Total Cholesterol Normal but Triglycerides high?

I follow a simple rule for sleep: if it doesn’t concern my doctor, it doesn’t concern me. My triglycerides rose roughly 100 points while on tirz, reaching 250. I think it may be tied to visceral fat shrinking and will check again once that fat is gone.

Refined sugar and carbs rank high among causes. No supplement will correct a poor diet. One sugary treat won’t move triglycerides much; the effect builds gradually. Fish oil might help lower them if you aren’t already using it, at 2 to 4 g daily, though anything over 2 g can thin the blood. Omega-3s boost LPL activity, which is often reduced in diabetes. My own triglycerides fell from 125 to 86 after cutting sugar while also taking concentrated fish oil. I’m on tirz and still have an occasional sweet once a week.

My diet has improved a lot overall. I already take fish oil and the snack had no refined sugar, just dates and wheat flour. The drop in A1C shows I’ve cut back on sugary items. I could try raising fish oil from 2,500 mg to 4,000 mg a day even if the brand is inexpensive. It still seems odd that the other labs improved while triglycerides stayed roughly the same.

Triglycerides in the 300s count as high. It could be the retatrutide releasing stored fats into the blood as you suggested. Waiting another month to recheck makes sense. It’s also worth asking your doctor about medication options to bring the number down even if you end up not needing them.

As a health professional I’d say LDL matters more than the total. Under 100 is fine. Triglycerides only become a real concern once they hit 1000 or above.

CJC/IPA also helps release fat, so I wonder if that plays a role too. My LDL looks good. Since I’m only two months into these peptides I’m hoping the numbers settle with more time.

Are you carrying extra weight? Starting reta two months ago suggests you had weight to lose. The starting A1C was mildly elevated and the triglycerides fit a metabolic syndrome picture. LDL probably matters more for long-term heart risk and any statin decision. A mildly elevated triglyceride level by itself usually doesn’t need special treatment beyond fish oil or icosapent ethyl. I expect triglycerides to keep falling as you lose more weight on reta. Checking blood pressure is worthwhile. You’ve already moved out of the prediabetic range; reta should continue to help prevent diabetes just as tirzepatide does.