Higher dose for higher weight

I get nervous about the idea of burning out receptors and losing the effect later, but I'm already not feeling much so my body seems to be saying go up. Still dropping a tiny bit from exercise and forcing a deficit, but it's a struggle. I'll increase and see if that helps.

Nutrition is already locked down. Lower carb, whole foods, no liquid calories, right around seventeen hundred a day when maintenance is twenty-three hundred, and plenty of lean protein. Still losing a little but holding the deficit is tough. The Tirz seems to wear off after a couple days and then the food noise and hunger come roaring back.

Haven't seen any solid reports of people blowing out receptors even at twenty-plus milligrams a week or when stacking with Sema for extra GLP exposure. I started splitting my dose in week three on Tirz, carried that over when I switched to Reta, and the return of food noise on days four or five is exactly why I split.

Big lady, thank you very much.

I tried splitting but actually got better suppression spacing it every five or six days instead of every three. Hoping the added Reta will help more.

Big un is funny. Can't help it, I'm like a dog, totally food motivated.

Heard a doctor on a podcast say once-weekly is better because it lets the body clear some peptide and resensitize receptors, which could let you stay on lower doses longer. Can't recall which doctor but it sounded logical. Have you noticed any difference between weekly and every three or four days?

Food noise was my main issue, rarely true hunger but always ready to eat. My goal is to lose about a third of my starting weight on GLP or close to forty percent of my highest weight from 2018. Only twenty-four percent of people on twelve milligrams weekly Reta hit thirty-five percent or more loss, so I'm at sixteen milligrams a week to improve the odds.

I've heard the same advice. Not sure if it's true, doesn't sound right to me. Never gone more than five days without dosing because the hunger gets too strong. I love eating. The other day I took my two milligrams early to try to skip some brownies I made and still ended up sick and ate a huge one plus more later. Probably need Cagri.

The idea of GLP-1s causing receptor desensitization is a misconception at normal doses. They work systemically and don't target one narrow set of receptors the way some peptides do, so titrate up slowly until it starts working again.

Yeah, that sounds like Instagram influencers mixing up Reta cycles with testosterone cycles. Those people are already lean and chasing shredded looks. Most of us just want a healthy weight and the studies used longer continuous time frames, not cycling.

Glucagon receptor activity looks dose dependent. My approach has been to push Reta up as fast as sides allow, otherwise it's basically just Tirz without the extra benefit. That assumes the goal is dropping a lot of weight.

Completely agree. I'm no doctor, just another poster, but it feels like the Reta at that dose is doing almost nothing.

Married with Children, Al Bundy reference, except he was talking about big TaTas.

Don't know enough about your situation to give advice, but seventeen hundred calories would be too high for me to lose much regardless of food quality. I've been aiming for twelve hundred with high protein and haven't stalled. Food noise is basically gone for me on five milligrams Tirz so some days I don't even hit twelve hundred. Added one milligram Reta mid-week to move toward Reta for maintenance and drop Tirz to a micro dose. Sixty-five pounds down, sixty-one-year-old female, on Tirz since December first.

I weigh two-sixty so twelve hundred would be way too low. Don't want to lose muscle. That would be over a thousand-calorie deficit for me. Congrats on the loss though.

I trust that least of all. Hard scientific evidence put me in the hospital for a week after the second Pfizer shot. No thanks. I'll stick with circumstantial anecdotes from overconfident forum users.

Sleep matters too. Getting enough is important.

One hundred percent right on that.

Sorry to hear you ended up in the hospital. Hope you're good now. The shot worked fine for me. I like science because it separates emotions and anecdotes from actual statistics. It's not perfect but it's the best we have, and it teaches me never to be overconfident.

Don't hear much about Cagri around here.

New here, but what does food noise actually mean? I've seen it mentioned a few times.

I think it means the background hunger or cravings that show up between meals when you don't want to be thinking about food.

I see that too. For me dosing every five days feels ideal. Though this one has a bit longer half-life so it might build up to a higher steady level. But that's nothing major. Studies begin participants at two milligrams. I dose it every five days together with my other one and figure I'll shift to every six days when it starts replacing the other more.

Okay that makes sense. I had a lot of that in the first three or four months on Tirz but it's pretty much gone now.