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My biggest GLP-1 ethical problem: patients who don’t want to stop

53 replies26 peopleFeb 20, 2026☆ Follow
Summary

How should doctors handle GLP-1 patients who refuse to stop treatment after major weight loss?

Doctors face an ethical bind when patients push to stay on GLP-1 drugs indefinitely, fearing regain or loss of benefits like reduced food noise. Many users report 20-45% weight drops and view the medications as lifelong tools for a chronic condition rather than short courses. Concerns about body image issues or shifting to undereating are raised but often downplayed in favor of patient autonomy and real-world results. Prior non-drug attempts at major loss frequently fail because they demand ongoing mental effort that eventually fades.

What this discussion establishesWhere people disagree

Whether physician reluctance reflects genuine Hippocratic caution around disordered eating or mainly self-protection from future lawsuits.

Still open

How to identify who will need lifelong therapy versus who can eventually taper, and what maintenance protocols work best long term.

Nothing here is advice.

53 replies · 26 people · page 1 of 2
SharpCinder28archiveopening postFeb 20

Some people on these medications keep asking to remain on them for just a bit more time, which creates a real ethical bind for the prescribing doctors. We have moved from shortages to having too much supply available, along with issues around eating disorders. In my work I see most patients drop 10 to 20 percent of their starting weight in six to twelve months and hold onto most of it while staying on treatment. About five percent get little or no effect or cannot handle the side effects at all. Another five percent lose more than a quarter of their weight, and I have seen losses as high as forty-five percent. Genetics probably play a role in why some respond strongly or barely at all, but there is still no simple lab test to forecast the outcome ahead of time. Everyone even

GreyMarble12archiveFeb 20

I wish I could fall into that top group that drops forty-five percent. I have lost thirty-four percent yet my BMI still puts me in the overweight range. At five foot six I now weigh two hundred fifteen pounds. My wife thought I looked too thin back in two thousand eight after I dropped forty pounds down to one hundred eighty. My target was one hundred ninety. The scale has not moved since around May twenty twenty-five. Right now I am combining one milligram of one medication with five milligrams of another to try to get things moving downward again, and it seems to be inching along slowly.

CopperSignal27archiveFeb 20

This comes from an endocrinologist working through these questions in real clinics where there is still limited research on what happens after the weight comes off. His views seem shaped by older standards where holding a five to ten percent loss counted as a strong outcome for health. That bar has moved, and bigger drops like twenty percent are now achievable for many who can tolerate the drugs. I keep noticing how few people here report getting stuck halfway to their target after losing around twenty percent, even though studies suggest that should be common. Even with people combining different versions the pattern is not as frequent as expected. There is still room for thoughtful guidance from doctors who know the history of what was possible before.

SteadyQuill83archiveFeb 20

I see the issue from both sides. I dropped thirty percent of my weight in a year on one of the medications and have moved into a holding phase. I probably should be slowly lowering the amount to keep from dropping further while eating normally again. Instead I am adding more calorie-dense foods to stay steady because I cannot bring myself to cut the dose. It feels like a mental block more than anything else.

LevelTimber64archiveFeb 20
↳ replying to @CopperSignal27

I follow your point and where you are coming from. The piece does not strike me as overly controlling. It reads more like a doctor trying to stay true to the basic ethical pledge they take. There is tension between backing these medications for the strong results many see and watching for cases where success turns into something else. Body image problems are real, and so is disordered eating. People who never imagined escaping obesity are now seeing changes they could not picture before. It is easy to go from a helpful tool to overdoing it. I do not know the writer personally so I cannot speak to their style or motives, but it is possible they are simply worried about long-term patient well-being. There is more I could add but it would give away too much in a space where I like to stay private.

WryLedger88archiveFeb 20

The eating disorder side is complicated. I am not sure the medications create these problems or simply become another method for people who already lean that way. Long-term overeating was harming me and food acted like a drug. Yet eating too little can harm as well. Just as we allow overeating, people should be free to undereat if they choose. A doctor may not want to enable extremes, but in this middle ground no one can block access to the prescription anyway. The same way no one could have stopped me from buying and eating during my own food struggles.

SlowLedger42archiveFeb 20
↳ replying to @LevelTimber64

I had the same two reactions at first. After more thought I realized that as a specialist practicing here he is probably using careful wording without even noticing how it shapes his stance. He carries malpractice coverage but will still want to limit any future legal exposure for himself or the clinic above all. That priority can sit above ideal care when the two pull in different directions. In an extreme case a patient at very low BMI demanding more could lead to a lawsuit later if something went wrong. Doctors rarely say outright that they are refusing to avoid being sued. They frame it instead as their own clinical judgment.

SteadyQuill55archiveFeb 20

It feels strange to hear talk of stopping when we basically know that leads to regain. Lowering the dose makes sense, but full stop? Why go through the whole cycle again in another year?

IronThistle42archiveFeb 20
↳ replying to @GreyMarble12

I face a similar spot where goal weight and being told I look too thin arrived before BMI reached the healthy range. At five foot eleven I am down to one hundred eighty-five pounds and still register as slightly overweight by BMI. My focus is heart health so the number makes me uneasy, yet my girlfriend says I am getting too thin and the mirror backs her up. I have switched to using waist-to-hip ratio instead, aiming for around point nine zero for men. I sit at point nine eight. Because I naturally have less in the rear I am now doing heavy hip thrusts at the gym to build that area rather than shrink my waist further, and it is starting to show after two months.

WarmHarbour28archiveFeb 20
↳ replying to @SteadyQuill55

Do you think this group of us even registers with practicing licensed doctors? We collect plenty of data by managing ourselves. Yet I doubt any doctor could legally sit here and gather what we share.

SlowLedger42archiveFeb 20
↳ replying to @SteadyQuill55

That framing comes from these drugs being newly approved for weight issues. Companies know more people will try them if they are seen as a short course that ends once the weight is gone. Right now the goal is getting insurance plans to cover them at all, and a temporary story sells easier. Once coverage is widespread the push will shift toward official positions on ongoing use, because reversing coverage later becomes politically difficult.

GreenSignal76archiveFeb 20

I have no interest in stopping even though I reached my target. Figuring out a solid maintenance amount is tricky, and I hate the return of hunger feelings.

WryLedger88archiveFeb 20
↳ replying to @GreenSignal76

I am with you on planning to continue. I can still eat when I choose on the medication. I am currently not moving on the scale but I could also gain if I decided to. It gives me the choice to eat only what I need, which feels like a big improvement.

GreenSignal76archiveFeb 20

Completely agree with that view.

SharpCinder28archiveFeb 20
↳ replying to @SteadyQuill83

We do not need your success stories spoiling our fun with plain broccoli sandwiches. The doctor’s remark about social events struck me as odd too, since many diets already limit social eating, including vegan ones for ethical reasons.

BlueMarble65archiveFeb 20

I have passed the forty-five percent mark she mentioned, yet I still get how the mind adjusts more slowly than the body does. Someone who stops drinking still calls themselves an alcoholic. In the same way people who once felt overweight may keep that sense even after the numbers change.

SteadyQuill55archiveFeb 20
↳ replying to @WarmHarbour28

Yeah but the big trial happened and everyone saw the outcome. They act like it did not occur, which still surprises me.

ClearThistle50archiveFeb 20

I wanted to quit but the effect on my inflammation has been striking. Another compound might help with that but I mainly want to keep the reduction I have. I will stay with the gray market route for that purpose.

CopperAlder51archiveFeb 20

These medications offer more than weight change. Losing the urge to drink ranks almost as high for me as the scale. Other unwanted habits have faded since starting one version. I have said I will keep some on hand for life because of that effect alone, even if I could hold a healthy weight without it, which seems unlikely.

AmberAnchor10archiveFeb 20
↳ replying to @SharpCinder28 (opening post)

I am exactly the kind of patient the article describes.

SlowLedger42archiveFeb 20
↳ replying to @SteadyQuill55

You are pointing to one trial result. That alone does not set everyday medical practice. The main professional group will wait for several studies or whatever they count as enough proof before writing guidelines. Those guidelines then define standard care. I expect they will reach that point once most insurance plans offer at least temporary coverage, because at that stage reversing course becomes harder.

BlueKettle13archiveFeb 20

I intend to keep going. The past six months have been a huge relief from constant thoughts about food. That noise used to be nonstop and I had to fight the urge to snack all the time. I could finish a meal feeling full and be ready for another one two hours later. Now I eat when and how much I want. Even apart from the twenty percent loss so far and the hope of another fifty pounds, the mental break around food has been worth it.

WarmHarbour28archiveFeb 20

It is interesting. I have never been good at thinking far ahead. I also have little respect for decision-making by committees and have always felt their collective intelligence works in reverse.

LevelTimber64archiveFeb 20
↳ replying to @SlowLedger42

Prescribing these drugs to someone at a BMI of fifteen would be clear malpractice in my view. Looking out for oneself is normal of course. There is only so much I feel comfortable saying in this setting. I hear what you are saying.

WarmWillow50archiveFeb 20
↳ replying to @CopperAlder51

This matches my experience too. I am not an alcoholic but I had a strange repetitive behavior that has disappeared while on the medication. I did not even notice until my partner pointed it out. There really are side benefits that go beyond the weight change.

LevelTimber64archiveFeb 20
↳ replying to @SlowLedger42

I think of it as the system finally treating obesity as a lasting medical problem with real related conditions instead of just a personal shortcoming. Too often the attitude is still that people should simply eat less and move more. At my highest weight, deep in treatment-resistant depression and fresh trauma, a nurse practitioner told me to just go outside and walk. I could barely leave the house and was barely functioning. I had already canceled that appointment four times before I finally showed up.

WarmMeadow92archiveFeb 20
↳ replying to @SharpCinder28 (opening post)

Good article. The part that stood out was the claim that only five percent do not respond or cannot tolerate any version. I suspect the real share is higher, and the doctor may have picked five percent just to indicate a small group. The trials show bigger dropout rates, with one losing eighteen percent of participants and others over twenty percent. Not every dropout is due to side effects, but most probably are.

CopperAlder51archiveFeb 20
↳ replying to @WarmMeadow92

I thought I saw somewhere that thirteen percent stopped because they lost more weight than intended. Might not have been the same study. That is a modern-world issue.

BlueAlder12archiveFeb 20
↳ replying to @IronThistle42

At six foot one and one hundred eighty-five pounds in high school I did not see myself as skinny even though I played football. Looking back at photos many of us were still boys rather than grown men, with shoulders not fully developed. In that light BMI numbers are pretty flawed. That is why I am aiming closer to two hundred twenty as a target weight, or maybe two hundred ten to two hundred fifteen if training increases. I am also someone without much in the rear area.

BlueAlder12archiveFeb 20
↳ replying to @SharpCinder28

Try cream cheese and cucumber sandwiches instead. They are good. When I was in active loss mode on one medication I made what I called a salad wrap, just grabbing some greens, adding hot sauce and a bit of feta, rolling it in a tortilla. Simple and quick.

WarmMeadow92archiveFeb 21
↳ replying to @CopperAlder51

Now that you mention it I recall some dropouts in the retatrutide trials happened because the loss happened too quickly rather than because too much came off. Still, that group was small and most left because of stomach side effects. In the semaglutide trials discontinuation from adverse effects ran around six to seven percent. Losing weight too fast or too far is definitely a first-world type of problem, and I would not be on that list.

ClearWillow37archiveFeb 21
↳ replying to @WryLedger88

I do not think these medications cause eating disorders. They act more like a trigger. People who already had tendencies toward overeating can get hooked on the satisfaction of watching the scale drop. If the emotional reasons behind the original gain are not addressed, the pattern just shifts to a different extreme.

ClearWillow59archiveFeb 21
↳ replying to @BlueAlder12

High-fat foods will not help her health. Lean proteins would be a better choice.

CopperSignal27archiveFeb 21

Binge eating and food addiction are by far the most frequent eating disorders and affect a sizable share of people with higher weight. There are surprisingly few studies on how these medications affect that pattern, but the limited data suggest they may be the strongest option available while also addressing the weight itself. The only approved drug right now is one that does not work very well. Most existing research comes from a therapy angle using behavioral methods that also show limited success. Because the fields stay separate it may take time for targeted studies to appear.

WarmMeadow92archiveFeb 21
↳ replying to @ClearWillow37

I agree they do not create eating disorders, yet they can make disordered patterns worse for someone already at risk. Strong appetite reduction can leave people eating too few calories or developing unhelpful habits around food. I find binge eating patterns interesting. Although I do not have it myself I have seen many accounts of people using these medications successfully for it even without official approval. For most the core issue is psychological, tied to loss of control and emotional triggers rather than metabolism. Still, if I had that pattern I would want to be on one of these drugs whether or not I carried extra weight.

SteadyQuill55archiveFeb 21
↳ replying to @WarmMeadow92

That is me. Long history of binge eating that sometimes improved but never fully resolved until this medication ended it completely. I have not had a single episode or even had to fight the urge since starting. Therapy did not help. A twelve-step group helped only a little. Nothing that did not require total focus every single day made a real difference except this treatment. It fixed the problem and I am fine now.

CopperSignal27archiveFeb 21

Much of my thinking comes from personal experience. I believe that in cases of severe obesity the normal appetite controls are largely broken. I reached one hundred forty-five kilograms and was in a difficult living situation after my business collapsed and I had to sell my house. That low point pushed me to make changes. I started a diet of low-fat, low-glycemic, mostly low-carb high-protein foods to avoid swings in blood sugar or other signals that drive appetite. At the time I thought these medications were out of reach. It worked. I stayed hungry but not out of control and reached seventy-five kilograms in under a year. The key was avoiding any high-calorie high-glycemic rewarding foods entirely, because even small amounts used to trigger extreme hunger that was hard to manage.

WryQuill22archiveFeb 21
↳ replying to @ClearWillow37

One person promoting one of the newer versions has become fairly well known. I mostly hear about it here and on forums, yet even my brother knows about the individual who uses another substance for a sharper jawline. I am not sure if that counts as an eating disorder or something else, but it is notable.

SlowLedger42archiveFeb 21
↳ replying to @CopperSignal27

That sounds close to what I did after a diabetes diagnosis to bring weight and blood sugar under control. Mine was not low-fat but we each have our own ideas of a useful eating pattern, and almost any structured approach beats the usual everyday diet. I think binge patterns often trace back to how easily available highly engineered foods trigger addictive responses. Some people have stronger natural resistance than others. In your case changing the foods you kept around lowered the pull to binge even when hunger was present, because the hunger did not carry the same addictive force.

NorthThistle70archiveFeb 21
↳ replying to @WryQuill22

That would be the person known for a very defined collarbone area. Reports say he broke his jaw for the look or used one stimulant, though some claim another. He was recently arrested with a fake ID and a stimulant without a prescription.

NorthThistle70archiveFeb 21

I always get the strongest pushback when I say changing daily habits is still the main goal. No one wants to do the actual work of adjusting what they eat and how they move. Those steps bring the lasting gains.

SharpCinder28archiveFeb 21
↳ replying to @NorthThistle70

The resistance makes sense. These medications ease the strong hunger and food thoughts that make clear thinking difficult. It is hard to build lasting habit changes when the body is in a stressed state. Everyone here has already tried diet and exercise before. I do not see the medications as a simple add-on. They function as ongoing treatment for a chronic issue. A better eating pattern and regular movement still help, can improve lab results and blood pressure alongside the drugs, and may allow a lower ongoing dose. Strength work also protects muscle.

WarmMeadow92archiveFeb 22
↳ replying to @SharpCinder28

The medical field is moving toward seeing obesity as a lasting condition rather than a character issue. Society lags behind. For me the medication corrects an underlying metabolic problem. Stopping would likely return me to my earlier state. I have dealt with this my whole life and know long-term use is what I need, even if others with milder issues might manage without it.

CopperSignal27archiveFeb 22

I know how difficult it is to keep large weight losses without these medications. I reached sixty-five kilograms in two thousand thirteen from one hundred twenty or one hundred thirty and held it for two years. Eventually I could not keep avoiding the foods that triggered me. The same thing happened again in two thousand twenty-two to twenty twenty-three when I went from one hundred forty-five down to seventy-five and maintained for a year. After starting one version I finally felt full enough to leave food on my plate for the first time. I dealt with nausea for a year to get lower hunger, then found other sources with stronger appetite control and fewer side effects. Surprisingly I am still losing slowly, one hundred to two hundred grams a week, without constant effort. At sixty-six kilograms and a BMI of twenty-four I am unsure where to level off. Eventually loss will stop on the current amounts or I will need to lower doses.

SteadyQuill55archiveFeb 22
↳ replying to @SharpCinder28

I agree. I do not argue online with people who repeat the lifestyle change line unless I am being paid, and in daily life there are too many conversations I would rather have. The phrase sounds motivational but really means eating less than you strongly want every single day while ignoring the desire to eat the amount you actually crave, because you cannot outrun intake. So when someone says these medications let you change your lifestyle we are all on the same page, yet the constant upkeep part gets ignored. There are rare people who can do it without ongoing effort, but that is not most of us.

CopperSignal27archiveFeb 22

Almost everyone here has lost weight at some earlier point without these medications. It is not that difficult if you commit to a plan for a while, and nearly anyone can do that temporarily. The real issue with the lifestyle advice is not that it fails to work but that it requires nonstop mental work. If you could keep the pattern without constant effort you would not have been obese to begin with. Over time that effort fades for almost everyone. If new habits form that no longer need constant attention then the problem is solved, but research and most personal stories show how rarely that happens. When appetite controls cannot handle constant access to high-reward foods the only option without medication is ongoing effort that eventually runs out. These medications remove the need for that constant mental load beyond the injection itself.

SlowLedger42archiveFeb 22

One detail often overlooked is that not every restricted way of eating requires fighting hunger the whole time. Simple calorie cutting is usually the hardest and most likely to fail because you keep the same tempting foods and just try to eat less of them until you give in. Anyone who only tried that approach can be forgiven for thinking diets never work. Low-fat plans are a step better, focusing more on whole foods and fewer refined items. There is an adjustment period for giving up favorite processed foods, after which you can feel full while losing, though true satisfaction may stay missing. You feel the absence of certain foods more than raw hunger.

CopperSignal27archiveFeb 22

I fully agree with looking for an eating style that manages hunger without constant portion control, since constant restriction is difficult and usually does not last. Low-carb approaches have the benefit that ketones can reduce appetite and steady blood sugar and related signals make sticking to the plan easier and prevent big hunger swings. Some of the original thinking behind one older low-carb plan was on the right track even if it oversimplified things. Continuous glucose data now shows how high-calorie foods can cause spikes followed by drops that increase hunger, which matches ideas from decades ago. The challenge is that higher-fat eating often means higher calorie density, so portions stay small.

SharpCinder28archiveFeb 22
↳ replying to @SlowLedger42

That is how I see it. If the typical diet is meat and potatoes, some plans cut the meat and others cut the potatoes and bread. The middle option is the Mediterranean style often recommended by heart groups. Also worth noting that two people can eat identical meals and have very different hormonal reactions.

SlowLedger42archiveFeb 22
↳ replying to @CopperSignal27

I appreciate the detailed reply and agree with most of it, with only small differences in opinion on certain foods. I especially like how you framed whole fruits and vegetables rather than just talking about fiber. A couple of points I might question: even though it seems counterintuitive I would group both low calorie density plans and most Mediterranean approaches under the same low-fat style experience, because both tend to leave you full yet not fully satisfied. That was my experience too.

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