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Tirz plus testosterone? (Ftm)

18 replies12 peopleJun 19, 2026β˜† Follow
Summary

Does starting testosterone increase appetite enough to offset tirzepatide weight loss, and should the dose be raised or switched?

Users report a sharp rise in hunger after beginning testosterone, leading to modest weight regain even while on tirzepatide. Several suggest increasing the tirzepatide dose or considering retatrutide instead, noting that testosterone can also add water weight. Voice deepening from short-term testosterone is described as largely permanent once vocal cords thicken. Hormone effects on appetite and body composition are said to require weeks to stabilize.

What this discussion establishesWhere people disagree

Whether voice pitch will regress after stopping short-term testosterone

Still open

How to adjust tirzepatide when eventually tapering off testosterone

Nothing here is advice.

18 replies Β· 12 people
SteadyQuill17archiveopening postJun 19

Hello there, my treatment with Terzepetide started back in December and I'm currently at the 7.5 level while dropping pounds at a consistent rate. As someone who is nonbinary I began testosterone to lower my voice pitch and figure the course will last around six months since it won't be ongoing. I also use finasteride to limit any added hair growth from it. Yet once the testosterone kicked in my hunger levels turned extreme. Where I used to leave half a burger uneaten I now require the full thing plus fries and something extra right after. That shift produced a three-pound rise across the most recent three weeks or about one pound weekly. Would people here suggest moving up to the following dosage of Terzepetide? This feels like a pretty specific case but any thoughts would help. Thanks!

ClearBeacon24archiveJun 19
↳ replying to @SteadyQuill17 (opening post)

It appears the change might not be temporary after all. Checking on whether the body's own production comes back seems worthwhile since it may never happen.

GreyAlder96archiveJun 19

From what I've seen personally, starting testosterone therapy while keeping my male traits led to noticeably stronger hunger. Adding growth hormone then pushed that even higher. I've raised my tirz amount to hold the cravings down. On top of that, the testosterone tends to bring some fluid retention.

CopperMeadow83archiveJun 19

I'm unsure about what you're aiming for, but when focusing on building lean muscle, reta appears more suitable than tirz in my view. Quite a few weightlifters and bodybuilding enthusiasts opt for reta instead of tirz.

SlowLedger42archiveJun 19
↳ replying to @GreyAlder96

It appears the discussion covers moving from a regular guy into that alpha male role.

GreyAlder96archiveJun 19
↳ replying to @SlowLedger42

Same gender, just with the optional performance package.

SharpHarbour71archiveJun 19
↳ replying to @SteadyQuill17 (opening post)

oh wow that's noteworthy. once you discontinue the T your voice is bound to revert in pitch yeah?

GreyAlder96archiveJun 19
↳ replying to @SharpHarbour71

From what multiple ladies shared after overusing the steroid it became obvious those problems never reverse. Vocal cord thickening along with virilization effects stay for good.

SharpCinder28archiveJun 19
↳ replying to @SteadyQuill17 (opening post)

I think raising the tirzepatide amount makes sense, and dividing it across two days might reduce side effects too. There's still a lot of headroom with that medication since some people go beyond fifteen milligrams weekly. After mostly using tirzepatide myself for twelve months, I really enjoy retatrutide now. So yeah, moving over to retatrutide might be the next step for you eventually. I began combining both and then switched entirely to retatrutide alone. The clinical trial outcomes are pretty convincing. Maintenance doses of retatrutide as low as one or two milligrams work well for certain individuals. Cagrilintide or eloralintide could also be added to tirzepatide or similar glp meds. When beginning cagrilintide, one container lasts quite some time using three hundred micrograms each week. I keep my cagrilintide in a separate spot so I don't grab too much by mistake, mistaking it for something else. Since I've stopped the steroids, I prepare Asian-inspired meals to manage the hunger that sometimes returns before the next shot, especially if not splitting doses. My usual choice is noodles with a lighter sauce plus plenty of vegetables. Protein drinks that have over thirty grams also help when cravings hit in the evening. A plain baked sweet potato works too. When it comes to packaged snacks, I follow the idea that carbs and sugars make better occasional treats compared to fats. So my indulgences tend to be things like pretzels or licorice twists or a fruity beverage rather than baked goods with chocolate, at least until I visit the store again. While nuts and avocados provide good fats, watching the amounts is important. Being someone who eats mostly plants and fish, the time on steroids pushed me back toward eating more starches and bigger portions with fewer calories. For instance, a mix of barley and lentils gives solid protein along with fiber and carbohydrates. I still include one serving of less healthy food each day.

SteadyQuill17archiveJun 20

Everyone's comments mean a lot!! Really useful info 😊 Choosing to raise Terz levels while thinking about reta sometime later.

SharpHarbour71archiveJun 20
↳ replying to @GreyAlder96

Seriously confused by this. That medication isn't used in transitions. The person who started the thread mentioned testosterone during the relevant time.

GreyAlder96archiveJun 20
↳ replying to @SharpHarbour71

Compared to testosterone this stuff causes far fewer masculine side effects and many view it as appropriate for women. Still there are plenty of reports showing women end up with lasting changes from it. Therefore I feel it's logical to expect testosterone would produce identical lasting effects.

SteadyQuill17archiveJul 6
↳ replying to @SharpHarbour71

I'm on testosterone now and my voice has dropped for good according to what the doctor told me. It could only shift a bit higher if the cords hadn't finished changing before I quit, but it still wouldn't match how it used to sound. My sibling who is also trans used it briefly until money ran short and their voice remains low like an evening broadcaster even after several years. I'm trying to land somewhere in the middle range so a small rise in pitch wouldn't bother me at all.

SharpHarbour71archiveJul 6
↳ replying to @SteadyQuill17

From my own experience low testosterone makes my voice rise in pitch. It doesn't return to childhood levels of course yet it still sounds higher than normal. That probably explains why plenty of older guys without any testosterone end up with those squeaky tones.

BrightMeadow15archiveJul 19
↳ replying to @SteadyQuill17 (opening post)

Being a woman who wants to keep her female characteristics I began using testosterone cypionate within my hormone replacement regimen. Someone mentioned that hunger could increase. After starting my weight went up by five to seven pounds before leveling off. That matched what I expected. Once the extra pounds settled my desire for food returned to normal even without using any GLP-1 medication. Perhaps simply allowing time to pass handled the situation. Dealing with hormones resembles a gradual strategy game where you make a change then pause for twelve weeks before evaluating results. The effects ripple through the system so the body requires that period to adjust. After losing half my thyroid even with doctors aware of the replacement amount needed it required three months to reach the proper level. The same waiting period applies to hormone replacement therapy though reaching the dose happened faster leading to checks at three months rather than six. Losing part of the thyroid produced symptoms of low estrogen. It's surprising how these systems interact. Raising the GLP-1 dose slightly can assist in managing appetite. One thing I'm considering is whether reducing the testosterone means I should also lower the GLP-1 amount. It might require adjusting based on how things feel if eating stays under control then decrease the dose somewhat. Because testosterone cypionate lingers in the body for a while adjustments may need to happen gradually over weeks when stopping. Since GLP-1 medications need four weeks to reach steady levels there are essentially two waiting periods involved.

ClearLantern70archiveJul 20

Hormones seem pretty intricate for both guys and ladies, so probably even trickier when it comes to non-binary folks, or maybe just researched less thoroughly. I've noticed that asking lots of questions and picking up info here on the forum really helps in learning how to speak up about personal health needs. After gathering that understanding, I took it to my physician to get their input on it all. Following that, I figured out my own choice. Hoping things go well and that you'll share how it turns out.

GreenHarbour22archiveJul 20
↳ replying to @SteadyQuill17 (opening post)

I took part in the two discussions as a non-trans man and had the exact same idea concerning my hunger. Meals were eaten yet the scale showed less anyway. Prostate test results are why I quit testosterone.

RustAnchor34archiveJul 21

Loads of variables shape whether to take this route yet my background in the muscle building scene plus extended time on those compounds shows that proper handling makes the effort pay off.

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