Lost Tirz Effects After a Forced Three-Week Pause

At least this suggests that raising the dose slowly could restore the effects. Until yesterday I had only added a few units at a time because I was worried about going higher after the strong reactions I used to get. Thank you!

I get your point, but the pause was not a choice. A bad virus made me stop for three weeks. Before that I had used it steadily for six months and responded very strongly even at low doses. Most stories I have seen involve people who never had that strong a reaction at such low amounts, so the sudden total change surprised me. It might turn out not to be the right medication, but the break was forced, not casual.

This is really useful. Thank you for working out the numbers. I was comparing my current 3 mg to how 2.4 mg felt before the break without factoring in the months of buildup I had then. The figures make it clear that 3 mg now is not yet the same exposure I had at steady state earlier. Given my past strong reactions I agree about being cautious and will let this dose accumulate before raising further. Thank you again!

I know I never reached the standard starting dose; that was on purpose because I did not need it. Microdosing worked very well, got me to my goal, and now I only want to maintain without pushing higher than necessary for someone who responds this strongly. The wording in my post was deliberately dramatic and light. When I said terrified I did not mean an actual unhealthy mindset. Tirz worked extremely well for six months. My question was why the effects vanished after the forced break, since developing such quick tolerance seemed odd. The explanation about lost accumulation and the time needed to rebuild it fits best.

Thank you, that is kind! I agree I need to let it build back up. I also raise in very small steps because I really want to avoid the strong side effects returning. I have Reta on hand but have not tried it yet while I look into it more. My main concern is possible increase in appetite or food noise, especially now that I have reached my goal and mainly want to keep it. I am fully recovered from the virus now!

That is a good idea. Splitting the dose could reduce peaks while keeping the same total buildup. If side effects return as levels rise again, it could be a helpful approach. Thank you!

Wow, you reached your goal, congratulations! You do not have to worry then. Just go slowly and use the lowest dose that maintains the result. No need for bad side effects. Enjoy being at goal without feeling awful! That is great!

Thank you! Reaching goal is great, but I will not be able to keep it if Tirz no longer controls food noise. I am careful with diet and calories, yet binge episodes can erase days of work. That is why I am disappointed the effect has not returned. Still, the explanations shared here have given me a clearer picture, and I am confident I can find a path forward. Options I am weighing are raising the Tirz dose even though I am at goal, or looking more closely at adding Reta.

I am almost at six months and only halfway to my goal, moving much more slowly. I was on 5 mg Tirz plus 3 mg Reta, then switched to 4 mg Tirz plus 4.5 mg Reta. No appetite, though I did not have much before starting. Something just is not cooperating, and weight loss is still very slow while eating very little. I am not sure whether to raise again or adjust the mix. I still have about 26 lb left. Tirz helps my pain and inflammation more than anything, so I definitely do not want to drop it!

Yeah, I get that feeling too. Even with tiny portions my weight came off at a snail's pace and I hit multiple extended plateaus. Seems like our bodies just don't want to cooperate on this lol. You're already partway through though and reaching that 26 pound mark is definitely doable you'll make it. It can be annoying when things move slowly yet any movement forward counts and a steady pace tends to be gentler overall and simpler to keep going with. Plus since it eases your discomfort and swelling as well I see why stopping isn't appealing! 🫶

Exactly. Do not worry until you are using 18 or 20 mg and still want to eat a large meal.