Which did you feel less tired on and had more energy - Reta or Tirz?

Tirzepatide left me exhausted. Retatrutide was much better, though maybe that was just from eating more sensibly.

Same thing happened to me. I would not call it extra energy though, just not as drained.

Quick comparison from my short time on each. Tirzepatide hit my appetite hard at first, then the effect faded so I had to raise the weekly amount. I never felt good on it because low food intake left me low on energy and unable to follow my plan. Nausea the day after dosing also killed my desire to eat. Retatrutide at just 1 mg weekly for five weeks gave me better mental control over eating without blocking the amounts I needed. Energy stayed steady, no nausea or food aversion, and I noticed stronger fat loss, possibly from expecting it. I feel good so far.

Neither one affected my energy. It might simply come down to how much I am eating. I went from 2.5 to 7.5 mg tirzepatide over six months, then added retatrutide in two stages: first 5 mg tirz plus 2 mg reta, now 2.5 mg tirz plus 4 mg reta. I train every day and have not seen any drop in energy or extra tiredness.

The first week or two brought a lot of fatigue that later eased. Part of it was probably higher daily burn; I aimed for maintenance but started losing because the medication raised expenditure around 15 percent. I also discovered I can no longer train fasted the way I used to. Now I get hungry in the morning and feel weak if I lift without eating first. Checking the size of the deficit before changing drugs might be useful. If that fixes the tiredness, great; if not, at least you know more before moving to retatrutide.

I have not tried tirzepatide, but retatrutide drops my energy hard above 4 mg for the first two or three days after the shot. The tiredness then fades. It does not seem tied to food; the drug itself just wears me out. By day five or six I feel normal again, right when it is time for the next dose. Weight loss is still good though.

Thanks everyone, some useful points to think about. Glad to hear slow increases are working when only needed. Reading and listening to experts, it seems many people raise doses too quickly and lose weight faster than intended. I only have about ten kilos left to drop after the four I have already lost, so staying slow makes sense. Hearing that mental control over hunger is stronger on retatrutide is exactly what I want long term, even after hitting my goal. It could be something I cycle on and off for life. What maintenance dose are you using? How do the two recent combinations compare for you in appetite or energy?

Honestly I have felt no difference at all while trying to move across. Appetite and energy stayed the same. I was stuck at 100 kg despite training seven days a week and thinking I was in a deficit on tirzepatide, which is why I added retatrutide. I do not weigh often, so it will be interesting to see if anything changes. Separately, bloodwork showed high bilirubin that had been overlooked; after starting retatrutide the level fell 25 percent toward normal. I had heard it helps fatty liver, and it may be helping mine quickly. Next test is in two months after about ten weeks on retatrutide.