Hey guys, I started reta back in June at 2 mg and have worked up to 5.5 mg. My weight went from 121.5 kg down to 98 kg. I used to be athletic but put on a lot after corona, marriage and an injury. My usual walking-around weight was around 90 kg and I had repeated failures trying to get back there with lots of relapses. Now I'm doing better and want to reach 85 kg, but I'm reluctant to raise the dose much more. Reta doesn't feel as strong as before, though I can still manage my appetite and eat around 2000 calories while training five days a week with BJJ and weights. I'm active, taking supplements and eating well, but I'm worried about going higher because I don't want to become less sensitive to the drug.
Dose and bounce back anxiety
Should I raise my reta dose to keep losing weight or risk losing sensitivity to the drug
The original poster has lost 23 kg on reta but is hesitant to increase beyond 5.5 mg because the medication feels weaker and they fear reduced future responsiveness. Other users explain that no solid evidence shows tolerance to appetite or weight-loss effects while staying on the drug; the slowdown occurs because more of the drug's action now goes toward weight maintenance as energy expenditure drops and hunger rises. Micro-dosing for maintenance is viewed as preferable to stopping entirely.
What this discussion establishes- No proven tolerance develops to reta's effects if dosing continues without breaks
- Weight loss naturally slows once a large amount has already been lost
- Diet and exercise alone had previously failed for the poster over many years
- Small maintenance doses are considered better than going cold turkey
- Some users space injections every two weeks once at goal
Whether the poster should increase the current dose to reach 85 kg
Nothing here is advice.
I tried a new brand last month after my usual one ran out. The effects hit slower than expected and didn't last as long either. The overall experience felt weaker and less consistent compared to what I was used to before.
There's no proof these medications stop curbing hunger or aiding fat reduction during steady use, so there's little basis for worrying about raising amounts later. Pausing then resuming might trigger that issue, though only hints from rodent work and scattered online reports suggest it, without solid confirmation. What feels like weaker results now likely stems from already shedding quite a bit—twenty three kilograms—so the main task shifts to blocking regain instead of pushing further drops. Body changes with lower weight also mean fewer calories burned daily and stronger hunger signals. Any fixed level eventually brings progress to a halt. It appears the belief still lingers that weight can be managed through food choices and movement alone, yet from the details shared that route produced no lasting success over years while this approach has delivered solid changes. Reaching the goal seems blocked only by not raising the level. Managing body weight properly therefore requires staying with it and going higher to arrive at a lighter point. Age or weight related conditions aside, continued use of this class actually supports overall health and cuts risks for several serious issues such as blood sugar problems, heart trouble, and tumors. The wish to quit comes less from medical grounds and more from the usual outdated view that excess weight boils down to discipline plus lifestyle tweaks. That old method fails for most people over time, while these options succeed for the majority and hold results steady for years or indefinitely with ongoing treatment.
Even a tiny weekly amount seems preferable to stopping completely during upkeep periods. After abruptly halting another similar medication for several weeks, I realized any small ongoing dose beats total absence. A few users space their shots out to every fourteen days and find it works fine for them. Studies on this approach back that up.
I've wondered what others think about eventually reducing or quitting these meds altogether. Plenty assume lifelong use is required, yet suppose someone hopes to avoid that. I began at a high weight, dropped substantially over time, then held steady for well over a year by sticking to better habits without further loss. Now that I'm using this compound, the question of how to come off it later keeps coming up. My own plan was always a short cycle of several months followed by relying on adjusted eating alone, though I expect it won't be simple. Research on stopping after initial success shows many regain despite keeping up diet and movement changes. One trial split participants after a period on the drug plus lifestyle tweaks, with the group switched to placebo seeing notable rebound. Another looked at what happens when doses are lowered or paused after reaching a stable point around a year in. Some data also point to moderate amounts working well for extra benefits like cholesterol improvement alongside the main effects, which makes me think about adjusting upward if needed to sustain progress.
Appreciate the detailed reply. Honestly I reached the same weight drop on my own before but it took twice as long and came back quickly. Still I did put on some muscle so it wasn't a total waste. I'm 28 now. Weight loss isn't stalled at the moment but side effects got worse once I went past 4 mg, like heart palpitations and trouble sleeping, so I'm nervous about going higher. Maintenance has been on my mind a lot lately. You see everything from claims that holding the new weight for two years lets your body adjust to the idea that you need to stay on this for life. Science-wise I can't sort it out, but from what I've seen it makes sense to keep a lower amount going for some time after reaching the target. I wasn't heavy before, only started gaining from 2021 onward.
A lot of people move over to another similar medication for the upkeep phase. Or combine it with others. A couple of those options don't push heart rate up. Splitting the dose is one more way to handle the unwanted effects. I like splitting because it also helps with hunger coming back. Some ideas for dealing with sleep trouble include having a low-fat complex carb about half an hour before bed and sorting out any reflux. There are also mentions of certain minerals and amino acids that people take to support the heart while using this. The same ones come up for sleep too. Extended-release melatonin stands out for waking too early. Once you figure out the right mix the sleep problems often settle down anyway. At this stage taking the full amount in one go doesn't bother my sleep any more than spreading it out. I haven't felt any change in heart rate either.
There's this supplement I take that studies show helps reduce fat around the stomach area. I swallow two capsules before heading out for morning cardio without having eaten first.
Cheers! Avoiding any calculations this early in the day.
I started out wondering how many weeks anyone remained at that four milligram level prior to stepping higher. I also wanted to know what amount came after. Plenty of people mention running into strong reactions once shots pass that mark. Splitting my own doses into smaller portions across two days each week made things easier to handle. Whenever the problems stayed rough I dropped back and then added two to three milligrams from the other option a few days afterward.
Thinking eight milligrams is suitable to finish off the remaining distance. If progress halts completely I could raise the amount. At present there is just a reduction in pace and that works fine for me. Training in Brazilian jiu-jitsu feels much better lately after dropping some mass. My pattern has been raising the dose half a milligram every couple weeks beginning at two. Perhaps dividing the shot would help. The problem now is lacking a specific target weight and instead aiming for a certain appearance. Hoping to reach that near eighty five kilograms.
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