From Sema to Reta??

I came off 0.75 mg Sema and began Reta at 1 mg per week with no overlap. After two weeks I went up to 2 mg because I wasn't noticing much, and plan to try 3 mg after another four weeks.

I took my usual 1 mg Sema on Sunday and added 0.5 mg Reta mid-week. I raised the Reta very gradually without bumping both in one week and now sit at 1.5 mg Sema plus 8 mg Reta.

I'd begin with 2 mg of Reta.

1 mg of Sema helped me drop 65-70 lbs when it first appeared as a research item. With Reta I began at 1.5 mg, then moved to 2.2, 3, and 4 mg before reaching 8 mg. Starting somewhere between 2 and 4 mg seems reasonable.

I would begin at 1 mg daily and split the shots as needed to build exposure without going too high at once. When I bridged from Tirz I used 7 mg across six shots in week one and 36 mg across fifteen shots in the first month with no bad reactions.

I went 1 mg week one, 2 mg week two, then 3 mg week three on Reta. That last step left me feeling like I had a head cold. The first two weeks did almost nothing for me, but at 3 mg I can eat a couple of 8 oz tuna-and-egg meals and feel satisfied for the day.

I switched from 2 mg Sema straight to 3 mg Reta after stalling. In the first two weeks I dropped 11 lb. Now on week three of the 3 mg dose I notice almost no side effects compared with Sema. Reta just makes my brain register fullness while Sema used to give me an upset stomach. I also feel more irritable with people. Planning to move to 4 mg on week four.

2 mg of Reta looks like it could be the right place to start.

I was on 2.4 mg of the branded Sema before switching and restarted Reta at low doses. Looking back I probably should have begun around 4 mg, but I agree 2 mg is a sensible starting point.