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Adding tirz on Reta

8 replies7 peopleJan 21, 2026☆ Follow
Summary

Should someone add low-dose tirzepatide to ongoing retatrutide for extra appetite control and anti-inflammatory effects, and how fast does it work?

Users report mixed experiences with stacking the two. One person added reta to low-dose tirz and saw extra weight loss but also low blood sugar and dehydration risk. Others note tirz appetite effects can appear within hours to a couple days, while some prefer sema instead or avoid stacking altogether to preserve glucagon action. A few run both successfully with near-zero hunger.

What this discussion establishesWhere people disagree

Whether tirz, sema, or neither is the better add-on to reta; some avoid any GIP agonist while others combine without issue.

Still open

Optimal timing to start the add-on before travel and long-term safety of the stack.

Nothing here is advice.

8 replies · 7 people
WarmHarbour15archiveopening postJan 21

On 6mg Reta right now and results are fine so far. Reached 10.5 earlier without trouble beyond skin sensitivity. Instead of increasing the dose more, thinking about adding 2.5 tirz to get the anti-inflammatory effects plus stronger appetite control. Planning to start it when leaving for vacation so nothing extra needs to be packed. How quickly does the added appetite suppression from tirz show up and does this seem like a reasonable plan?

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NorthCompass34archiveJan 21

I went the other direction and added reta on top of tirzepatide that I kept low, never above 5 mg. The 2.5 reta helped finish the last 10 lbs but produced a couple low blood sugar events, with one reading at 45 mg/dL and averages around 75-85 while on both. Tirz is said to suppress appetite within 12 hours yet mine started around 4 hours. Also note the higher risk of dehydration and blood pressure drops because it reduces thirst along with hunger.

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LevelThistle44archiveJan 21

When is the vacation? The 2.5 mg tirz peaks around 24 hours but the appetite quieting can take a couple or few days to appear, especially without prior steady levels. If planning ongoing use, why wait until travel? Cagri might work more as-needed for hunger but still needs most of a day to reduce appetite.

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ClearMeadow20archiveJan 21

Adding sema to reta fits better since it avoids interfering with the GIP receptor.

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WryBramble37archiveJan 21

I switched straight from tirz to reta. Appetite control dropped but I would rather keep the glucagon effects instead of diluting them with another GLP.

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AmberCompass48archiveJan 21

I run both split-dosed and hunger is basically gone. I still feel like eating at times but it is simpler to decide when and what.

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WarmHarbour15archiveJan 21
↳ replying to @LevelThistle44

Vacation is the week of February and only five days long, so the idea was to take the tirz just before leaving. Tried cagri twice and it caused bad fatigue even at .25, which stopped eating but is not something wanted while traveling.

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BrightSignal73archiveJan 29

Sema seems like the better choice. Planning to try it since cagri no longer does anything.

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BrightSignal73archiveJan 29
↳ replying to @BrightSignal73

Sorry, meant tirz would be better because of the GIP action.

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