Reta (+Cagri) stopped working

I know at least three people on 20 mg of reta right now, one of them female.

Getting up to twelve milligrams left me stuck with no further progress and feeling ill. Quite a high amount. In my situation I split that amount and combined it with another medication since reports indicate it handles appetite more effectively. Although I never tried the second one myself accounts from others showed the pairing outperformed the first substance by itself. On my own adding a different compound quickened how fast the pounds came off. It might also mean the batch I received was not effective. Being unsure of the total quantity I had checking a single container seemed worthwhile to me.

I wonder what my daily intake numbers look like these days. A couple folks mentioned hitting a plateau until they raised what they consumed and then progress picked back up. It seems the system knows more than we realize and when it senses a lack of fuel it pushes back somehow. This may not apply here but I have been thinking about whether mine are too restricted.

For hunger and food noise you could try 7 mg every 3.5 days. That keeps the same peaks as 12 mg weekly with no extra sides but raises the valleys and average level. I tried it and it helped a bit, then added 0.25 mg cagri and the noise disappeared completely.

Tesa raises the ghrelin hormone and that effect fades once the cycle ends.

Two things stand out. First, tesamorelin stimulates HGH which can raise appetite and cause fluid retention that might hide further scale movement. Stopping it should let any extra water drop in a week or two. Second, after losing a lot of weight like your 16 percent, energy expenditure falls because there is less tissue burning calories and metabolic adaptation sets in from the long deficit.

Reta at higher doses works differently, not exactly like food noise but it can affect heart rate. Cagri has been used up to 5 mg though it is not for everyone.

The explanations are helpful. I also have high tolerance to most medications like ibuprofen, tramadol, and nasal sprays. My doctor mentioned a possible gene variant or cortisol, but morning cortisol checks have been normal.

It could be the tesa interfering. You might be a high responder and it can increase hunger, insulin resistance, and blood sugar. The glucagon part of reta tells the liver to release glucose, so both could raise blood sugar while tesa adds resistance. GLP-1 signaling is sensitive to that context. Receptor desensitization is possible but since cagri also stopped working it points more to blood sugar. Options are to pause tesa, go low carb, or try lowering reta temporarily. Stress can worsen insulin resistance too, and a glucose meter might be useful to check.

Optional non-GLP peptides are a nice distraction during stalls. I just ordered a vial of PE-22-28 to try. As long as weight is not rising beyond possible water from tesa you could keep going and focus on body composition and bloodwork instead of the scale. You already seem to be maintaining muscle. Besides cagri, sema is another common stack with reta. Are you fasting around tesa doses? My own GH peptide use pushed me into intermittent fasting. Lower dosing or five days on two off might reduce water retention if you stay on tesa.

Higher doses may eventually be accepted for people who show low response and few sides, but not for those limited by sides. Studies so far on sema at 7.2 and 16 mg showed extra loss but more sides. The tirz higher-dose trial is still running. It would be useful to test higher doses specifically in the low-responder group, though that is unlikely soon. Anecdotal reports online are interesting but not solid data.

One obvious possibility not mentioned yet is that tesa raising GH could be adding muscle mass. You might still be losing fat while the scale stays flat from lean-mass gains. The other points raised earlier cover the rest.

A previous similar thread had a weight graph that stayed flat right after HGH-related drugs were added. If you have a record or graph it could show whether loss slowed gradually or stopped abruptly when tesa started, which would point to the cause.

At my age and IGF-1 score a ceiling around plus 100 seems a safe starting point. After more than 12 mg reta plus cagri I think visceral abdominal fat is now the main remaining issue. Tesa might help with that.

Water percentage is also up. I took my first tesa 1 mg plus ipa 100 mcg last night but I am not counting on miracles.

I am moving ahead with only tesa plus ipa, no CJC, no off days, titrating up to 2000/250 mcg until waist measurement drops. I am also wearing a CGM now.