Considering raising Reta to 20mg after long stall

I cannot answer your question since I'm on a low dose. But have you considered calguritide or maz in your stack? Those hit a different receptor.

Not my own experience but I've seen reports of quite a few people breaking a stall with elora. I'd try that or cag before going up to 20 mg of reta.

My initial belief was that the two compounds engaged matching receptor sites, though the first one felt far easier to handle overall.

When I elevated the level too far my rodent saw its glucose reading fall. Now I'm pondering those two substances.

For some time I thought about cagri yet the exhaustion it brings was something I wanted to avoid completely. I planned to add tirz to my reta but later shifted my plans. About ten days ago I began elora at a small amount of half a milligram. Sema counted as another possibility too.

If the original poster plans to reach twenty milligrams of reta, I'd really like to hear the input from someone who has already gone there. Very few have attempted such a large amount with reta, but this individual did and survived to recount it.
👍 👍 😎

Back in August when I reached 200 pounds I lowered my weekly amount from 20 mg down to 8 mg and appetite stayed under control. I raised it again to finish the remaining weight. My sleep now feels at least as solid as right after that reduction and noticeably better than it was in September. Bowel movements have been more consistently comfortable than I can remember in quite a while. There could be longer-term questions at these amounts but nothing has appeared for me and no studies indicate problems. Older work suggested reta might allow the most headroom on dosing before issues arise, though that came before phase 3 results. Bloodwork will reveal whether anything stands out. A couple more months and I’ll repeat the micronutrient panel and fatty acid balance test. A few values were low or borderline earlier and the balance test looked off, which pointed to fish oil even though I had already stopped taking it months before.

This sits a single milligram off what proved fatal for the other fellow.

Before moving into untested higher amounts, have you tried adding extra exercise for one week or cutting another 100 to 200 calories daily for a week? Those steps have helped me move past plateaus. Biology also shifts once you reach the final 20 pounds. What worked earlier can stop working. Hunger becomes tougher to manage at both conscious and subconscious levels. This can look like a long stall. If you are not carefully watching intake you might be adding calories without noticing and that can create the stall.

You have already lost 43 percent of your starting weight, so well done. Almost no real research exists yet on how to handle losing more than 30 percent. Next steps would probably depend on current side effects. You have not mentioned any problems, so going higher with reta makes sense if nothing is bothering you. Just to be cautious it might be worth checking that heart rate is not elevated, since high-dose data is still missing. Elora could be the stronger addition because it works on different receptors and appeared to give extra loss even on top of 15 mg tirz, around another 12 percent. Higher reta amounts are more likely to hit diminishing returns. Cagri did not add as much extra loss when paired with semaglutide. It is a long process and you may need to test several approaches.

Many unknowns remain around these situations and the biggest one for me right now concerns how much time this particular pause has already taken up. Anything shorter than roughly a month and a half sometimes clears without extra effort yet that does not lessen the worry when earlier pauses have already happened. Food choices and movement still matter a great deal even while these medicines are in use and simply raising the subject tends to annoy folks who feel they already tried both without results. Still the medicines appear to fix an important feedback loop that influences how the body handles energy and resists insulin a problem that pushes fat storage while stopping the release of stored fat for fuel. In the past I have checked my own intake numbers and stepped up activity for a short period as a way to test whether the medicines now allow those steps to produce movement where nothing happened before. It would be good if the original poster could meet with a doctor focused on metabolic issues and if possible get full blood work plus a body composition scan since that scan shows exactly where fat sits and whether the pattern calls for one approach or another. I also track my own readings with a multi electrode home scale even though it is not exact because daily fluid changes can swing the numbers wildly so I only watch the pattern across weeks instead of any single reading. The extra suggestions about recalculating daily burn rates checking protein while lifting and looking at sleep and stress levels also line up with what I have noticed in my own case.