Dosing titration strategies side effects and results for weight loss medication

Update after week six at 2 mg once weekly. 5'9", 52-year-old male, started at 208 lb now at 188 lb, 20 lb down in six weeks. No need to increase yet. Food noise is completely gone even with ice cream, cashews and low-fat mozzarella around. Normally January to April/May I lock into clean eating and drop the same 20 lb then rebound. This time the urge for cheats or rewards is absent and food feels heavy or not worth it. Plan to drop to a micro dose after week eight once I near the 175 lb goal.

Third 4 mg dose on Friday hit appetite hard. Need to find something besides beer, which I enjoy, since I've already cut about 80 % of my usual intake. Went out for lunch and was full after two wings and three beers. Supposed to cook salmon and salad but no interest. Also drinking a lot of water which fills me up. Any thoughts on that?

I began low, adding 0.5 mg weekly while still on 5 mg Tirz, then adjusted up and down. Once Tirz was stopped I settled at 4 mg Reta weekly and dropped 23 lb in a month. I see no reason to go higher soon. At 180 lb with near-normal BMI I now use 1 mg each of Tirz and Reta to stay consistent.

I have stayed in maintenance for ten months at 2 mg weekly. Lowering to 1 mg or spacing to every two weeks did not work as well, so I returned to 2 mg each week and occasionally add Cag to quiet thoughts.

I began on 2 mg weekly from January 11 and have stayed consistent. A plateau happened during a holiday with extra food. Approaching 50 and always skinny-fat, this is my first GLP-1. So far it limits muscle loss well while weight drops. I will soon move to a lower maintenance amount for continued appetite control and body recomp.

Week seven at 3 mg every five days. Considering adding 1 mg Tirz for better appetite control.

Today marks the second month. I used 1 mg for four weeks, 3 mg for five weeks, and moved to 4 mg a couple days ago after a few weeks without loss. Hoping I can remain at this level.

Week eight at 5 mg, dosing once every six days. Considering moving to 7.5 mg after the next 5 mg shot.

Week twenty at roughly 7.5 mg. Began at 2.5 mg, reached 5 mg after four weeks, then 7.5 mg after another four weeks. I wish I had titrated slower because lower doses were already working. I plan to hold here until a clear plateau appears.

Just finished the fourth 4 mg shot on Friday. After weighing this morning and seeing only a one-pound drop I am still thinking of moving to 5 mg next Friday. No problems with the 4 mg shots so far.

Third shot was yesterday at 1.5 mg. First two were 1 mg then 1.25 mg, all on Sunday evenings. Only notable side was nausea on the first Monday.

My research subject has used Reta for about five months and is now at 5 mg every third day, past the halfway point of the process.

I am at 2.5 mg every five days. Weight and metabolic markers are at maintenance. Planning to switch to Tirz because even this low Reta dose raised resting heart rate by 10-12 bpm, which I do not like or consider healthy long term.

Over three years on Reta but keeping weight stable at 2.5 mg weekly for maintenance. I could probably go lower but it provides a buffer, especially when I bulk for physique work.

Three weeks and two days in at 2 mg weekly. Will move to 4 mg next week for four weeks, then continue the pattern. So far weight has gone from 164 lb to 151 lb.

Just increased to 6 mg weekly with very few sides so far. Ordered labs to check.

Four months in, down 25 lb, currently at 1.6 mg but planning to increase next week. Effects were noticeable even at the low dose because I am very sensitive to medications.

Started November 30 2025 at 1 mg with no noticeable change, possibly from impatience. Moved to 2 mg for three weeks, then 2.5 mg for two weeks, 3 mg for five weeks, and 4 mg in February with no plan to go higher. The reason for the last step was hearing that full effects begin at 4 mg. I intend to remain here for a long time. Age 55, started at 275 lb, now 224 lb. Recent labs through the VA show all markers improved; previously cholesterol and A1C were off and I had refused medication. This has made a real difference.

First four weeks at 0.5 mg, weeks five through seven at 0.75 mg. Total loss so far is 11 lb with very few sides. Slow and steady approach. Started at 219 lb.

Weeks 1-5 at 2 mg, weeks 6-7 at 1 mg to check hunger signals and loss rate (still steady but slower with more hunger), weeks 8-9 back at 2 mg. A couple pounds from goal so will drop to 1 mg for two weeks, then 0.5 mg for two, then 0.25 mg for two. After that I may test 0.1 mg once or twice weekly to finish the vial and ease any hunger. Reference: 17 lb loss in nine weeks with muscle sparing and even some gain.

Probably too much.

Starting week four on Monday at 0.5 mg twice weekly. Down 4 lb with no sides. Looking forward to raising the weekly total.

Yes it is.

Took 2 mg for the first time today. Planning to stay at 2 mg for the next three weeks, then move to 4 mg weekly next month to see how it goes.

After six months on Tirz up to 6 mg weekly I took a few weeks off for digestion to normalize. Then started Reta at 2 mg week one, 3 mg week two. Will probably hold at 3 mg another week or two before going to 4 mg for a month, then possibly 6 mg depending on tolerance.

I began with 2 mg for the opening four weeks. On the fifth week I moved up to 3 mg. The first two weeks at the starting dose brought bad insomnia, zero appetite, and constipation. The next two weeks food noise returned mid-week, so I added 1 mg hoping it would help without repeating those early sides.

My Reta run began February 27, so just over a week in. I opened with 1 mg but splitting it twice weekly works better for me. It does not wipe out food noise completely yet it is plenty so far. This also stretches my 5.5 mg supply until the next order arrives.

I began end of November at 0.5 mg and titrated every two weeks: 1 mg, then 2 mg, then 3 mg, then 4 mg and stayed there over five weeks total. Two weeks ago I moved to 5 mg. In the second week of the journey I added a low dose of sema four days after the reta shot. Feeling very good at the moment and still have 15 kilos left to lose.

Thirty-seven days in and holding at 2 mg with a lot of weight lost. Eating and drinking feel a bit harder but I am managing. Reta really does change your life because the binge-eating disorder is gone.