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Has anyone hit their goal weight and tapered off retatrutide?

42 replies28 peopleJul 6, 2026β˜† Follow
Summary

What experiences have people had tapering off retatrutide after reaching goal weight versus staying on a maintenance dose?

Users who reached their targets report mixed approaches: some lower the dose gradually to a low weekly amount and space injections further apart while monitoring weight and appetite, others plan to remain on a reduced dose indefinitely for ongoing benefits. Several note that stopping often leads to weight regain and that restarting may require higher doses with diminished results. A few have successfully maintained for years by using brief low-dose periods only when needed. The thread shows ongoing debate about treating obesity as a chronic condition requiring long-term medication.

What this discussion establishesWhere people disagree

Whether retatrutide should be continued indefinitely like a chronic-disease medication or used only until goal weight is reached and then stopped

Still open

Long-term outcomes for those who fully discontinue versus those who stay on low-dose maintenance

Nothing here is advice.

42 replies Β· 28 people
BlueCinder18archiveopening postJul 6

I'm 168 cm, female, started at 70 kg aiming for 55 kg. I reached that in roughly six months by titrating slowly from 0.5 mg up to 4 mg. The physical change is clear, including dropping from a 27-inch to a 24-inch waist. I'm pausing now to reconsider my next steps and want to hear how others have handled moving from weight loss into maintenance or coming off the medication. Some mention cycling on and off, but I've also seen suggestions that stopping and restarting later means beginning at the lowest dose again.

BrightSparrow36archiveJul 6

Cycling doesn't fit with these medications. Both reta and tirz provide meaningful health benefits separate from the weight loss itself. The better approach is to lower the dose gradually and remain on something like 0.5 mg or another low amount on an ongoing basis.

QuietThistle43archiveJul 6

I'm roughly 15 pounds from a 100-pound total loss. I had already dropped to 5 mg but raised it back to 8 mg recently to finish off the last stubborn areas around my belly and back. Once I hit goal I intend to settle at 5 mg of tirz each week.

AmberBeacon78archiveJul 6

I'm still not fully comfortable with the idea of staying on these medications long term. When I reach my goal I'll ease the dose down, perhaps a bit past target, then stop and see how I handle things without it.

LevelThistle44archiveJul 6
↳ replying to @AmberBeacon78

On average people regain the weight, and when they restart the medication it tends not to work as effectively as before. It becomes a repeating cycle.

BrightSparrow36archiveJul 6

It surprises me how uncomfortable some people are with taking a medication that clearly improves their health, especially when so many other supplements and prescriptions are used routinely, sometimes with little or no benefit. For me this feels comparable to a multivitamin, except the positive effects are obvious. The cost is also less than some other supplements I take that don't do much.

PatientFenwick65archiveJul 6
↳ replying to @BrightSparrow36

That's a fair point. I take things like vitamin C because the body needs them daily. I'm using reta only to reach a specific goal and plan to stop once I get there. If there's a reason to keep taking it I'd be open to hearing it. I'm asking because I want to understand, not to argue.

BrightSparrow36archiveJul 6
↳ replying to @PatientFenwick65

Have you looked into the range of health benefits that come with reta?

CopperAlder51archiveJul 6

I've hit my final target and am now lowering the dose for maintenance. I was up to 12 mg and am currently at 6 mg. I'm trying to find the right level that holds my weight steady while keeping the other benefits that matter almost as much.

SharpWillow20archiveJul 6
↳ replying to @BrightSparrow36

I already take about ten supplements plus two prescription medications daily. One of those prescriptions might be stoppable now that my A1C is below the diabetes range thanks to reta. I'll stay on a GLP-1 but am considering switching from reta to tirz once I reach goal in about a month.

SharpWillow20archiveJul 6
↳ replying to @CopperAlder51

How quickly have you been lowering the dose? Are you noticing hunger coming back?

PatientFenwick65archiveJul 6

Oh, I didn't realize that. I was only using it to lose weight. That's really interesting! Not sure about sharing links here, but I came across an article that relates to what you're saying.

CopperAlder51archiveJul 6

Weight reduction occurred more rapidly than expected. Rather than decreasing monthly in the same manner I increased, the pounds continued to drop. I exceeded my target by eight pounds, leading me to reduce the amount every fourteen days. Strong hunger control persists, and Reta has consistently performed well for me. Two normal meals per day is my routine. I adjusted to six milligrams recently, so time will tell. Stopping there might be necessary, or reducing further to four could happen.

SteadyQuill55archiveJul 6

Imagine some magical being popping up before those treatments existed, like an idle make-believe sorcerer, and offering me lasting slimness. The requirements would involve an easy weekly shot done at home indefinitely, with the thinness vanishing if I ever quit, plus handing over a monthly fee forever. Accepting the deal would happen right away, since waiting through the whole pitch before shouting my agreement would be the toughest part.

NorthWillow72archiveJul 6
↳ replying to @SteadyQuill55

It was comical the way that avaricious fairy insisted upon substantial recurring costs and I agreed to participate anyway!!

LevelThistle44archiveJul 6

Suppose a person adjusts one element to hit a lasting target such as dropping pounds then halts the adjustment what follows for that target dropping pounds does not count as an endpoint for most people usual habits around food and movement seldom deliver big reductions and almost never hold them steady these substances appear to deliver those reductions and hold them steady without end from what shows up unless use ends if use ends the pounds come back and later rounds with the substances may deliver weaker results along with smaller gains from the same work keeping that work going stays tough across long stretches.

PatientBramble81archiveJul 6

I had prior experience with a similar compound before starting this one toward the end of last year. I reached a moderate dose and kept it steady for quite a while since it worked well enough and supported ongoing fat loss without needing an increase. That level suited me for around five months. Only lately did I test a higher amount just to check my tolerance. Turns out I react strongly to it. I ended up dropping more weight than intended, which is the truth even if it sounds unusual. Side effects showed up too. Beyond holding at what feels like the right balance for me, I have looked into ways to add back some body mass with an emphasis on muscle. Maybe combining these at reduced levels could help. Perhaps adding another option into the mix as well. It has been an interesting process overall.

RustKettle12archiveJul 6

I began taking reta during a fat loss phase and dropped thirty pounds across three months. That progress has reached its limit without harming my lifting results at the gym. I'll slowly reduce the amount to point two five milligrams each week from the one milligram level I'm on now, continuing that way for a few months before quitting altogether. With plenty kept in reserve I can resume later if needed.

IronKettle95archiveJul 6

Dealing with excess weight as a long-term issue, not focused on getting ripped or shedding a few kilos ahead of an event. I accept that this medication will be part of my routine indefinitely. It's normal for people to stay on treatments permanently when managing things like hypertension, high lipids, or sugar imbalances, but when it comes to body weight, they often assume the drug can stop after improvement. Diet alone could address those issues in theory, though everyone knows most people won't stick with it successfully. Being overweight qualifies as a chronic illness that calls for pharmaceutical help in the majority of cases. This has nothing to do with having no discipline or failing at self-restraint.

IronHarbour22archiveJul 6

People get put off mainly because it arrives via needle, stirring up all those unpleasant mental links from muscle boosters, athletic cheating, vein shots and the scary tales connected to them. But once you accept this amounts to nothing more than an administration technique, just like gulping oversized capsules containing a plant from another continent that claims to enlarge male anatomy by a couple inches, the key difference is this version actually succeeds.

PlainAlder11archiveJul 6
↳ replying to @CopperAlder51

I've gone beyond my target and mustn't drop any further pounds so it's time to begin reducing the dose. I'll continue using this long term as well. Planning to maintain my wife at nine milligrams temporarily.

SteadySparrow75archiveJul 6
↳ replying to @SteadyQuill55

Everything wrapped up nicely for us in the end with total contentment πŸ‘

ClearLantern70archiveJul 6

This thread gave me some useful info. Taking my current dose after dropping 45 pounds with about 50 still ahead. Haven't decided on any way to stop yet. Still I get in plenty of workouts these days. Moving feels simpler without the extra weight around. I actually enjoy hitting the gym more now. Planning to pick up ideas from everyone here. Staying on it long term works for me.

SlowLantern29archiveJul 6
↳ replying to @PlainAlder11

What a curious way of wording that idea. I wonder if she has mentioned her own perspective on the matter.

GreyHarbour88archiveJul 6

Study results plus online user stories point to fast weight comeback once treatment ends. The bigger issue comes with starting over, since the earlier strength fails to restore things properly.

GreenBeacon40archiveJul 6

After hitting my target weight, I'm now in my second week without the medication. It's been nice having my usual resting pulse rate again. The urges to eat haven't returned like they used to, and I'm paying closer attention to what goes on my plate. Probably because I put in a lot of effort studying how to keep the pounds off and remain active, those previous patterns just haven't crept in.

PatientFenwick65archiveJul 6
↳ replying to @LevelThistle44

It's tough keeping up the work long term, sure. Still, some kind of dedication has to happen one way or another. That means sticking with this medication indefinitely, or sticking with food choices and workouts forever, maybe both. There will be downsides if you quit, like you said. I began using it not aiming for a particular number on the scale. What matters to me is dropping enough body fat to feel satisfied when I check my reflection. I'm getting near that point now and have set up a scan to measure my starting composition at a time when my look feels right. This is just about the fat part though. I know I still need way more muscle mass before others would find my appearance appealing. With those results in hand and once more of my midsection shows through, the idea is to slowly stop the medication, ramp up weight work, and maybe check out hormone options to help kick things off. After half a year or so of steady work, I should be further into building muscle and closer to the physique I'm after. Then I'll have a full year of bloodwork without the medication and can do another scan. Should it turn out I need to resume it for losing fat again or keeping good test numbers, that's what I'll do.

LevelThistle44archiveJul 6
↳ replying to @PatientFenwick65

It's like weighing the work of using this medication against the constant grind of tracking intake and staying active for years ahead. I picked a target weight along with a desired physique. Aims either succeed or fail outright while objectives serve as loose ideals to chase. That physique objective lines up with a certain scale number based on the four scans I've completed recently with one more scheduled soon. I began hormone support early this year to hold onto muscle and manage low testosterone symptoms. I'm not deeply into your method just sharing how things turned out for me. I'd rather savor daily living than stick with strict habits to avoid needing these tools. Years back I shed a large amount through standard routines but regained most once those routines ended. These days I'm below that earlier low point and can go about things without food limits or mandatory activity to stop any comeback later on.

PlainAlder11archiveJul 6
↳ replying to @ClearLantern70

I'm not at my target weight yet, so there's no need to stress right now. She is aware of the situation and would like me to reduce the amount. I've got about seven or eight pounds left to drop, and I kept using nine milligrams on account of the fat under my skin in the abdominal area, plus I hoped to lower my body fat percentage, though that would involve crunches and similar exercises which I dislike. She had, and continues to have, a greater amount to shed compared to what I needed. I can't figure out why she gained that extra weight so suddenly.

LevelPebble75archiveJul 7

Roughly two years back my situation lined up with yours. At 168 cm my scale reading fell from 68 kg to 56. The peak amount I ever used reached just 2.5 mg of Reta. After landing at 56 kg I began stretching the time between my shots to every two weeks. After that I eased the amounts down bit by bit. These days, two years on, I run a three- or four-week stretch of 1 to 1.5 mg weekly about every eight weeks or when my body signals it, and the weight has stayed off.

LevelTimber64archiveJul 7
↳ replying to @PlainAlder11

Sounds like the choice belongs to her, doesn't it?

IronLantern24archiveJul 7

Right now I'm facing a tough choice. Today I hit the target weight I've been aiming for, but I'm not prepared to shift into keeping it steady yet. Over the past nineteen months I've dropped ninety pounds already, so pushing for a full hundred seems worth doing. Once that new stuff arrives I'll begin using it and can think about this again at that point.

SlowLantern29archiveJul 7
↳ replying to @PlainAlder11

Is she showing interest in what's happening? How does she feel about the whole thing? (I've tried guiding several people. Folks vary in how much they care. It catches me off guard since I'm really into this subject and always want to know more about it!)

BlueCinder18archiveJul 7
↳ replying to @LevelPebble75

It's really useful knowing someone else has experienced something like this. Reducing gradually appears to work well for staying consistent under supervision. I aim to begin cutting back on the amount this week aiming for a stable 2mg per week ongoing and then increasing intervals to three or four weeks when my body adapts. Did hunger and cravings for eating return in an obvious manner?

LevelPebble75archiveJul 7
↳ replying to @BlueCinder18

Sort of, though I see it as pretty standard for myself. Whenever things start feeling out of hand I spend several weeks cutting from 1.5 down to 1 mg until everything feels steady again πŸ˜…

BlueCinder18archiveJul 7
↳ replying to @IronLantern24

After reaching my target weight, pushing reta too high seems to make it tougher for the system to hold steady, based on what I've picked up. That's the main reason I'm thinking about cutting back on my amount. What results are you aiming for from the tesa and ipa combo?

LevelBramble14archiveJul 7

Evidence from research supports this beyond personal accounts. Starting and stopping doesn't help matters, and alternating between those options seems to raise comparable concerns based on user reports. I don't get why people resist seeing this for ongoing management of persistent issues like blood sugar problems or elevated pressure.

BlueTimber78archiveJul 7

I've reached my target and switched to keeping things level with a reduced amount every five days after the peak of twice as much on a three-day cycle. My weight hasn't shifted over the last three months.

SlowBramble67archiveJul 7

Over the next couple of months, I intend to discontinue Tirz. Weight loss continues even with the 2 mg upkeep level, and appetite stays absent on day six or seven. For nearly a month, I've maintained a daily fast between 10 at night and noon. Maybe I've grown accustomed to the hunger by now. The rest of the time, my meals provide adequate nourishment, though sugar is avoided and carbs plus fats remain minimal.

PlainAlder11archiveJul 7
↳ replying to @LevelTimber64

Yeah I'm going to continue with the shots but using less each time. My plan is to get through the remaining nine milligrams. She seems okay with it all. She understands everything that's happening. It was actually her suggestion to begin after we discussed the idea.

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