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MOTS-c dosing schedules experiences with NAD+ TMG and injection reactions

75 replies42 peopleOct 12, 2025☆ Follow
75 replies · 42 people · page 2 of 2
SteadyQuill18archiveApr 28

2 mg every two days.

SteadySignal83archiveApr 30

1 mg an hour before my workout, roughly four or five times per week.

SteadyQuill18archiveApr 30
↳ replying to @PatientSignal25

I do not think I have noticed much difference except feeling a bit less lethargic.

SharpHarbour41archiveMay 1

1.33 mg Monday through Friday.

SlowAlder75archiveMay 2

Has anyone found something that can ease the bloating and GI discomfort from taking Betaine Anhydrous or Trimethylglycine? I took one dose yesterday and my gut still feels distended and bloated. It does not seem to be gas related.

SlowAlder75archiveMay 3
↳ replying to @SharpHarbour71

If you have started NAD+ and are adding TMG, hopefully you are not also taking other methylators. I take methylene blue but only at a low dose of half a drop a day, and it is considered a methylator. Too much of a good thing can be an issue here. If you are using methylene blue you may need to cut back on TMG somewhat. You might also want to check other supplements since some B vitamins are methylated.

SlowAlder75archiveMay 3
↳ replying to @SharpHarbour41

Do I keep repeating this action without pause, or does it belong to a method that reaches completion on a set day?

RustSparrow99archiveJun 18
↳ replying to @NorthAnchor41

The link is not opening for me. Can you send it again?

SharpTimber80archiveJun 18

I have been taking 1 mg Monday through Friday and have not noticed much difference. Maybe I should have run SS-31 first.

WarmSparrow60archiveJun 19

5 mg every other day, alternating with NAD+ on the off days and never on the same day.

PlainKettle39archiveJun 19

5 mg every Monday, Wednesday, Friday morning for the past two weeks. No noticeable results yet.

QuietKettle32archiveJun 19

Taking two milligrams about sixty minutes ahead of exercise has improved my endurance after three weeks. Extra lifting sets come easier now and aerobic work feels less draining. This delivers steady vitality rather than the quick lift from stimulants.

GreenAlder78archiveJun 19
↳ replying to @NorthAnchor41

It is hard to accept this as meaningful. Maybe it is just the skeptic in me.

GreenAlder78archiveJun 19

Swollen spots that large sticking around for days on end? Did they spread across your whole midsection? Kept going with the shots anyway? That kind of thing would leave me totally alarmed. Even starting from just one.

ClearBeacon24archiveJun 19
↳ replying to @GreenAlder78

This could explain the reaction I had to histamines.

WarmSparrow33archiveJun 19
↳ replying to @ClearBeacon24

I love watching him. This cleared up a lot.

LevelBeacon74archiveJun 19

I plan on 2.5 mg on Mondays and Thursdays until the 20 mg is gone, then a four-month break.

PatientFenwick91archiveJun 19

Looking at the mice study converted to human dosing, most of us are way under. I am not going to inject that much though. Even the reference lists anti-aging protocols at 15 mg three times a week while 5 mg daily is called conservative. I am currently on 5 mg and my batch is not causing much injection site reaction. I intend to go up to 10-15 mg for the anti-aging effects and think I can tolerate it. I have epinephrine on hand if needed. I did two cycles of SS-31 at 5 mg a day before adding MOTS-c. Now I am on 5 mg SS-31, 5 mg MOTS-c, and 25 mg NAD+ five times a week.

ClearKettle55archiveJun 26
↳ replying to @PatientFenwick91

Interested to hear how the high dose goes. I did one 0.5 mg first to check for allergies, then two 1 mg doses for fasted morning workouts. The first two were intense with heavy sweating but this morning the 1 mg felt just okay. It is probably working in the background but for the fat burning effect I want I might increase by a mg or two.

LevelBeacon74archiveJun 26
↳ replying to @GreenAlder78

I was wondering about the time you lowered your intake. What quantity did that involve, over what period? Were there noticeable effects from doing so?

LevelBeacon74archiveJun 26

What level did you manage to reduce it to and were there noticeable effects?

ClearQuill84archiveJun 26

Started the cycle this week. I settled on 3.33 mg Wednesday, Friday, Sunday and want to run it for ten weeks to finish the whole kit. I reconstituted the vial with 1.5 ml. It gives three shots of 5 ml per vial. So far the only injection site reaction is itchiness right after the shot with no swelling, red patches or pain. The spot itches for a few minutes and that is it. I did not run SS-31 beforehand.

SharpHarbour41archiveJun 26
↳ replying to @SlowAlder75

Sorry I just saw this. I switched to 1.5 mg every day. Plan is to run four months, two-week break, then repeat.

NorthWillow72archiveJun 26
↳ replying to @ClearBeacon24

Enjoyed watching that clip. It had plenty of details. What caught my attention most was the image shown around the one minute fifty-five mark. Was it necessary for her to stay in that chilly space? Appreciate you putting it up!

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