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Retatrutide weight loss stall after major progress with peptides and low hormones

74 replies22 peopleFeb 19, 2026☆ Follow
Summary

Why weight loss has stalled on retatrutide despite a claimed deficit and what changes to make next

The thread centers on persistent plateaus after substantial loss, with the original poster noting low E2 cortisol and DHEA alongside recent IPA/TESA use and a batch change. Participants recommend tighter tracking methods, DEXA scans, and adding or switching to other compounds for stronger suppression while pausing secretagogues because of possible ghrelin-driven retention. Shared experiences highlight water weight from TRT creatine and peptides plus variable hormone levels and hesitation around permanent TRT. The discussion debates whether intake is truly low enough or if overlooked factors like oils and trim explain the stall.

What this discussion establishesWhere people disagree

Whether calories are actually low enough and whether metabolism has genuinely slowed versus tracking omissions

Still open

Whether a new retatrutide batch will resolve the stall or if deeper adjustments to intake and compounds are required

Nothing here is advice.

74 replies · 22 people · page 1 of 2
RustWillow38archiveopening postFeb 19

Trying one more time to understand why RETA effects have stalled. I'm 50, 6'2", now 282 lbs after starting at 314 in August and beginning RETA on Oct 4 at 308. Background includes rugby, wrestling and other land-based sports, with injuries reducing activity but not making me sedentary. My body feels fast and fit in the 235-255 range. RETA worked well from Oct starting at 0.5 mg up to mid-December at 5 mg, getting me to 282 with little effort. Since then progress has flatlined at 12 mg. Typical diet is 6 eggs to start the day with a couple coffees using coconut sweetener around 700 calories, lunch protein shake with 2 scoops for 60 g protein at 240 calories, some beef jerky at 200 calories, and a meat-based dinner around 1000 calories, totaling about 2200 low-carb calories. Blood work twice showed low estradiol, low cortisol, low DHEA, and low B12. I've been supplementing extra B12, adrenal cortex, and DHEA for 3 months. Everything else looks solid. What changed includes a new RETA source and a two-week pause around Christmas that added 9 lbs, plus starting IPA and TESSA while titrating RETA further.

SharpFenwick93archiveFeb 19

You're taking in too many calories overall. It's not really a fat burner the way some imagine, though it does increase fat oxidation. At 12 mg, is your hunger still strong? If it is, you could add some cagrilintide. Before that, try a week cutting calories to around 1800 and see how it goes.

RustHarbour10archiveFeb 19

Was the RETA from the new source properly tested? That would rule out an easy issue. I also agree with lowering the calorie count.

RustWillow38archiveFeb 19

Some hunger but nothing overwhelming.

LevelThistle44archiveFeb 19

How much water retention from the TESSA? How much exercise? Are you really tracking intake? It's just math at the end. Two pounds of fat loss a week needs about a 1000 calorie daily deficit. I was 282 lb on 12-12-25. 2200 is my soft daily limit. Usually well below so the occasional higher day doesn't matter. Average recorded around 1700 but expect error especially eating out. Average 800 calories of activity daily but expect error there too. Daily goal is 500 calories of exercise, usually treadmill for easy calculation. Started TRT in January and gained 3 lb overnight three weeks later, took a week to drop back, still expect to be carrying 2-3 lb of water that should come off next month.

ClearHarbour45archiveFeb 19

I suspect weight loss involves more than just counting calories, particularly when someone weighs around 280. Perhaps the evening meal comes too late in the day, such as after seven. I find drinking plenty of water helps too. Every six days I combine a small amount of one medication with my usual dose of another, though I believe that mainly reduces appetite. I alternate between two different medications on a six-month cycle.

WarmHarbour28archiveFeb 19

At sixty years old and standing six foot two, my weight dropped from three hundred thirty pounds down to two hundred seventy. There was a plateau lasting over three months around two hundred eighty five that really annoyed me. It was tough to deal with. People suggested skipping meals, yet that caused shaking or made it stronger. Instead I reduced my portions while slowly adjusting the dose. Even one egg was too much and made me throw up, same with anything over a quarter pound burger. The other day both meals were fish and it left me hurting badly. My spouse keeps serving too much food. I skip workouts but handle household tasks.

RustWillow38archiveFeb 19
↳ replying to @ClearHarbour45

That was my thought too. I try to eat between 4:30 and 6, keeping that in mind because TESSA is fasted at night. Really curious about switching and any benefit of TIRZ over RETA plus the other add-ons like sema and cagri since I haven't tried them. Trying to lose body fat and reach 240-250 seems like the goal.

QuietTimber26archiveFeb 19

I've noticed that insulin resistance tied to IGF-1 follows a U-shaped pattern where either high or low amounts can trigger it and halt progress on shedding pounds or even cause gains back. Anyone curious about growth hormone releasers should look into how IGF-1 and GH interact. I paused my use of the secretagogues, waited thirty days for clearance, measured my baseline IGF-1, started them again, and tested levels once more. I also wondered whether the mix contained both in one. The second component reaches full effect near that microgram range, yet most combined products include excessive amounts of it.

RustWillow38archiveFeb 19
↳ replying to @WarmHarbour28

nice seeing your headway so far ... thinking i might give fasting a try over five days just to switch my routine around

RustWillow38archiveFeb 19
↳ replying to @QuietTimber26

Hearing this is quite pleasing... It looks like an external process is stopping my weight reduction in ways I can't figure out yet... Things were going well for me earlier, and my meals stayed pretty much the same. I should check into this process more.

RustWillow38archiveFeb 19
↳ replying to @RustWillow38

They're separate, not combined. The first one at two milligrams on an empty stomach before sleep, cycling five days active and two rest. The other at two hundred fifty micrograms in the morning and again at night under the same cycle. Approaching the eighth week soon, yet I'll take a break for four weeks to measure my baseline igf-1. Grateful, fingers crossed this does the trick.

PlainAlder11archiveFeb 19

I find it tough to manage six eggs while using Reta. Instead I might have one hard boiled egg along with two sausages. We divide those every other day and occasionally add more via a shake made from protein powder scoop delivering twenty four grams, oat bran and collagen. For lunch perhaps a single burger patty with some steamed broccoli that we share. Ten wings get split once weekly. Evenings usually involve meat such as pork chicken beef or fish on one day. Our meals moved earlier from six thirty down to five or five thirty. This schedule suits us and appears beneficial. I never carried much extra but peaked at two hundred fifteen pounds and reached one hundred ninety nine with one hundred seventy five as target. Right now at four milligrams and plan to inject the next dose tomorrow morning. Six weeks on this so far.

RustWillow38archiveFeb 19
↳ replying to @PlainAlder11

It looks like the lack of appetite for meals disappeared around the holidays while taking five milligrams. Now that I've gone up to the top level of twelve milligrams, the thoughts about eating haven't quieted down nearly as much as before.

BlueAlder12archiveFeb 19
↳ replying to @SharpFenwick93

I don't know. 2000 kcals for a 280 lb male isn't really reaching maintenance even for a sedentary one, more like 2600 to 3000 a day.

PlainAlder11archiveFeb 20
↳ replying to @RustWillow38

Cravings for food aren't bothering me anymore, which seems strange. By evening I'd usually be looking around for desserts and end up grabbing frozen treats from the fridge. There are still a couple of containers sitting there untouched. And then there's the holiday sweets scattered around the place. My spouse would try to conceal them but I always managed to locate the stash. 😊

LevelThistle44archiveFeb 20
↳ replying to @BlueAlder12

Having been that size, 2600 cal I could agree with. Without quantifying calories in and out it's all relatively pointless to speculate. It's not just that simple but also not rocket science with mysterious variables. DEXA scans are good for quantifying composition baseline and changes.

IronHarbour69archiveFeb 20

I'm curious how your male hormone, thyroid, blood sugar fasting and hemoglobin A1C are doing. With reduced estrogen, your male hormone ought to be reduced too from the conversion process rising alongside extra weight. Did you look at bad cholesterol and that Lp(a) marker? Bringing in more elements prior to clarifying the situation just adds layers of difficulty. Changing providers for the weight loss drug seems questionable too, what steps will you take to address it? Dried meat contains high salt that leads to fluid buildup. How many daily walks do you log? I suspect you might not be counting all your food energy accurately. Running a second tracker could reveal any gaps in your current log.

KeenAlder60archiveFeb 20
↳ replying to @PlainAlder11

It's nice knowing others also lack appetite while on this medication. Nighttime desires for sugary treats persist yet rather than frozen dairy I opt for an apple pear or some small sweets in fruit tastes from Germany that measure tinier than a coin half. Regarding the original poster's experience I encountered a comparable pause in progress after dropping about eighty pounds. That plateau lasted quite some time until progress resumed. At present I'm combining Reta at four milligrams with Tirz at the same dose and sit just short of my initial target. I'm considering establishing another target since I never anticipated hitting this mark.

PlainAlder11archiveFeb 20
↳ replying to @IronHarbour69

Want to hear a funny story? About a fortnight back I visited my doctor to check on some lab results. All the numbers looked fine except the salt level came in a bit under where it should be. So I asked what that meant and he told me to add a pinch of salt to my food without going overboard since it could push up my blood pressure.

BlueAlder12archiveFeb 20
↳ replying to @RustWillow38 (opening post)

Got any hens? That works out to about three and a half dozen each week. I think there could be space for it inside the cooler. Nope, no hens here.

PlainAlder11archiveFeb 20
↳ replying to @KeenAlder60

Losing eighty pounds sounds fantastic. How long did that take, if you're okay sharing? Otherwise, it's fine. Truthfully, I have no appetite once evening comes.

IronHarbour69archiveFeb 20
↳ replying to @PlainAlder11

It's a rapid straightforward approach because experts advise those suffering from low blood pressure to raise their salt consumption and avoid fainting along with head injuries from falling.

KeenAlder60archiveFeb 20
↳ replying to @PlainAlder11

I'm a slow responder so it's been over a year. I'm not sure but thinking it was over about 18 months.

PlainAlder11archiveFeb 20
↳ replying to @KeenAlder60

The waiting period has zero impact since the end result feels excellent anyway.

KeenAlder60archiveFeb 20
↳ replying to @PlainAlder11

No complaints here at all. I've shed a hundred pounds so far and sit twenty short of my original target. Considering an even smaller target now strikes me as pretty astonishing.

RustWillow38archiveFeb 20
↳ replying to @PlainAlder11

A few orders later and this stuff always leaves me feeling awful the next day. My meals have stayed quite wholesome lately yet thoughts about eating seem stronger than they did at the beginning.

RustWillow38archiveFeb 20
↳ replying to @LevelThistle44

Although I lack experience with DEXA scans, my food intake hovers around 1800-2200 calories daily without doubt.

RustWillow38archiveFeb 20
↳ replying to @KeenAlder60

Like to hear more about why stacking TIRZ with RETA makes the difference. Doesn't RETA have similar mechanism already?

BlueThistle33archiveFeb 20

When progress halts or you hit a wall, I figure there are basically just a pair of choices... Either increase the aerobic sessions or reduce food intake. What's the level of effort in your aerobic work like? Maybe include certain compounds or classic reduction mixes ahead of those sessions to heighten the burn, though it hinges on how you tolerate such substances... One item causes fluid retention, so after stopping it you might look less full yet the numbers could drop a bit once you discontinue.

RustWillow38archiveFeb 20
↳ replying to @IronHarbour69

I had testosterone checked three separate times over recent months while fasting in the morning each time. The numbers came back 503 then 382 then 550. Thyroid markers all sat in range with T3 at three, T4 at point nine and TSH near three point nine. Fasting insulin registered five point three and A1c sat at five point two. Only the lipids looked slightly off with LDL at one forty nine, total cholesterol two hundred seven, triglycerides ninety four, HDL forty one, VLDL nineteen and the ratio at five. My partner tried the same compound and reports it performs well for her. I am also pausing the two peptides for thirty days to establish a starting IGF-1 level. The rest of the panel showed estradiol under fifteen, morning cortisol at seven point four, B12 at two fifteen on the lower side and DHEA at one thirty seven. I had skipped labs for years but figured it made sense while chasing body recomposition. I carry plenty of muscle and hit two hundred sixty five pounds of solid weight during double training sessions without ever using any substances.

WryFenwick10archiveFeb 20
↳ replying to @RustWillow38

What method are you using to log your daily energy intake? Plenty of folks misjudge the amounts they actually eat. I've learned that lesson firsthand.

IronHarbour69archiveFeb 20
↳ replying to @RustWillow38

It's surprising how aware you are that estradiol helps guys out, since plenty try keeping theirs super minimal and end up worse off. I suspect elevated SHBG paired with reduced unbound testosterone accounts for the minimal estradiol levels. Did you check those other blood markers? Current recommendations suggest keeping LDL under 100 except when facing additional problems. Recently I got a bone density test and it turned out way more useful than expected.

RustWillow38archiveFeb 20
↳ replying to @WryFenwick10

Every day my morning meal stays identical along with the drinks and my midday shake. It is always five eggs with a bit of cheese for four hundred calories in all. The pair of coffees mixed with coconut powder comes to one hundred eighty calories. The shake adds two hundred forty. Dinner follows after.

BlueTimber78archiveFeb 20

If your intake hasn't changed, that explains the halt. As body mass decreases, the energy needs drop accordingly, so the same amount now maintains weight. I followed a similar path by holding my food consumption steady over several months. Eventually the scale stopped moving downward. Adding compounds known for causing fluid buildup didn't help matters after they stabilized. Even with higher amounts of the medication, identical eating habits, and increased physical activity, there's been no further drop. That's fine though because I'm moving toward a stable point. Your situation matches what happened to me.

RustWillow38archiveFeb 20
↳ replying to @BlueTimber78

I'm aware that cutting intake happens with dropping pounds yet I figure a shortfall should remain anyway. On top of that progress didn't ease off gradually it just halted abruptly like slamming the brakes which feels odd. Following some suggestions I'm going to pause those aids for thirty days then check my growth factors and switch to a stricter intake cut. Maybe skipping meals entirely for a stretch to break the pattern. What combines with this med to manage cravings? I've noticed mentions of several alternatives or whatever. Need to alter the approach now.

BlueTimber78archiveFeb 20
↳ replying to @RustWillow38

My progress halted suddenly too and I added five pounds over four days. Intake stayed steady while exercise increased along with a small bump in reta but I had just begun creatine plus cjc/ipa. Water retention on that scale had never shown up for me before though at thirty pounds heavier I tracked nothing so it might have slipped by unnoticed. This lines up with my own reta experience so far since we both began around October. I fell from two twenty down to one seventy one at the lowest point then rose to one seventy seven and now sit at one seventy three. The scale quit moving the moment training and creatine both went up. I remain on the same batch from October without switching. Really curious what my numbers do after I drop the ghrp items.

WarmHarbour28archiveFeb 20

I can't seem to locate that particular saying anymore, but it pointed out that one pound amounts to a bigger share once your body mass has decreased. That idea showed me the reason my progress has been dragging as I slim down. After that, I kind of stopped bothering with the whole thing and quit paying attention to measurements. Then one morning I noticed I looked rather skinny, so I got on the scale and discovered a four-pound drop. This stuff is hard, but I'm right there with you.

RustWillow38archiveFeb 20
↳ replying to @BlueTimber78

I don't intend to hope others fail to move forward but it's reassuring to learn another person went through something comparable. The daily energy total doesn't strike me as the main obstacle though I could easily be mistaken. Eating near two thousand ought to allow at least gradual reduction even after the rate dropped for eight weeks before halting altogether. The final dose happened on the seventeenth of February. I'll look at the markers again around the middle of March once the advised waiting period has passed including growth factor one and a few other unusual results from earlier. That should show whether my strict routine produced any shift. It feels as if the body's burning mechanism has turned off altogether.

GreyCompass75archiveFeb 20

I'd book a DEXA scan for some solid baselines. You likely dropped a bunch of water and glycogen early on, so the scale alone won't show the full picture of what you're dealing with.

QuietFenwick11archiveFeb 20

Drop the ipamorelin since it's a ghrelin agonist and works against the reta. I'd also pause the tesamorelin unless you have a smart scale to track the extra water it's causing.

ClearHarbour45archiveFeb 20
↳ replying to @QuietFenwick11

I'm finishing two weeks on tesa at 2 mg Monday through Friday. First week I gained three pounds and I'll check the scale tomorrow to see where things stand. The same thing happens when you add test or hgh. With test I put on about ten pounds the first month then started dropping it around month three.

LevelThistle44archiveFeb 20
↳ replying to @ClearHarbour45

I gained three pounds overnight fifteen days after starting TRT. It took nine days to hit a new low. I got an Oura Ring on day eleven of TRT and it didn't fit five days later. Sixteen days after the jump it still doesn't fit that finger but I'm four pounds lighter than before the jump. I'm hoping that three pounds comes off in the next month or two. I'd be happy if it turned out to be a sneaky ten pounds of water weight.

RustWillow38archiveFeb 20
↳ replying to @BlueThistle33

I do some machine cardio for half an hour five days each week but nothing too intense. My aim is to reduce swelling and shed extra pounds so old aches don't flare up again. That's why I keep things easy on the body while waiting for these special compounds to sort it all out. I make sure to drink plenty of water and hit one hundred fifty grams of protein even though that part isn't easy. My rest routine is consistent now thanks in part to glycine along with other aids. Every day I use ghk-cu and recently added bp 157 with tb 500. Might need an extra boost so I'll give something else a shot.

RustWillow38archiveFeb 20
↳ replying to @WryFenwick10

I stick to this routine for protein every day up until midday. I eat five eggs first which gives me thirty grams of protein and three hundred calories. Then prior to noon I mix a protein drink using two scoops blended with sixteen ounces of water and ice cubes adding sixty grams of protein and two hundred forty calories. Later in the afternoon I have another identical shake for the same amounts. Around four thirty to five thirty in the evening I eat a meal centered on meat aiming for over twenty grams of protein. This brings my daily total to one hundred seventy grams of protein and sixteen hundred calories though it might reach two thousand if I indulge a bit. Should I crave something different I go ahead and eat it yet I end up satisfied anyway. I also consume glycine sometime during the night.

ClearHarbour45archiveFeb 20
↳ replying to @LevelThistle44

I expect those added pounds will fall off later on. Toward the middle of May I'm starting a run with the two compounds at 250 each and I'm sure the scale will climb by fifteen pounds before it drops again afterward. Someone criticized me claiming bad eating habits caused the increase while on tren yet the testosterone is what actually drives it. My normal replacement amount sits at one hundred twenty milligrams so going well past double that brings the weight along.

RustWillow38archiveFeb 20
↳ replying to @ClearHarbour45

Soon I could start testosterone replacement therapy. The notion of lifelong dependence really puts me off though.

ClearHarbour45archiveFeb 20
↳ replying to @RustWillow38

Twice I went through that whole thing lasting twelve to eighteen months each time then stayed away for about a year afterward. It wasn't the smartest move but I still got everything back to normal in my fifties. After three weeks without the testosterone I began fifty milligrams daily of that medication for six weeks and brought my readings up near four hundred fifty.

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