Wegovy vs Reta

It's completely your choice. I moved from Tirz to Reta because of the fatty-liver results the trials were showing. If you can afford it, give it a try after you do your own research. You could also fill the Wegovy prescription and keep it for maintenance later.

I haven’t used Wegovy but Reta took me out of the pre-diabetic range. Bloodwork two weeks ago showed my A1c is now in the healthy range. If you can get Reta I would choose it over Wegovy because it’s a triple agonist instead of a single one.

If your insurance price for Wegovy is low, there are benefits to using the regulated version instead of grey-market Reta, mainly no chance of contaminated or mislabeled product and no need to mislead doctors. Still, semaglutide has the worst side effects and smallest weight-loss effect of the GLP drugs and is probably not as effective for fatty liver, though the data on Reta are newer. I had a year of nausea and malaise on semaglutide before switching. For me, Tirz 15 mg plus Reta 5 mg weekly produces fewer side effects than 0.8 mg weekly of Ozempic. One plan is to start Wegovy, monitor side effects and NAFLD response, then switch if needed.

I added 1 mg of sema to Tirz for about ten weeks last fall and had zero side effects. Results vary. I wouldn’t switch fully to sema because it’s weaker than Reta or Tirz, but if insurance covers it cheaply I would still fill the prescription and either save it for maintenance or use it as a stack later. Other options like selling or giving it away exist but are probably illegal.

I would use Wegovy without hesitation but I would check the copay first. Mine is over seven hundred a month. Wegovy does have clinical trials supporting its use for fatty liver.

My insurance covers the treatment fully. I’m thinking of asking my doctor to switch the prescription to Mounjaro because Tirz is a second-generation drug and supposedly better than Wegovy.

If the choice is between prescription Tirzepatide and grey-market Reta, Tirzepatide is probably better even if Reta is slightly stronger, mainly because you avoid extra side-effect risks from an unregulated product.

I wouldn’t use Wegovy even if it were free. It has the worst side effects compared with Tirz or Reta.

Wegovy belongs in the bin.

Reta worked for me. Labs that were in the danger zone moved solidly into the normal range for liver, kidneys, blood glucose, and A1c. In five months it reversed years of decline. My creatinine dropped from 1.7 to 0.98, something I don’t think is possible any other way.