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High heart rate on reta?

28 replies17 peopleOct 3, 2026☆ Follow
Summary

Does retatrutide cause elevated heart rate right after the first dose, especially if you already have anxiety?

Most users attribute the reported spikes in resting and activity heart rate to anxiety amplifying normal medication effects rather than a dangerous direct reaction at low starting doses. Several note that resting rates around 70 bpm and activity rates near 130 bpm are common with poor fitness or dehydration and often settle after weeks as the body adapts. A few people switched away from reta or added taurine when the increase persisted, while others saw no change or even a drop.

What this discussion establishesWhere people disagree

Whether someone with preexisting anxiety should start reta at all or switch to tirzepatide instead

Still open

How long any individual should wait before deciding the heart-rate change is tolerable or a reason to quit

Nothing here is advice.

28 replies · 17 people
SlowSignal13archiveopening postOct 3

A buddy asked me to post because his girlfriend is nervous. Her partner began at one milligram several days back, appetite is down and he feels okay. She started at half a milligram yesterday after already feeling tense from her anxiety condition. She got reflux, couldn't sleep from chest pressure, and now shows a resting pulse near seventy that climbs to one hundred thirty when moving around. She is scared and I saw no other posts matching this, so with her anxiety history I wonder if she should just stop. Still, did anyone else notice the same right after their first shot?

LevelThistle44archiveOct 3

The anxiety factor is probably masking whatever the medication itself is doing. Even if the symptoms are psychosomatic they still feel real.

SlowSignal13archiveOct 3
↳ replying to @LevelThistle44

That was my first thought too, and my other friends using it said the same. Still, it might calm her down to hear from more people here that she is not in danger and the drug is not directly causing it.

LevelThistle44archiveOct 3
↳ replying to @SlowSignal13

Everyone dies eventually, so accepting that fact lets you focus on living better. Whether she believes the medication will cause trouble or not, she will be right either way. Forty years old, one hundred eighty six pounds, twenty milligrams weekly. Just another Friday at work.

NorthKettle50archiveOct 3

Heart rate can climb for lots of reasons. Suggest she pick up a blood pressure cuff since they are cheap. Pulse alone does not give the full picture; low pressure can also raise it and worsen anxiety. Dehydration is frequent with this medication and can push the rate higher too. Chronic anxiety is probably the main driver here. One hundred thirty while doing light activity is elevated but depends on fitness. Tirzepatide might be the better option given her anxiety.

BrightSparrow36archiveOct 3

This medication does increase resting and exercise heart rate for some. Anxiety does the same. At forty six and female my resting rate rose by about ten beats, moving from low sixties to low seventies, then started dropping again around four months in.

PlainAlder11archiveOct 3

My own rate increased roughly eight beats per minute but returned to normal after thirty three weeks. Anxiety is likely playing a role too. Trial data show nausea in forty three percent, an average heart rate rise of about six point seven beats, and dysesthesia in twenty point nine percent at the twelve milligram dose. The increase is dose dependent, peaks near week twenty four, and trends back toward baseline later. The glucagon action is thought to be responsible.

CopperSignal27archiveOct 3

A resting rate of seventy is nothing to worry about. Rates during activity vary widely with fitness level. One hundred thirty while walking is higher than average and points to lower fitness but is not harmful by itself assuming no known heart issues and reasonable age. At only one milligram the whole episode could be anxiety rather than the medication. Because this drug raises heart rate more than other similar ones, any increase or noticeable beats can feed anxiety and push the rate higher still. If anxiety is already strong it may be simpler to try the alternative instead.

BrightCompass57archiveOct 3

Mine actually dropped. My wife saw no increase either; hers stayed about the same.

SteadyLantern35archiveOct 3

Mine reached ninety to one hundred ten at rest so I had to quit.

AmberCompass37archiveOct 3
↳ replying to @BrightSparrow36

Same experience here, heart rate rose eight to ten beats on this medication and I also had acid reflux early on.

IronBramble31archiveOct 3

Taurine bought over the counter can ease some of the heart rate increase. I use two grams daily while on three milligrams weekly. Reviews note an average drop of three point six beats per minute along with small reductions in both systolic and diastolic pressure, seen in healthy adults and heart failure patients alike.

SteadySparrow75archiveOct 3

I check my pressure and pulse multiple times a week and they have stayed the same since starting at the end of July, now at five milligrams. Anxiety about the known heart rate effect can itself drive the rate up even without much contribution from the drug at a half milligram dose.

LevelHarbour53archiveOct 3

Mine jumped over one hundred one morning along with a headache. After drinking an electrolyte mix, eating yogurt with twenty grams of protein and walking it settled. I had been worrying about combining medications so low pressure plus anxiety probably set it off. I skipped that dose and am now choosing between staying on the other option or trying this one.

SlowSignal13archiveOct 3

Thanks everyone for the replies; she felt better reading them. She is one hundred seventy two centimeters tall and weighs sixty nine kilograms, stays active with lots of biking so she is not unfit or carrying extra weight. She is feeling improved now and accepts some of it was likely in her head. She plans to monitor how she feels over the next few days before choosing whether to keep going or stop.

LevelThistle44archiveOct 3
↳ replying to @SlowSignal13

Why is the anxious, normal weight, bike riding woman at that height even using it?

PlainAlder11archiveOct 3

Anxiety really can raise heart rate on its own.

WrySignal35archiveOct 3

The first month I felt anxious about the faster rate but it eased after about thirty days once I ate some bread with chocolate spread. Not sure if it was adaptation or the carbs, but either way it helped. I also prefer morning injections over evening ones.

PlainAnchor66archiveOct 4
↳ replying to @WrySignal35

Bread and chocolate spread fixes everything, apparently.

SteadySparrow75archiveOct 4

Normally I'm uneasy around folks needing constant emotional upkeep... so it's strange I'm sharing a home with someone exactly like that... feelings just pull you in their direction I guess... still I understand the issue mentioned here more than feels comfortable to say... 😎

IronLantern24archiveOct 4

Anxiety is probably the cause. Not everyone gets a higher heart rate from reta. I never noticed any change myself.

SlowSignal13archiveOct 4

She has struggled to lose weight for years and carries hormonal fat around her stomach. After seeing my own results with reta she decided she wanted to try it too. She's an adult who looked into it herself, so I wasn't going to stop her. It might not be essential, but the other option was her doctor prescribing something else that would cost a lot more each month.

CopperSignal27archiveOct 4

Trying reta one more time could be reasonable, but if the anxiety keeps showing up even after discussing it and understanding the cause, switching to tirz makes sense. Especially since she isn't aiming to drop a large amount, maybe just five to ten kilos depending on her goal. At her current weight the BMI is already in a normal range, so further loss could go too far. Dealing with ongoing side effects is harder to justify when the goal isn't treating obesity.

BrightSparrow36archiveOct 4
↳ replying to @SlowSignal13

You passed over tirz, which is likely the better choice for her situation.

White coat syndrome hits me hard too, pushing my blood pressure up around 30 points. I still remember the childhood incident behind it. A wearable tracker is useful for separating real changes from that effect, especially if you already have a record of your normal numbers before starting anything new. I wore an OURA ring for six years until the battery gave out and switched to a RingCon instead, though plenty of other bands and rings do the same job now. Without a solid baseline for your resting heart rate when you're not paying attention, it's tough to know how much the new compound is actually moving it. I can watch my reading jump to 145/90 the moment I step into an exam room, but it sits at 110/68 the rest of the time when I'm just sitting at home watching TV or reading.

GreyFenwick31archive5d

Given her size she could certainly work on fitness and drop some weight without any of these compounds. Reta does raise heart rate and that seems to be part of how it helps. Tirz might suit her better. I've used both and noticed only a small heart rate bump with Reta that showed up later.

GreyFenwick31archive5d

She might be a good fit for one of the options aimed at belly fat. I believe it's called Tesa but someone else will probably confirm.

GreyFenwick31archive5d

But the top quality household pieces stand out to me.

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