Tirzepatide Possibilities??????

With a workable diet and exercise plan you could drop quite a bit. Similar situation here, 41M, 6'4", started around 330. Been increasing tirz for about six weeks, eating better and doing light workouts to avoid overloading myself. Already down 20 pounds. Results will differ for everyone.

Trial data shows average losses at different time points. At 370 pounds and wanting substantial reduction, retatrutide might be worth considering. A steady one percent per week can be sustainable for long stretches; I've kept that pace for nearly six months. Early weeks usually see bigger drops from water. No need for heavy restriction diets. Focus on protein while still getting carbs and fats, and keep life enjoyable where possible.

Started tirzepatide in December 2024 at 335 pounds (6'4") and reached 244 by December 2025, a 91-pound drop or 27 percent. Your starting weight is higher, so scaling that percentage suggests roughly 100 pounds in a year is possible. Still, I agree with the suggestion to look at retatrutide if available; I would have chosen it over tirzepatide.

Tirz reduces the mental effort around food so better choices come easier. I settled on a few repeatable meals: turkey meatballs with zoodles and peppers plus premade marinara, air-fried chicken breasts with a spinach-strawberry salad and light dressing, and rotating Taylor Farms kits or baguettes. Having four solid options makes daily decisions simple and keeps things sustainable.

68-year-old female, started GLP-1s June 2025 at 393 pounds. Now at 323 after one year, mostly on tirzepatide, with no calorie tracking or added exercise. That's 70 pounds or 17.8 percent despite hormone issues, AFib, gout, CKD, and other conditions. Progress was far from steady. For a man without those complications, 100 pounds in a year seems reasonable.

If charts are the topic, mine shows tirz for the first month then a switch to reta. Linear regression puts average loss at 0.35 pounds per day.

The program you'll actually do is the best one. So far I've managed only occasional walks, around 5,000 steps even indoors. Bought a VR headset that mostly sits unused. Not a gym person and no space for equipment anyway. Considered a wall-mounted system because I like gadgets, but procrastination wins. Just one more peptide to consider.

6'4", 54-year-old male, started at 350, now 220 with a goal of 190. Began tirz July 2024, switched to reta after two months, reached 225 in about a year with no diet or exercise changes. Appetite control faded after roughly a year, so added another compound and have held 220-225 since. Current doses are 12 mg reta weekly and 2.25 mg of the other split.

You've seen the stories; it has to be experienced. Started at 330, down to 270 after a year without workouts. Daily tasks provide enough activity. It really teaches portion control.

Like most here, diet isn't a big concern; I eat what I can manage. Average responders should see 15-30 percent body-weight loss. Prioritize 8,000 steps daily over lifting while in a deficit, though lifting is fine if you enjoy it. It comes second to movement for now.

Younger at 34 and taller at 6'4", started at 325 and added tirz around 260 when progress stalled. Reached 191 yesterday after roughly two years total.

Good luck. I used GLP-1s only after dropping from 145 kg to 75 kg on my own. They help keep weight off far better than past attempts, where regain was common. Staying on them long-term makes maintenance realistic, unlike even surgery in some cases. Individual responses vary widely: a small group loses little, others drop a lot on low doses, and some face side effects. You have to start and titrate to see where you land.

The stories are motivating. My main worry is the reported difference in appetite suppression between tirzepatide and reta. I've heard reta's effect is weaker. Is that accurate?

Cut salt, oil, and sugar. Skip processed junk. Aim for 150-200 g protein daily and track only that. Fast 12-14 hours, working toward 16. Gym isn't an issue, so do four hours of weights weekly split upper and lower. Build to 10k steps most days. Combine all that with tirzepatide and health should improve noticeably in months.

No direct comparison since I've only used reta. At low doses food noise vanished quickly. Down 30 pounds in three months on 2-2.5 mg every few days. Avoiding former favorites like certain candy bars takes almost no effort. Kept existing resistance training; workouts feel better, likely from the weight loss itself. Because reta loss includes fat, muscle, and bone, protecting muscle through lifting matters. Best of luck.

The most sustainable diet adds foods rather than removes them: more protein or produce instead of chips. Track within a calorie target but repeat meals you enjoy, especially for office days. Added low-intensity walking on lunch breaks to raise expenditure without increasing hunger. Goal is overall health, not just scale weight. Started at 43 percent body fat in late March and have seen about 20 pounds lost so far. Monthly progress continues.

On tirz I averaged about two pounds weekly. Aimed for normal BMI rather than an arbitrary number. Retatrutide may raise heart rate, so monitor if choosing it, though trials showed higher total percentage loss. Tirz worked well for me, around 25 percent in seven months.

Older and started heavier than you, yet tirz has been excellent. 6'2", 55, began at 386 in early May on low dose, now up to next level, down 26 pounds in five weeks. No workouts, desk job. Diet shifted easily; cravings for fried foods disappeared and no junk at home. Meals are mostly salads, raw vegetables, certain soups, fruit smoothies, and minimal meat. Added B12, magnesium, collagen, and casein for support.

Get 4-6k steps at work with little strength training. Dropped from 237 to 200 in about two months on tirz with almost no other changes, now maintaining on 7.5-12 mg as needed for food noise. Lifestyle adjustments can produce even larger losses depending on tolerance. Watch speed of loss to avoid issues from rapid change or malnutrition; a multivitamin helps.

Everyone responds differently, so don't set limits based on others. Started at 445, 6'1", 61 years old, now 210 and still dropping. Made lifestyle and intake changes. Sequence was sema, then tirz, then reta.

Not sure what the low starting dose will do, but once at 5 or 7.5 mg most people find avoiding 60 pounds in four months would require deliberate effort.