Reta causing low or no sex drive?

I've been dealing with exactly this for roughly the past year and a half. Desire has been completely gone. Before starting Tirz I was always up for things, but about four months in after dropping around twenty pounds the interest disappeared. I have hardly been intimate with my wife for the last sixteen months or so. She has been very understanding but it has been frustrating. I looked into it and while there is some mention that it can happen it seems uncommon. It appears tied to the same reward system that reduces food cravings. Switching to reta did not change anything. I wondered if I was just stuck until I read about possible interactions with antidepressants and GLP-1s. I cut my dose of that medication in half and two weeks later things are not back to normal but I am noticing more interest again. It might be wishful thinking but it feels like a positive shift worth noting.

Wow, that description fits me perfectly. I have been trying to explain how I have been feeling and emotional flatness captures it exactly. At my yearly checkup I asked my doctor if it was normal at my age not to feel excited anymore and she said it is just part of getting older. She also does not know I am taking reta. This lines up so well and it is good to know I am not the only one. Thanks a lot.

I had not considered how it might interact with the bupropion I take every day at the lowest dose. I will try taking it every other day and see if that makes a difference. Thanks!

I do workouts five or six times a week, a bootcamp style mix of strength and cardio days. I am female and will turn 42 next month. As for eating well, not really. Appetite is low so I try to get some protein in but I am nowhere near 50 g a day and I know that is not good.

Same here with bupropion. I dropped from 300 to 150 and it has definitely helped.

This is so helpful. I also had a full panel done and my SHBG is 92. I did not think much of it at the time because the app showed it within range though on the higher side. I am also considering lowering my dose to see if feelings and libido return. Thanks so much.

Glad it helped. What worked for me was going back to maintenance calories for a couple of weeks, keeping carbs reasonably high or even a bit higher, and making sure to include healthy fats for hormone support. That should get things moving again so you can continue your progress. Good luck.