Reta is making me unable to eat

you went too hard, too fast. Dial it down a bit—even dosing every 7 days would be fine, but every 5 days right at the start is too much. Drink some protein shakes so you’re at least getting something in and make sure you stay hydrated.

Effects hit their maximum after a month so I kept the level unchanged throughout that period prior to any increase. I used one milligram over those four weeks then checked if more was required since that quantity proved adequate 😊

I think my head was blowing this out of proportion too. I just stayed calm and let a few days pass, and everything settled into the updated routine.

I went through something similar and then it changed. I started back in Sep 2025 using 0.5 then 1.0 for about a month and so on. Eventually I started getting hungry again around day 7, so I split the dose with 1.5 on Mon and 2.0 on Thur. I don’t get the every-5-days approach. I would move to every 6 days or split accordingly.

2 mg every 5 days works out to roughly 2.8 mg per week. That’s still not a huge dose, but it’s a big jump from 1 mg every 6 days. Clearly you’re responding strongly. Is this your first GLP? Why did you shorten the interval and raise the amount? When I overshoot, appetite flattens too much and eating becomes a chore. The fix is simply to lower the dose. I haven’t run into actual food aversion.

So is the goal to never feel hungry again? I still get hunger on 7-8 mg of reta once per week and I’m still losing weight.

I split doses starting in my third week on tirz because food noise returned. I switched to reta a couple weeks later and kept splitting. Injecting the same two days each week is easier to schedule than rolling days.

I started at 2 mg for 4 weeks and even after the first shot both my wife and I noticed appetite suppression, though not extreme. The next rounds were 4 mg, and after the third one it hit harder. I think I was drinking too much water and felt full without wanting dinner. I cut back on water today to see how it goes. Beer also fills me up faster than before. You really want to stay on one dose for 4 weeks before increasing.

I would stick with a simple weekly schedule. Don’t change the dose until after 4 weeks. It looks like you could have stayed lower if you had waited. Reset to your original weekly amount for 4 weeks and go from there. Keep it simple.

If side effects appear, wait until they fade before the next dose. It’s that straightforward, even if it means waiting two weeks for levels to drop. Then use a plotter to see what blood levels corresponded with the bad symptoms and the recovery, so you know exactly which levels to target or avoid. Later you can nudge the dose up slowly if hunger returns, but sensitive users should increase in tiny steps like 10-20 % per week. If that feels too involved, just wait out the side effects, drop the dose, and titrate extra slowly. Peak effect hits about 24 hours after injecting and levels halve after roughly a week.

If the lower dose was already working, try dropping back to see if the nausea stops. I began at 2 mg per week with no nausea and no appetite, then after 6 weeks moved down to 1 mg per week. It’s still effective—I’m losing weight and have little appetite, yet enough to manage one meat meal daily. Some of us are hyper-responders, which is great for cost.

Little update: I went back to 1.5 mg every 6 days. Nausea has mostly disappeared, though eating is still difficult and foods I liked now taste bland. I feel okay otherwise except still struggling to drink enough, but at least I can force down some protein again. I finally weighed myself and hit 69.2 kg today—almost 10 kg down in 24 days.