Mazdutide 48-week study at doses up to 16 mg and user experiences

Reta works for many but causes issues for others, just like semaglutide and tirzepatide have for some. I am currently using mazdutide myself, though it is still too early for me to say how it is going.

Appreciate the information. Keep us updated on how the mazdutide goes. What dose are you using at the moment?

My schedule is more involved than most would want. I track daily levels with a spreadsheet that estimates how much remains in the system. The right column shows the amount present; the left shows the daily injection. I round off the hundredths and aim to increase the level by 0.2 each day. The calculator assumes a 10-day half-life. Bold numbers are future planned doses.

Are you running mazdutide by itself? Most reports involve stacking it with survodutide, so there is not much solo feedback yet. I would be interested to hear how it goes if you are not combining them.

Why inject every day? That sounds very precise.

I also take tirzepatide at 1.1 mg daily. I stay at that level because higher amounts leave me fatigued and cause stomach issues.

These drugs were never studied with daily dosing, which is one reason not to use the newer ones that way. I dose daily so my system can adjust gradually and to avoid big swings in levels. Weekly schedules mainly exist because most people prefer fewer injections. Whether daily use actually lowers side effects would need proper trials.

No side effects at all? That is excellent.

Tirzepatide gave me sulfur burps, loose stools, and early sleep trouble, though nothing severe. I also get the vivid, sometimes unsettling dreams that some people report with retatrutide.

One day someone will share results from mazdutide used alone.

Matching retatrutide-level results with mazdutide seems to require 10-16 mg doses according to the available studies. Those trials did not test the two drugs head-to-head, but a recent 48-week study used 10 mg and 16 mg of mazdutide.

I am not sure which study you mean. The 6 mg arm looked strong through 24 weeks. Losses usually slow after that, so extending the lines may not be accurate. Do you think mazdutide affects the liver differently?

Any weight-loss drug tends to lower liver fat, but those that also activate glucagon receptors do so more strongly. Mazdutide and survodutide are partial glucagon agonists, as is retatrutide. I have not looked into glutathione.

I thought you had higher ALT readings and switched because of that. Maybe I am mixing things up.

ALT reached ten times the upper limit. I waited for a hepatologist before considering any liver support. We stopped both retatrutide and Lipitor at once even though neither of us thought retatrutide was the main cause. Levels later fell to twice the upper limit. A Fibroscan showed no fatty liver. I may restart retatrutide later.

Good to hear the numbers are improving.