Selank intranasal effects administration and alternatives for anxiety focus and depression

Which ones do you like? I have only tried Semax in a blend with Selank and Selank alone. None of them impressed me much.

I work full time as a software engineer. Ranking my nootropics by effectiveness, the top spot goes to sub-hallucinogenic doses of pharmahuasca using 5-meo-dmt with an MAOI. The risks, sourcing hurdles for most people, and required diet changes make it hard to recommend. Next come creatine and high-dose EPA fish oil. I keep a steady 6G+ total Omega3 intake daily in liquid form. For creatine I use the liposomal version twice a day with good hydration. If you are not already doing these basics then focus there first. Other mentions include Tropisetron, Mag-L-Threonate, BPN-14770, Clomipramine, JNJ-42165279 and Tak-653.

Is this meant to replace Semax for ADHD? I do not see that working for anyone I know who is not already on medication.

Check the comment I'm addressing here. Someone wanted to know which cognitive enhancers I prefer, so my earlier reply matched that exact question.

What the heck is an SWE?

Software engineer.

Oh, that is what I thought it meant, but my brain was trying to tie it to healthcare somehow.

Yes, I realized what it was answering and just found it funny because my ADHD family would never stick to a routine like that. I am sure many people find your response helpful.

Ah I misunderstood. I did not mean to sound overly strict or too dialed in.

Just to clarify up front, I am asking this out of genuine curiosity with no negative tone. Your first post seemed to say Semax and Selank are mediocre and that better options exist for similar benefits. The follow-up post about your favorites did not clearly connect back to replacing Semax or Selank. Do you have any nootropic suggestions that would directly outperform them in your experience?

Man that comment jumped topics like crazy. Started out on DMT then shifted straight into creatine and fish oil.

DMT at sub hallucinogenic doses taken orally modulates the 5-ht2a site. That is strongly pro-cognitive and the MAOI keeps the molecule from breaking down. I could not work on high dose DMT. Since that may be too far for most people, a solid alternative to Selank is NSI-189 taken with Magnesium L-Threonate. Some compounds now in development for fragile x look interesting, especially zatomilast which seems to boost dendritic density. No RCTs exist yet in healthy humans so I hesitate to endorse, though caregiver ratings and coding scores are positive. If you want to go further there is nightly vTNS. I am also using a fair amount of tropisetron lately.

I wrote a very lengthy reply and it got rejected by the anti-spam filter then disappeared. I will keep this short. Selank's exact mechanism is not fully known but it ultimately increases BDNF. That is not always beneficial. Upregulating nrf2 and trkb pathways to raise endogenous glutathione seems better for BDNF. For noise I prefer guanfacine and l-theanine over many anxiolytic RCs I have tried. Guanfacine is remarkably pro-cognitive. For a direct swap in place of Selank try NSI-189, now called ALTO-100 or similar. I am not as enthusiastic about it now but brain scans showed it repairs and increases hippocampal volume in both healthy and depressed volunteers. When I used it I felt very sharp and not depressed. It is currently in phase 2 trials.

I came here to say the same.

Wow, never realized folks tried tiny doses of DMT until now. Always picking up fresh info each day. Do you keep homemade tracking sheets in a spreadsheet program for these compounds? I maintain similar ones for peptides, just for kicks.

Does anyone feel like looking over the peyote psyllium husk and hemorrhoid cream mix that I put together?

I had success using nasal versions of two compounds against the mental cloudiness that stuck around after COVID when things stayed fairly light. The usual approach calls for muscle shots if that option fits what someone can handle. Research is also exploring a certain peptide paired with a related molecule for similar effects, though fewer papers exist and nothing has involved human subjects yet.

I wonder whether obtaining this without a prescription would be okay safety wise. Back when I checked before I figured there was just one firm making it somewhere in Europe. Moderators I can assure you I was not looking for any places to acquire it this is purely a question about safety.

I got mine from the authorized producer and found it available without any doctor's note through various online shops beyond the states. It arrived as the genuine article sealed inside the proper container along with the official directions. Since the product is sold across around fifty nations they end up manufacturing quite a volume of it.

I appreciate the warning. It wasn't my goal to ask for a source and I'm sorry if my words came across that way. That wasn't what I meant.

Anyway it's alright. This isn't purely a peptide though it works more like a blend containing enzymes peptides and amino acids. The material comes from pig brains after enzyme processing and includes several nerve growth factors such as the brain derived the glial cell line derived the nerve growth and the ciliary ones plus unbound amino acids together with different small peptides.

Anyone have encounters with freeze-dried cerebroprotein powder from China? Spotting them around makes the price gap versus cerebrolysin look appealing.

This has nothing in common with the real version. The item in question delivers almost no noticeable results. Sellers are simply looking to grab a share of the market for themselves.

For the past fourteen days I've been injecting this compound under the skin daily but I notice zero changes even though I'm using a substantial amount each time. There's simply no effect at all. I'm planning to switch over to the version that goes in the nose instead. If someone has a preferred way to prepare it or a good mix with salt water I'd appreciate hearing about their experiences with that. I should mention I also take another medication prescribed by my doctor which works really well for me but I have to watch the amount carefully because exceeding my limit leads to strange mood drops in the afternoon. I thought this new one might provide some benefit but up to now it hasn't done a single thing. Perhaps using it nasally will make a difference.

I wonder if this question crosses a line but were you generally pretty nervous before you began taking it?

I looked over an online calculator that lets you input the desired concentration for each nasal spray and then works out the proper blending amounts. Registration was necessary to access it, but the tool proved quite handy for handling dosage and reconstitution figures right away.

It works that way sometimes. Little problems would annoy me and I'd focus too much on each one. The steady calm lets me concentrate without wanting to handle several tasks simultaneously. This has helped me become kinder toward unpleasant people.

In my experience this works better when taken through the nose. The results tend to be mild no matter how it's used. My homemade nasal version provides five hundred micrograms with each spray to reach one milligram and I used the unmodified form. Nasal delivery worked better for me due to greater absorption compared to under the skin shots that go through the liver first.

Did you experiment with adamax as well, or was semax the only option?

I returned to this place to express my gratitude. Using it through the nose turned out to be entirely unlike the previous method and far stronger in its impact for me personally. The shots under the skin for more than fourteen days produced zero results. Right after the initial nasal application, I experienced a feeling of calm and uplift. My thoughts started to notice and value numerous small daily pleasures that I typically overlook, including hues and noises, along with ideas, future ideas, and individuals. This allowed me to recognize more than ever before how I've probably been dealing with a constant mild sadness. It felt as though the glass had been polished. Although I've continued with nasal use over several days, and no session equaled that initial one, they all provided similar overall benefits. I truly believe this substance is reshaping my mind. So I appreciate all those who recommended it. Amazing.

Thanks for sharing that!

My original post on the intranasal reconstitution process is in another thread. I used the same steps for Epitalon, Semax and Selank plus the NA versions. I also deal with ongoing sinus issues. BPC and TB are large molecules so they probably won't cross the BBB easily, but they should still help topically with sinus inflammation, so you might be onto something. TA-1 and KPV have been used for that too and I made a combo spray with them, though they target viral issues more than the usual bacterial sinus infections and the combo didn't do much for my last one.

You can clean the bottle and sprayer with alcohol or hydrogen peroxide. I fill it halfway, spray a few times through the mechanism, let it sit ten minutes, then rinse with saline and let it dry. You could go further with UV or autoclaving if you wanted, but I've never had a problem. My sprays have stayed clear for thirty days refrigerated and I'm still fine.

Wondering if you could mention how you measure out those two compounds. What quantities for each? Mixed together inside the nasal device or kept apart in separate ones? Everyday use without stopping or occasional pauses instead? Also awaiting another peptide from the bulk order soon. Can't wait to check if it eases my persistent memory troubles.

I create a nasal spray with twenty milligrams of that peptide and take one milligram per day over twenty days usually upon waking until depleted. I follow a similar pattern with the other peptide except I have tried thirty milligrams to cover thirty days and I keep the modified version in that size. Following completion I pause for a minimum of two weeks although extending it would be preferable. The first peptide gets cycled on a four month interval. Separate delivery devices hold each one. Despite working together well I separate their applications by thirty to sixty minutes. A new peptide is arriving soon featuring an adamantane addition to enhance uptake. Nasal delivery fits it well due to the compact dimensions. Typical amounts fall between five hundred micrograms and two milligrams so I begin at the lower level. Its effects accumulate thus I advance slowly and carefully continuing four to six weeks. No research on humans has been done yet but a particular paper seemed noteworthy.

I want to try p21 after that.

Thoughts on Ceroxtin?

That's what I'm after. I lie down to sleep and then the list of things starts running.

I experimented with different versions of those substances. A couple of them produced no noticeable effects for me at all. One stands out as completely distinct though. I've used that one over the past five months and it's made a huge difference in my life. Now I can just relax inside my thoughts without doing anything else. There's no urge to occupy every second or to tackle issues before they arise.