 105/70, sometimes 100/55 right after exercise. I also began adding salt again after thirty years of avoiding it.
It seems like a result of shedding weight fast. I felt dizzy often for a full year but that has eased now.
I began with hypertension at 145 kg on one medication. As weight fell my pressure dropped enough that standing made my vision go dark, so I measured and quit the drug once it stayed under 120/80. After further loss it has held at 105-110 over 60-65 for two years at 67-75 kg. The postural drop remains, so I stay careful when vision fades after standing. Research on weight-loss surgery shows this lowered pressure and postural effect is common and may not fully reverse, partly because gut blood vessels lose the support they once had from fat and abdominal pressure. The GLP drugs also lower pressure on their own. At that level a doctor visit makes sense, but action is only needed if dizziness or falls happen.
damn i wish i had that side!
The first four months I had to rise slowly or I would feel lightheaded. That has gone away for me.
Not sure this matches exactly what you mean. I microdosed compounded Tirz for about ten weeks and it worked well, quieting food noise. Then I switched to another version and tried half a milligram twice with little change, so I took a full milligram. The next day my blood pressure rose into the high range along with headaches. Six days later things have mostly settled. Reports suggest this reaction is fairly common during adjustment and I may simply be very sensitive since even the small dose affected me.
Postural hypotension. That term is clearer than the usual American label and far more precise than my usual phrase about passing out when standing too fast. I will start using postural from now on.
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