Genetic tests for weight issues

4 replies5 peopleMay 26, 2026☆ Follow

Summary

Can genetic testing identify causes of obesity when GLP-1 drugs fail to work well?

The original poster with low T, Hashimoto's and fatty liver reports only partial success with retatrutide and has a July referral for genetic testing, preferring to treat any root cause first. Replies indicate single-gene testing applies mainly to early-onset or extreme obesity, while typical adult cases involve many genes with no available gene therapies to treat. Emphasis is placed on using GLP drugs alongside calorie tracking rather than expecting medication alone to produce results.

What this discussion establishes

Genetic testing is mainly relevant for monogenic or early-onset obesity
No gene therapies currently exist for obesity
Multiple genes usually contribute to adult obesity so testing rarely changes treatment
GLP drugs require active calorie deficit to work effectively
User has July referral and wants to address any identified cause first

Still open

Whether the scheduled genetic testing will produce actionable findings for this individual's situation

Nothing here is advice.

4 replies · 5 people

KeenKettle50archiveopening postMay 26

Anyone here gone through genetic counseling from doctors for their struggles with weight? I deal with low testosterone, Hashimoto's thyroiditis, and fatty liver disease. Those two medications had zero effect on me. Only this newer one seems to assist in shedding pounds at a regular pace, though the results aren't as impressive compared to what people share online. My hormone doctors scheduled me for genetic tests in July. I've figured out a cheaper way to obtain that medication, yet I'd much rather identify the root issue and address it instead. What do others think?

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SlowSignal40archiveMay 26

↳ replying to @KeenKettle50 (opening post)

Bro, are you asking about why the GLP drugs are not working properly?

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WarmMeadow92archiveMay 26

↳ replying to @KeenKettle50 (opening post)

What exactly are we discussing as the root? Extra body weight? DNA checks might matter more when issues start young or get really severe and a single gene looks responsible. For regular adult weight gain heredity still matters but spreads across lots of genes so results won't shift any handling or steps taken. Besides nothing exists to fix it anyway. Treatments aimed at genes for this don't exist yet so identifying a genetic root wouldn't let you address it directly. Still I'm fully behind DNA checks and have done them for other health problems though even then they mainly guide how to handle related issues.

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GreenMeadow54archiveMay 26

I've seen cases where someone could overpower the appetite control from these meds just by deciding to eat more anyway. When taken properly they support picking smarter options that lead to real progress with weight. Counting on the medication alone to handle everything tends to bring weaker outcomes. Tracking daily intake helps identify the level that keeps weight steady then staying below it becomes simpler with the meds but the core rules stay the same.

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SharpAnchor92archiveMay 26

That catches my attention. I'd like to hear updates about the conditions your physicians are investigating, along with the outcomes from the DNA analysis and the strategy they come up with afterward.

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