How was your fatigue with Cagri?

Reta was my first. I'm 5'6 and currently 160lb after starting from 190. Lost 10lb on it but stayed hungry the whole time. Maybe I'm just not very responsive.

What stops you from going higher?

I'm open to raising it. Just weighing that against trying CagriSema, since some report stronger appetite control with it. Maybe I'm overthinking and should simply increase the Reta.

Cagri might help shift the body's weight set point in a way the GLP-1s don't, which is another reason I'm looking at related compounds. CagriSema looks promising overall.

Hunger control isn't a problem for me once the dose is higher. I switched from Tirz to Reta and only added a couple Tirz doses when food noise returned, but otherwise haven't struggled with overeating.

Really? I hadn't come across that idea and would like to read more. Any sources you can point to? I knew Reta can raise metabolism but not this angle with Cagri. Edit: Thanks

Look it up on academic search engines.

In theory maybe, but even with complete hunger elimination I still hit a weight floor after eight weeks no matter what I ate. I did four weeks at 0.25mg then four at 0.5mg and am due for 1mg. Also taking 7mg Reta twice weekly. No sides at all, though I'm near the end of my journey and only five pounds from goal. Hunger control works but long-term set-point shift hasn't shown up yet.

Increasing the current dose makes the most sense right now since you still have room to go up. Reta's hunger effects seem to strengthen at higher amounts according to available data. If sides stay manageable, just titrate. Also unsure if your CagriSema is pre-mixed; I'd rather add Cagri or Sema separately. I started adding Cagri to Tirz last week after already exceeding the usual Tirz maximum.

Interesting point. It also leads into discussion of a more selective amylin agonist that shows nearly double the weight-loss effect. Cagri may be less clean because it also activates calcitonin receptors, which could explain why some feel sick rather than simply having appetite reset. We may eventually learn what happens after stopping through proper discontinuation studies, and stopping Reta might produce an even larger rebound.

Don't pass up the chance to overthink. What about combining Tirz with Reta, or layering Sema and another med, or even adding a trip abroad? Or mixing intermittent fasting with yet another peptide?

The vacation idea sounds good.

How has the Cagri been treating you so far? I also get dry mouth with it.

Really enjoying it. Food noise dropped to nothing, similar to the early Tirz period. Almost no interest in eating, yet sides have been absent and I can still get meals in when needed.

Then how would I finish the supply I already have?

The drop in hunger from Cagri is striking, very much like early Tirz. Dosing is touchy though; a little extra and nausea appears, but the right amount feels excellent.

Completely agree. Cagri has been a stronger addition for me than the Sema I tried last year. The total absence of hunger is different from the food-noise quieting that Tirz and Sema provide. I've had no hunger cues since starting yet can still eat to meet macros. Keeping the dose low and slow because it feels potent.

I figured I'd stop Cagri but don't want to. Staying on all three for now, just spacing the injections further apart.