Users report that 1 mg reta is too low for meaningful effect and hunger returns mid-week. Combining with a small amount of sema can reduce hunger pangs because the two act differently on GLP-1, but most advise raising reta first to at least 4 mg before stacking. A few people already run higher reta or tirz doses together successfully and see no food noise.
What this discussion establishesNothing here is advice.
Normally I take reta Monday morning at 1 mg, but by Thursday evening hunger starts coming back. I've seen others add a little sema around then, about 0.5 mg, to keep the hunger down. Is that a sensible approach?
A 1 mg dose of Retatrutide counts as subtherapeutic.
You can combine the two since they actually complement each other. Reta is much weaker at GLP-1 than sema, which is likely why it doesn't control hunger as well, while tirz has a stronger reputation there. Reta stands out instead for its strong action on glucagon and GIP. Your current dose is also too low to help. Stacking isn't a bad idea, but try increasing reta first.
I add it three days after my reta shot, which is 4 mg every six days. I use just 0.1 mg and it handles hunger suppression well. Cagri didn't suit me so I keep using a low dose of sema instead.
That's the right response.
I run 4 mg reta with 7.5 mg tirz and have zero food noise. Your dose is way too low though. Some people get a full week of suppression from 2.5 mg tirz, but I've not seen anything about reta at your level lasting that long.
The idea is fine, but your reta dose isn't high enough to matter. Under 4 mg the glucagon part isn't working at all. Focus on reaching a useful dose with one medication before adding another.
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