Has anyone tried 4 agonists together — GLP1, GIP, Glucagon, AND Amylin

I looked into this same idea for several hours yesterday and settled on pairing Reta only with Cagri or Tirz only with AOD. Pairing Tirz with Cagri seems likely to slow digestion too much and cause stomach problems for me. I will stick with Tirz plus AOD for now and add a little Reta only if progress stops. Once I get closer to my target I expect to move to Reta and Cagri for ongoing appetite control without raising heart rate or stomach trouble while Tirz is still working well.

That makes sense. Three together might be overkill. I could follow the same approach with very small amounts and just try Reta plus Cagri.

I take 1.5 mg of Cagri each week with Reta and have not seen any real extra effect.

Since February I have been using Tirz, Reta and Cagri together. Mondays are 7 mg Reta plus 0.8 mg Cagri and Fridays are 7 mg Tirz plus 0.8 mg Cagri. Weight loss picked up after the Cagri was added.

I already have the pieces but have only just begun adding Reta to my Tirz. Cagri would come after I settle on the current pair.

My guess is ending up in the ER with sudden constipation and dehydration.

I have been on 15 mg Tirz and 6 mg Reta per week for about a year and added 0.5 mg Cagri weekly. Any higher dose of the amylin part makes me feel sick. Note that Cagri also acts on calcitonin receptors so that is five pathways at once.

There is a whole section on eloralintide and many posts about that exact stack. Anyone combining Cagri or Eloralintide with Reta is already using all four pathways, and early reports have been positive.

Last Tuesday I began adding 1 mg of eloralintide to my existing 8 mg Tirz and 6 mg Reta stack in hopes of moving past a five-week plateau.

Right now I am on 15 mg Tirz every six days, 6 mg Reta every six days and 3 mg Cagri every six days on a two-day stagger. No major stomach trouble; I can still eat a half chicken with only mild discomfort. Reta and Cagri do not seem to affect me as strongly as they do others. I started the three-way stack five months ago to move past a stall after already losing 41 lb on 10 mg Tirz. The triple stack began at lower doses and I have since lost another 17 lb for a total of 60 lb, now at 26 percent body weight lost. I switched because raising Tirz alone caused painful skin sensitivity and worse tinnitus that never fully went away.

I have not tried eloralintide yet but others in a group I follow prefer it over Cagri. I plan to get some and will probably stop Reta at the same time to give the GLP receptors a rest. Reports suggest 2.5 to 3 mg gives clean hunger control without mood flattening, faster heart rate or stomach upset.

I am using 4 mg Tirz, 2 mg Reta and 1 mg Cagri while trying to drop the last 10 lb. No issues so far but loss has also stopped and appetite suppression is only mild.

I pin 4 mg Reta and 1 mg Cagri together on Thursday mornings. After lowering semaglutide and raising Reta, adding the Cagri finally gave the hunger control I needed to finish losing the last 5 kg. I am now at 14-15 percent body fat and would like to go a bit lower but will need to add resistance training.