Sudden side effects after 3 months of Mounjaro?

Did you start a new vial recently? Is this from a doctor or elsewhere, and are you sure the dose was right? I ask because it sounds like you might have more medication in your system than usual, similar to what many people feel in week one.

If there’s actual pain then yes, see the doctor. What you describe sounds like ordinary GI issues that can appear out of nowhere. Try daily omeprazole for a week and see if it improves.

I’ve been on 5 mg for a few weeks already. It’s a real Mounjaro pen from my doctor.

Even on the same dose the medication can build up and cause GI sides that come and go. I get painfully bloated sometimes but it passes before the next meal. My usual remedies are a PPI for heartburn, Pepto for several stomach issues, Alka-Seltzer for indigestion, simethicone for bloating and pressure, or ondansetron if nausea is bad. I just skip the next dose until things settle.

I’m also on 5 mg. Some days I feel nothing, other days I’m full all day and burping constantly.

I still have plenty of pantoprazole left, so I’ll try that.

It’s not really pain, more like discomfort, constant burping that sometimes brings up a little liquid, and a pressure feeling.

Is the feeling there the whole week or only right after the injection?

If the doctor is worried they might order an abdominal ultrasound.

It started only in the last few days. Injection day is Sunday but the symptoms were already present before today’s shot. I did drink alcohol on Friday and overate quite a bit for the first time in months, plus our child was sick and vomiting on Thursday, though the symptoms seemed to begin before that.

To be safe you could ask for pancreatic markers like lipase and amylase, cholestasis markers like GGT, ALP and direct bilirubin, plus an abdominal ultrasound.

My GGT was 26 (lab limit under 64), ALP 31 (limit under 50), direct bilirubin 0.52 and indirect 0.93. Bilirubin has always run high for me, even as a child, and the doctor wasn’t concerned.

I’m still on the real prescribed pens, but today was my first grey version. The sides started before that shot. It came from a well-known source that had testing done for purity and was filtered.

Even with testing, one vial from a large batch doesn’t guarantee every vial is the same strength. That could explain stronger sides at first. Differences in the active ingredient quality between the brand and other sources might also play a role early on.

The sides were already building for several days before today’s shot, so the timing was just coincidence.

Splitting the weekly dose into two smaller injections can reduce sides for some people. I’ve noticed the sides return when I go back to a single weekly shot, so I’m planning to split again until I’m on a lower dose.