CommunitySide Effects

What is a side effect you enjoy?

26 replies25 peopleJul 13, 2026☆ Follow
Summary

What positive side effects have people noticed while using tirzepatide or retatrutide?

Participants report mental quiet from absent food noise, reduced cravings for alcohol and other substances, emotional blunting that eases bipolar or anxiety symptoms, steadier energy and focus, and shifts like feeling colder or less bothered by mosquitoes. Several tie these changes directly to improved daily life, work, and relationships without framing them as medical advice.

What this discussion establishes

Nothing here is advice.

26 replies · 25 people
CopperMarble58archiveopening postJul 13

Following the thread title, combat PTSD leaves me with hyper aggression, constant vigilance, impulse trouble, and random irritability. What stands out is how little any of it bothers me now. My head feels calmer and more peaceful than it has in twenty years.

AmberCinder18archiveJul 13

The quiet around food thoughts is the biggest win. I never grasped the phrase until the first shot, when my mind suddenly went blank and still. It feels like I have spare brainpower sitting around that could tackle anything.

SlowLedger31archiveJul 13

After a rough stretch these last few years, not caring about much has been a relief. I also have steady energy and stamina through the day, hit the pillow on time, and wake up alert with good focus and clarity.

RustQuill94archiveJul 13

It leaves me feeling a bit energized in a way I enjoy. I accomplish more and my thoughts stay clearer. I have not tried the other option yet, but this one works well for me.

WarmCompass44archiveJul 13

I have lost interest in phone games. That leaves more time for workouts and family. My wife appreciates not hearing me say I need to finish a round before helping with something, and there are other upsides too.

NorthWillow72archiveJul 13

Feeling satisfied with a smaller steak instead of needing twice as much counts as one, right? I like that change.

ClearQuill84archiveJul 13

I have not run into any side effects though.

SharpTimber40archiveJul 13

The flattening of emotions has been helpful. As someone with bipolar, it has turned out to be one of the better ways it has been managed.

ClearLedger33archiveJul 13

The complete drop in interest in alcohol stands out. I sometimes think about the flavor of a drink, yet watching others deal with the aftermath makes me glad I skip it. Not getting drunk has become the new way to have fun.

GreenBramble30archiveJul 13

I have taken the same ADHD medication daily for five years. After starting this new one about a month ago I have not needed the old prescription for most of that time. It has handled the focus issues on its own at a low weekly amount.

ClearLantern70archiveJul 13

When I feel bored I no longer reach for food. Instead I head out for a walk.

GreyThistle69archiveAug 1

Bugs seem less drawn to me now, which feels like a small miracle given how things used to be.

BlueThistle84archiveAug 1

The drop in pleasure response has cut down on old habits. With a history of chasing highs, this has made it simple to skip weed and similar things without feeling the pull.

CopperAlder51archiveAug 1

I have dropped alcohol, weed, sugar, chocolate, adult content, and nail biting. I am unsure whether to take vows now or once I hit my goal weight. I have also lost my temper almost entirely and almost nothing gets to me anymore, except maybe supply issues.

GreenBramble47archiveAug 1

I am not sure if it is listed anywhere, but my worry level has dropped a lot lately. I cannot confirm it lines up exactly with starting this, yet that is when the change became noticeable.

BrightCompass57archiveAug 1

Some mention a burning skin sensation, but mine feels more sensitive in a pleasant way.

AmberCompass37archiveAug 1

It is odd because I usually chase dopamine hits due to ADHD, yet lately I have not been looking for them. I feel a bit bored but not really bothered by it. I just moved up in dose so I am adjusting, with some skin sensitivity and almost no appetite.

SlowBramble67archiveAug 1

The best part so far is hearing jealous comments from people telling me to stop dropping weight.

SlowBramble67archiveAug 1
↳ replying to @WarmCompass44

That change sounds helpful for your partner as well.

SteadyTimber22archiveAug 1

During the months I used it I felt chilly most of the time. I kept a sweater on indoors and did not need the air conditioning as much once warmer weather arrived, running it about ten degrees higher.

KeenCinder20archiveAug 6

With depression and anxiety in the mix, the reduced emotional response has been useful. I used to feel too nervous to go out alone, but now I simply do what I want without overthinking it.

SteadyQuill58archiveAug 6

I consume less than half the alcohol I once did, which is a clear improvement. My husband is glad the constant feeling of being overheated from perimenopause has gone away. It is winter here and I stay cold, yet that lets me enjoy cozy clothes and pajamas again. I also feel less anxious overall.

WarmMeadow92archiveAug 6

Drinking less has been noticeable. I did not consume much before, mostly while traveling, but now one glass is enough even on the road.

LevelLedger10archiveAug 6

The slower stomach emptying has removed the sudden need for a bathroom after restaurant meals, something that started after gallbladder surgery a while back.

WarmMeadow92archiveAug 6
↳ replying to @LevelLedger10

I have had the opposite experience with bathroom issues from the slower emptying, and lately my nose runs after any meal no matter the size. It feels like everything now triggers it.

SlowKettle77archiveAug 7

I paused once I hit my goal weight, yet I miss the absence of food thoughts the most. Even when other urges appeared I could set them aside and concentrate better, which made work and projects much easier to handle.

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