I wish I could fall into that top group that drops forty-five percent. I have lost thirty-four percent yet my BMI still puts me in the overweight range. At five foot six I now weigh two hundred fifteen pounds. My wife thought I looked too thin back in two thousand eight after I dropped forty pounds down to one hundred eighty. My target was one hundred ninety. The scale has not moved since around May twenty twenty-five. Right now I am combining one milligram of one medication with five milligrams of another to try to get things moving downward again, and it seems to be inching along slowly.
Some people on these medications keep asking to remain on them for just a bit more time, which creates a real ethical bind for the prescribing doctors. We have moved from shortages to having too much supply available, along with issues around eating disorders. In my work I see most patients drop 10 to 20 percent of their starting weight in six to twelve months and hold onto most of it while staying on treatment. About five percent get little or no effect or cannot handle the side effects at all. Another five percent lose more than a quarter of their weight, and I have seen losses as high as forty-five percent. Genetics probably play a role in why some respond strongly or barely at all, but there is still no simple lab test to forecast the outcome ahead of time. Everyone even