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NY Post article today on peptides

12 replies9 peopleMay 10, 2026☆ Follow
Summary

Do peptide nasal sprays work compared to injections?

Forum users share mixed personal results with intranasal peptides versus subcutaneous injections. Some report zero effects from nasal use even at high doses with the same product that worked when injected, while others say certain peptides felt stronger or preferable nasally. Molecule size in Daltons is noted as a key factor for bioavailability, and one post flags the source article as paid advertising rather than news.

What this discussion establishesWhere people disagree

Whether intranasal administration works at all for most peptides, with some users finding it completely ineffective and others preferring it over injection.

Still open

Which peptides reliably work nasally and at what doses or formulations.

Nothing here is advice.

12 replies · 9 people
PatientPebble33archiveopening postMay 10

The piece centers on nasal sprays mostly, which I find intriguing anyway. I thought they weren't as effective as shots, though.

PlainAlder11archiveMay 10

Haven't checked the article myself, yet those nasal sprays enter the bloodstream quickly. Many cold remedies come as sprays or swabs for the nose.

CopperPebble12archiveMay 10

Dismissing nasal use altogether doesn't seem right to me, given how many peptides gain an advantage over swallowing them, and some that impact the brain could actually be more appropriate for it.

BlueTimber78archiveMay 10
↳ replying to @PatientPebble33 (opening post)

A lot of those SQ peptides seem workable when tried through the nose or under the tongue. You have to check the molecular weight listed in daltons. Over a thousand usually won't absorb properly. Tinier molecules usually have better uptake.

RustMarble22archiveMay 10

I want to point out this is sponsored content they accepted money for and not a regular story in the paper.

PatientPebble33archiveMay 10
↳ replying to @RustMarble22

Haha yeah the outlets covering events look like they're struggling with cash these days and that probably explains why they're acting frantic.

PatientPebble33archiveMay 10
↳ replying to @PlainAlder11

For a while now I've wanted to give that sleep peptide in spray form a shot through the nose so my rest improves.

RustPebble43archiveMay 10

My attempts revealed that peptides have no effect when taken through the nose. I've tried this many times over. Some peptides give strong visible results if shot in but nothing at all when done nasally. The same lot and even container was used sometimes so the peptides aren't the problem. Different techniques and amounts were explored yet nasal use failed every time. I went through almost a whole bottle of one nasally and got no reaction whatsoever. That same amount injected would have kept me in a state for ages. A small dose from the container worked fine when injected. Other peptides showed the same zero nasal results.

ClearLantern81archiveMay 10

Personally the nasal versions of Epitalon DSIP Selank and Semax worked out nicer than shots did.

PatientPebble33archiveMay 10

The two comments right before this one leave me unfazed.

QuietSignal61archiveMay 10
↳ replying to @PatientPebble33

SubQ injections are all I've done with it, but DSIP really appeals to me. My first dose was six hundred micrograms. I take it right before going to sleep.

QuietSignal61archiveMay 10
↳ replying to @RustPebble43

That piece of information caught my attention. Did you dissolve those with saltwater for nose sprays instead? How does the hormone affect your system? Are your shots given under the skin? Do you deal with turbo-autism too, and has this changed anything?

CopperAlder51archiveMay 10
↳ replying to @BlueTimber78

Yeah I see it the same way. Most of them end up doing nothing so any cash spent ends up lost for no reason.

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