CommunityStacking & Switching

3 Peptide stack

19 replies9 peopleMar 6, 2026☆ Follow
Summary

User experiences stacking Retatrutide with BPC-157 and Tesamorelin including dosing timing and side effects

Users report combining these peptides for fat loss and recovery with varied schedules. Retatrutide is often started low and titrated while monitoring appetite and sleep changes. Tesamorelin is frequently taken at night to align with natural GH pulses though some prefer morning for convenience. BPC-157 is commonly dosed daily at 500 mcg split or once for tendon issues with minimal sides noted across the stack.

What this discussion establishesWhere people disagree

Whether Tesamorelin should be taken every day or on a 5-on-2-off schedule and optimal injection timing for sleep quality

Still open

Long-term effects of continuous daily use and ideal total cycle length for the full stack

Nothing here is advice.

19 replies · 9 people
GreyPebble34archiveopening postMar 6

Wanted to check if anyone has tried Reta along with BPC 157 and Tesamorelin together. This is my first run with peptides and I am four weeks into 2 mg of Reta. Appetite suppression insomnia and constipation hit hard the first two weeks but those have eased off and I feel better with more food noise and improved sleep so I plan to move up to 3 mg next week. I added BPC 157 after seeing recovery info and have been looking into Tesamorelin for visceral belly fat loss. Anyone run all three and what doses worked or any extra sides to watch for. 46 years old started at 230 lbs now at 213 lbs.

ClearBeacon24archiveMar 6
↳ replying to @GreyPebble34 (opening post)

I have used them and plenty of others have too. Tesa works best at night right before bed to match natural growth hormone release.

SlowThistle12archiveMar 6
↳ replying to @GreyPebble34 (opening post)

Not the exact three but I began with half a milligram of RT three weeks back and added one point five of Tesa half of AOD and one point two five of Glow. Took two weeks to reach the AOD and Tesa levels. Only minor sides so far a small bump and itch from Tesa which seems normal.

ClearBeacon24archiveMar 6
↳ replying to @SlowThistle12

Agreed the itching usually fades after a couple months. Are you running AOD fasted in the morning?

SlowThistle12archiveMar 6
↳ replying to @ClearBeacon24

Yes I pin everything in the morning on their own schedule before eating anything.

ClearBeacon24archiveMar 7
↳ replying to @SlowThistle12

Looks like you have looked into these quite a bit.

BlueBeacon12archiveMar 7
↳ replying to @GreyPebble34 (opening post)

Running those three plus Ipamorelin now started the stack about a week ago. Also on 3 mg Reta but splitting the shots. Tesa at 2 mg daily either that or the Ipamorelin made me wake up too often when pinned before bed though I know most people sleep better on them. Still testing different times for both. BPC at 500 mcg twice daily once after training and again before bed injected near the elbow for tendonitis which already feels a bit better after one week plan to keep going another two or three weeks. No real sides from any of them some allodynia from higher Reta earlier and brief itch from Ipamorelin after the shot.

SteadyAnchor73archiveMar 7
↳ replying to @BlueBeacon12

Pretty sure you meant 500 mcg of BPC-157 not 500 mg right?

ClearBeacon24archiveMar 7
↳ replying to @SteadyAnchor73

lightbox related text that appears to be a site error message

GreyPebble34archiveMar 7
↳ replying to @BlueBeacon12

Do you run Tesa and BPC every single day without breaks or more like five days on two off?

WryQuill58archiveMar 7
↳ replying to @GreyPebble34

I follow a 5 on 2 off for the whole stack with Tesa 1.5 mg at night GHK-cu 1.5 mg in the morning BPC 1 mg morning TB500 three times a week at 500 mcg morning NAD+ 2 mg morning Selank 500 mcg morning Semax 500 mcg morning and Reta 1.5 mg once a week morning. Really enjoying the stack. Planning to come off Tesa after this next week for a 90 day run.

BlueBeacon12archiveMar 7
↳ replying to @GreyPebble34

I take both every day. Think a lot of the 5 on 2 off advice started because clinics were closed on weekends and to limit water retention from GH peptides. No strong reason to skip BPC daily and only if worried about water retention with Tesa but I am not concerned about that after one week anyway.

PlainAnchor67archiveMar 7

On HGH BPC TB500 Test and just restarted Reta. Went up too fast the first time so sticking to the recent study protocol now. Still do not feel much at lower doses like before. Have you done bloodwork yet might be helping in ways you cannot see. HGH has helped sleep a lot by far my favorite. Test is good but sleep was poor for years and better sleep means better recovery. Nothing noticeable yet from BPC or TB might try twice daily for HGH BPC and TB. Currently half mg each of BPC and TB 2 IU growth and 2 mg Reta.

SlowThistle12archiveMar 7
↳ replying to @ClearBeacon24

Yes many suggest night for Tesa but taking everything together in the morning is easier so I do not skip it.

WryQuill58archiveMar 9
↳ replying to @WarmHarbour52

Laughing 25 mg big difference thanks for catching that.

WarmHarbour52archiveMar 9
↳ replying to @WryQuill58

No problem just wanted to confirm you were getting a proper dose.

WarmSparrow60archiveMar 9

Tirz 15 mg every seven days Tesamorelin 2 mg morning fasted on 5/2 schedule BPC/TB4 3 mg daily 5-Amino-1mq 7 mg morning fasted daily GHK-cu 5 mg daily. Dropped AOD9604 and SS31 from previous stack and Sermorelin since Tesa worked better. Adding Mots-c next month after finishing the Tesamorelin cycle.

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.