Stacking Reta with Mazdutide, Cagrilintide or Tirzepatide: Motility Concerns

Fish oil helps keep me regular. Plenty of people stacking retatrutide with cagrilintide report solid results, so I plan to try that if food noise returns after switching from tirzepatide. I usually manage fine once I stay active and eat right; down 32 pounds so far.

There is a newer option some call a GLP-4 that mainly makes you feel full faster while eating, without broad appetite suppression or GI slowdown. Results vary by person and it is still very new. Oral tesofensine is another possibility with its own trade-offs.

Currently on 7.5 tirzepatide, 2 retatrutide and 0.25 cagrilintide. No side effects so far and the appetite control feels well balanced without needing to push food down.

Probably best not to worry until a problem shows up. Constipation is common but far from universal and usually easy to handle. Slow emptying at the stomach does not always cause constipation lower down. Without details on doses, current weight, age, time on retatrutide and so on it is hard to say more. Cagrilintide is the only one on the list that works through amylin receptors; the others overlap with retatrutide pathways, so raising the retatrutide dose first usually makes more sense than adding another agent.

Running 1.5 mg retatrutide weekly for over twelve weeks and it has helped drop seven pounds that would not budge despite lifting, running and steady steps. Also using GHK-Cu. Planning a twelve-to-fourteen-week break from both to avoid raising the retatrutide dose, then return to it later. During the break want to try low-dose cagrilintide for appetite plus mots-c a few times a week. Anyone combined cagrilintide and mots-c successfully for maintenance?

Cagrilintide acts on amylin receptors, not GLP-1, so the targets are different.

Thanks. Learned more since the first post. Tried a couple of sources for that new compound but both had manufacturing problems. Still waiting patiently; retatrutide has already made a big difference. Keeping up with weights and seeing natural gains from better diet and sleep.

Stacked for nearly two years without noticing extra motility trouble. It did get me to goal weight. Sometimes ran tirzepatide, retatrutide and cagrilintide together.