ForumDosing & Titration

Should I titrate up?

17 replies8 peopleJun 17, 2026☆ Follow
Summary

Should I raise my retatrutide dose to control food noise while reverse dieting after major weight loss?

The original poster lost 20 kg on low-dose reta during a cut but now struggles with constant hunger and food focus in a reverse diet despite bumping to 4 mg weekly. Others note that reta typically curbs overeating by promoting fullness rather than silencing noise the way tirzepatide does, and that extra hunger often stems from the metabolic rebound after large weight loss plus increased training demands. Suggestions include verifying calorie intake against new activity levels, trying a single weekly dose instead of splits, adding low-dose tirz or cag for noise control, or simply accepting a modest increase in total food while tracking macros. Several users report that splitting doses can blunt effects and that higher single doses or combinations better manage cravings without eliminating the drive to eat.

What this discussion establishesWhere people disagree

Whether splitting the dose is helpful or counterproductive, and whether simply raising reta or switching/adding another GLP is the better next step.

Still open

What single weekly dose would be sufficient or when to stop increasing.

Nothing here is advice.

17 replies · 8 people
IronLantern42archiveopening postJun 17

Started reta back in January on just 1 mg weekly and dropped around 20 kg with almost no issues. Toward the end I moved up to 1.5 mg twice a week. Now I'm in a reverse diet eating more to regain muscle and strength. Hunger has returned hard. I can eat and feel okay for an hour or two, then the thoughts about the next meal start and I want to snack constantly, even if I stick to tomatoes. Tried 2 mg twice a week for the last seven days but the constant food focus hasn't eased. Thinking about going to 2.5 mg twice a week on Monday and Thursday. Is that unrealistic or should I expect the same easy control I had while cutting?

SlowSparrow49archiveJun 17

From what I've seen and felt myself, reta doesn't dampen food thoughts the way tirzepatide does, and that's actually useful because it still lets you eat enough while getting full faster. Since you're training more to build muscle you're probably burning extra calories, so your body may simply be signaling that it needs more fuel. Planning meals ahead and keeping sensible snacks ready can keep you from going overboard. Remember that gaining muscle means gaining some scale weight and requires a calorie surplus. A common error is keeping calories the same after ramping up training and shifting goals from fat loss to muscle gain.

IronLantern42archiveJun 17
↳ replying to @SlowSparrow49

I'm already seeing good muscle gains and steady weight increases, and my lifts are climbing fast. Still, the constant thinking about food is stronger now than it was during the cut when I lost the 20 kg. I was hoping a higher dose would quiet that background noise so I could focus on the surplus without the constant urge.

SlowSparrow49archiveJun 17
↳ replying to @IronLantern42

Double-check your intake numbers against the added training load. Raising the dose is an option, but reta isn't usually the one that turns off food thoughts. It could be that the weight-loss focus itself helped you mentally tune the noise out more than the medication did. Some people stack a low dose of tirzepatide or cagri on top of reta specifically for the noise reduction those compounds provide.

IronLantern42archiveJun 17
↳ replying to @SlowSparrow49

Maybe switching to tirzepatide or adding a bit on top is worth trying. I'll have to wait for it to show up, so I might keep increasing the current dose in the meantime.

SlowSparrow49archiveJun 17
↳ replying to @IronLantern42

My wife switched from tirzepatide to reta after losing a lot of weight. She notices she wants to eat more often on reta, yet when she tracks everything her total calories stay about the same and her weight holds steady. Eating six smaller meals instead of three larger ones might help manage the frequent thoughts. Everyone reacts differently, so do what fits your schedule. I don't get the noise myself, but once I start eating I tend to keep going, and reta has changed that for me.

IronMarble78archiveJun 17

Losing a lot of weight tends to make hunger return as the body pushes back. Stay consistent with the plan. Adding cagri or tirzepatide can help with the food thoughts.

IronLantern42archiveJun 17
↳ replying to @IronMarble78

Would it make sense to try 2.5 mg per injection and see what happens? Is there a point where I should stop going higher?

IronLantern42archiveJun 17

It's odd. I finish eating and ten minutes later I'm already thinking about the next thing, and the urge keeps growing. My stomach still feels fairly full though.

SlowAnchor19archiveJun 17
↳ replying to @IronLantern42

I've seen comments here that splitting doses makes the effects feel weaker than taking everything at once. Why split instead of one weekly shot? You could test a single larger dose before going higher. The studies used 2 mg, 4 mg, 6 mg steps, so 1 mg wasn't even the usual starting amount.

IronLantern42archiveJun 17
↳ replying to @SlowAnchor19

I thought splitting would reduce side effects, which is why I tried it. It would help to know the better approach now.

SlowAnchor19archiveJun 17

I started low and split doses early on to limit sides. After noticing weaker results I switched to one full weekly dose and have stayed with that. If it were me I'd finish the current week as usual, then take the next dose all at once at 4 mg and stay there for a week. Hard to tell how long you've been at 3 mg total, but one weekly injection seems to work better for me.

IronMarble78archiveJun 17

I'm on 8.5 mg tirzepatide right now and just added 2 mg reta. Planning to move to 4 mg reta while keeping tirzepatide at 7.5 mg to handle cravings.

WarmMarble23archiveJun 17

Been on 4 mg reta for five weeks. Lost the most weight at this dose but stalled last week and even gained half a pound despite daily surfing and lots of walking. Took the fifth shot last night and want to stay here a bit longer. If the scale doesn't move this week, should I go up or hold steady? I've dropped 8 % of my starting weight so far.

IronMarble78archiveJun 17

Track calories, figure out maintenance, then adjust downward to create a deficit.

PlainAlder11archiveJun 17
↳ replying to @IronLantern42

Is that meant to be 2.5 mg rather than written with a comma?

RustKettle57archiveJun 17
↳ replying to @IronMarble78

Do you feel like the combination produces more weight loss, or is it mainly for getting rid of the food thoughts?

CopperSignal27archiveJun 18

Extra hunger after dropping 20 kg is common as the body defends itself. There's no reason to avoid raising the dose until hunger is manageable. Most people can't stay very hungry for long without overeating and regaining weight. Even while trying to add muscle there's probably a middle dose that keeps hunger in check without letting it run wild.

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