Forum › Injection Technique

Ongoing injection site reactions with MOTS-c despite changes

10 replies6 peopleOct 19, 2026☆ Follow
Summary

How can injection site reactions from MOTS-c be reduced using saline bac water or KPV?

Users report mixed results when switching to saline bac water for MOTS-c and similar peptides like GHK-Cu, with some seeing milder redness but persistent issues. Adding KPV to the same syringe appears to lessen discomfort for a few, though others note the peptide still causes problems and may cloud in solution. Several participants highlight the risk of worsening reactions and advise caution or stopping use altogether.

What this discussion establishesWhere people disagree

Whether MOTS-c reactions are severe enough to warrant stopping entirely versus experimenting with dilution or add-ons like KPV

Still open

The longest safe duration anyone has used MOTS-c without serious issues

Nothing here is advice.

10 replies · 6 people
LevelThistle29archiveopening post9h

I read somewhere that saline bac works with some peptides including mots-c. Has anyone tried that and seen almost no site reactions? Same question for other irritating ones like GHK-Cu. I normally use a certain brand of bac and only get reactions from mots-c. Previously with another bac it was really bad, so I switched and this round started KPV along with SS-31. The reaction is milder now but still occurs.

SharpCinder28archive8h

One source suggests KPV works more as backup treatment after the shot rather than the main fix, which is really about how much you dilute or using a cream. I tried adding KPV mixed with saline bac into a GHK-Cu shot. It seemed to reduce any reaction, though I rarely got them with GHK-Cu anyway. Plenty of people just stop MOTS-c because of this. I have some set aside to test later and hope someone finds a better way for the regular version. Maybe other compounds could help indirectly too.

PlainAlder11archive8h
↳ replying to @SharpCinder28

I began this yesterday. Both were mixed with saline bac as well. Only a tiny red spot appeared overnight and faded by morning, though it felt a little sore at first. Two quick questions: do you pull them into separate syringes or combine them? And where do you usually inject? Apologies for taking over the original post.

SharpCinder28archive7h
↳ replying to @PlainAlder11

I put them together in one syringe, starting with KPV then adding the other. Not sure if injecting the area with KPV ahead of time would work better.

SlowLedger42archive7h

Has anyone seen a real change in reactions when using saline bac compared to the regular kind? For the tiny amounts most people use I would not expect much difference. I always figured the advice came from someone recalling osmotic pressure from school and guessing at an explanation.

SharpCinder28archive6h
↳ replying to @SlowLedger42

It does reduce the issue to some extent, but only goes so far with MOTS-c.

GreySparrow51archive5h

You may want to stop using it since reactions like this often get worse over time. This peptide is known to trigger severe allergic responses that need quick medical help.

SharpCinder28archive5h

If you have coverage you might obtain an emergency injector or the nasal version at no cost through a program on their site.

GreySparrow51archive5h

An injector only buys time so you still need to reach a hospital before it stops working, unless the reaction happens to be mild. In that case you might risk skipping care, but that is still a risk.

SharpCinder28archive4h
↳ replying to @GreySparrow51

It would be useful to know the longest period anyone has continued with this peptide. I would not even consider trying it if living by myself and would avoid intramuscular use. More details exist in the emergency resources thread. No reports of fatalities that I have seen, unlike with another peptide. That does not rule it out though. The worst outcomes might involve someone with breathing issues or doing an intramuscular shot right before bed.

PlainAnchor66archive4h
↳ replying to @PlainAlder11

Single syringe, KPV first then the copper peptide. I have tried different spots but the best tip was to use the glute area. That has worked for me and I no longer notice stinging or raised areas.

Related discussions

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.