Cycling doesn't fit with these medications. Both reta and tirz provide meaningful health benefits separate from the weight loss itself. The better approach is to lower the dose gradually and remain on something like 0.5 mg or another low amount on an ongoing basis.
I'm 168 cm, female, started at 70 kg aiming for 55 kg. I reached that in roughly six months by titrating slowly from 0.5 mg up to 4 mg. The physical change is clear, including dropping from a 27-inch to a 24-inch waist. I'm pausing now to reconsider my next steps and want to hear how others have handled moving from weight loss into maintenance or coming off the medication. Some mention cycling on and off, but I've also seen suggestions that stopping and restarting later means beginning at the lowest dose again.