CommunityFood & Appetite

Post-Mounjaro cut: Reta + Tesa + recovery peptides, looking for input

4 replies3 peopleFeb 1, 2026☆ Follow
Summary

Is a Retatrutide, Tesamorelin, Ipamorelin and BPC/TB/GHK blend stack suitable after Mounjaro for appetite control, fat loss and recovery?

The original poster describes rebound after stopping Mounjaro and proposes the new stack to manage hunger, continue cutting, preserve muscle and address skin and knee issues. One reply notes weaker appetite suppression on retatrutide compared with tirzepatide. The poster replies that glucose control mattered more than appetite for them previously. Another reply asks for regain details, DEXA data and dosing history while noting retatrutide may need higher doses for equivalent control.

What this discussion establishesWhere people disagree

Whether retatrutide provides comparable appetite control to tirzepatide; one user flags weaker effect while the original poster attributes prior success more to glucose control

Still open

Exact weight regained that is fat versus water/glycogen, current visceral-fat level, and whether retatrutide dose will need to be raised for sufficient food-noise reduction

Nothing here is advice.

4 replies · 3 people
PlainCompass18archiveopening postFeb 1

After dropping quite a bit of body mass on that medication, moving from one hundred five kilos down to seventy nine, I eased off it in stages. Yet after spending a month abroad eating heavily, the hunger signals and constant thoughts about food returned sharply, and the numbers on the scale started rising once more. So now I'm planning to bring back a similar type of compound, but a different one this time, mainly to keep those urges in check and shed some fat again.

My current aims are getting meals under control, trimming body fat while holding onto muscle, speeding up how I recover, dealing with some sagging around the midsection, and looking after an older knee issue involving cartilage from a prior ligament tear. My routine includes four resistance sessions weekly plus time in the pool and on the court for extra movement and heart work.

The mix I'm eyeing includes the new compound to handle daily intake and those urges, one aimed at internal fat plus skin support through growth pathways, another for better rest and healing via regular growth pulses, and a combination of several for local tissue fixes, knee upkeep, collagen help, and general bounce back. The first one mainly tackles consumption and food thoughts while the rest focus on healing, appearance, and staying capable during the reduction phase. I'm not looking to push anything extreme or combine heavy hormones, just aiming for something balanced overall.

From how the body works, does grouping them like this add up? Is there anything you'd drop, set aside for now, or rethink during reduction with this compound? Would like to hear from anyone who's tried comparable setups or knows the interactions.

QuietFenwick11archiveFeb 1

I've heard from several who switched away from tirzepatide that they end up dealing with weaker hunger management once on retatrutide. That part ends up mattering more or less depending on the individual.

PlainCompass18archiveFeb 1
↳ replying to @QuietFenwick11

I went through a similar thing with that one too. Managing my blood sugar levels seemed to help me out more.

LevelThistle44archiveFeb 2
↳ replying to @PlainCompass18 (opening post)

You dropped a bunch of weight using one medication but now seem interested in switching over to another compound. How many pounds came back on after stopping, and where exactly are you aiming to land? Did you get a body composition scan to check your fat versus muscle breakdown? How many weeks has it been since the final injection, and what schedule were you following so the remaining levels can be estimated? Among the main three options the newest one requires higher amounts to quiet hunger signals effectively even though it works once you reach that threshold. I moved from a combined top amount on the first drug to a larger total on the second just to keep the same control without adding back the prior medication. The added receptor activity is believed to spare muscle while raising daily burn which lines up with extra goals you mentioned. It shines during a deficit phase but the older option works fine if that extra receptor benefit is not needed. A scan would also show the internal fat amount which I expect will drop below average ranges ahead of my final scale number though I had considered another peptide if that did not happen. For sleep I currently use a mineral supplement yet I prefer to avoid relying on anything so I am trying to improve naturally. Separate vials make more sense to me than pre-mixed ones since I only want certain items at a time. I am finishing week four of an eight-week run with a healing peptide dosed at half a milligram morning and night for shoulder and elbow issues but I do not intend to continue it indefinitely until more is known about blood vessel growth effects. The copper peptide might stay in rotation longer once I reach that stage. Avoiding a fixed combination that forces extra substances was the main reason I went this route. Nothing seems problematic yet it looks like you moved from one item straight into planning seven at once. Once the gap between present numbers and targets is clearer the schedule for adding things becomes simpler to figure. Right now I am pushing a hard deficit with the newest compound plus tracking tools and I still have over a quarter of the way left to my checkpoint so my view might shift if the remaining distance were much shorter.

PlainCompass18archiveFeb 2
↳ replying to @LevelThistle44

I dropped from 105 kilograms to a low around 78 on that medication before quitting, then climbed back to 86 over the past several months mostly from daily life rather than slipping. End-of-year events, celebrations, and a long trip to Japan with lots of food played the biggest part. Most of the increase seems like stored carbs, fluid, and a little fat instead of a total reversal. Started at 32 percent body fat and now sit near 19 to 21. My lightest point was probably 17 to 18, far from contest condition. The aim is under 15, ideally 12 to 14, while bringing back muscle size and firming skin after the extended strict phase. The target weight shifts but will likely land between 78 and 82 depending on how the recomposition unfolds. I care about body makeup, not the number on the scale. No scan yet, though I know it offers clearer numbers, but repeated checks show fat tissue fell from about 32 to 33 kilograms down to roughly 15, with only 1.5 to 2 kilograms of lean tissue lost across the whole stretch. Given the pace and length of the diet, that feels like a reasonable exchange.

Use of the medication began April 22 2024 at 2.5 milligrams for roughly four weeks, then five for the longest stretch over several months, 7.5 for a shorter stretch, and 10 for three weeks. Total time came to about nine months, with the final dose several weeks back. This means some prior exposure without long highest-level use.

Switching to the newer option now because while it curbs hunger less per milligram, I am not trying to match the earlier appetite level. The plan is to cut again toward under 15 percent, protect muscle after the long diet, gain some metabolic lift from the other receptor instead of increasing the first medication further, and skip restarting the original which flattened everything out. It will probably take a higher overall amount to reach similar hunger management, and that works fine as long as intake stays controlled without going to zero.

The combination is not for experimenting. It is about gathering things after a tough diet stretch, with the new medication as the main cutting agent and any growth-hormone support kept for recovery and fullness rather than extra fat loss. I stay careful with ongoing repair compounds because of the blood-vessel growth issues. Nothing here is meant to last. If still sitting at 28 to 30 percent body fat the approach would stay much simpler and stricter. This is a follow-up cut plus recomp, not a crash. Thanks for the feedback, mostly just checking the overall direction and amounts without overcomplicating.

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