Half-lives / Cagrilintide

Cagrilintide half-life

Cagrilintide stays in your system about 37.5 days — five half-lives at a half-life of ≈ 7–8 days (180 h). The computed decay curve is below, with the primary source cited.

Also searched as: cagri.

50% · 8d030d (≈5 half-lives)
Single-dose relative level over time, computed from the published Cagrilintide half-life (180 h). An estimate from population values — individual pharmacokinetics vary.
Half-life
≈ 7–8 days
Class
GLP-1 & incretin agonists
Route
SubQ · weekly
~97% cleared
≈ 37.5 days

Source: Cagrilintide review (Cardiology in Review 2023, PMID 36883831); half-life ≈ 7–8 days

What people report

Reported median
0.5 mg / week
Who we read
229 in forum discussions · 49 on YouTube
Most taken with
Retatrutide · 110 people
Ever at the phase-3 dose
22 of 165 who name a dose

Counts of what people wrote about their own use: not a recommendation, and the two crowds are never added together. Read the full file.

Frequently asked

How long does Cagrilintide stay in your system?

With a half-life of ≈ 7–8 days, roughly 97% of a single Cagrilintide dose is cleared after five half-lives — about 37.5 days. Repeated dosing accumulates and takes correspondingly longer to clear.

What does a ≈ 7–8 days half-life mean in practice?

Every 7–8 days, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.

Where does this Cagrilintide half-life number come from?

Cagrilintide review (Cardiology in Review 2023, PMID 36883831); half-life ≈ 7–8 days. We cite a primary source for every half-life we publish and version every change.

Related: Cagrilintide reconstitution calculator · Cagrilintide dose charts

Watch: Why do people take cagrilintide so differently from the trials?

Two separate crowds, 49 people on YouTube and 229 in forum discussions, describe using cagrilintide very differently from the way the trials tested it. From our official channel — education only, never a dosing recommendation. Watch on YouTube ↗

Discussions

From the ZyraTrack community · on Cagrilintide

All Cagrilintide discussions →

Community posts are personal reports, not advice. Read the rules before posting.

Related half-lives

Other GLP-1 & incretin agonists — how long each stays active:

Compare all 26 half-lives →

Guides mentioning Cagrilintide

See your own estimated levels

The Zyra Track app plots this curve from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.

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